Fusion Dynamics of Aqueous Glutamic Acid/Aminodecane/Ibuprofen Vesicles

Vesicles have been prepared at a constant molar ratio of L-glutamic acid/1-aminodecane/ibuprofen/H₂O. The fusion dynamics of the vesicles have been directly observed and followed by using optical microscopy and freeze fracture replication-electron microscopy technologies. With time increasing up to 25 minutes, the vesicles slowly fuse to form large stable vesicles. A membrane phase transition temperature is detected at 97°C.     

Two ZnII mononuclear coordination compounds with pyridinedicarboxylate and auxiliary N‐(pyridin‐4‐ylmethylidene)hydroxylamine ligands

Two new mononuclear coordination compounds, bis{4‐[(hydroxyimino)methyl]pyridinium} diaquabis(pyridine‐2,5‐dicarboxylato‐κ²N,O²)zincate(II), (C₆H₇N₂O)₂[Zn(C₇H₃NO₄)₂(H₂O)₂], (1), and (pyridine‐2,6‐dicarboxylato‐κ³O²,N,O⁶)bis[N‐(pyridin‐4‐ylmethylidene‐κN)hydroxylamine]zinc(II), [Zn(C₇H₃NO₄)(C₆H₆N₂O)₂], (2), have been synthesized and characterized by single‐crystal X‐ray diffractometry. The centrosymmetric Zn^II cation in (1) is octahedrally coordinated by two chelating pyridine‐2,5‐dicarboxylate ligands and by two water molecules in a distorted octahedral geometry. In (2), the Zn^II cation is coordinated by a tridentate pyridine‐2,6‐dicarboxylate dianion and by two N‐(pyridin‐4‐ylmethylidene)hydroxylamine molecules in a distorted C₂‐symmetric trigonal bipyramidal coordination geometry.     

The solvent effect in obtaining of acid–base multicomponent systems: thermal,structural and luminescence study

Journal of Thermal Analysis and Calorimetry - Acid–base multicomponent systems based on active pharmaceutical ingredients 2-chloro-5-nitrobenzoic acid (2Cl5NBH) and monoethanolamine were...     

Purification and structure elucidation of three naturally bioactive molecules from the new terrestrial Streptomyces sp. TN17 strain

Thirty litres of fermentation broth was extracted from the newly isolated Streptomyces sp. strain TN17 and various separation and purification steps led to the isolation of three pure bioactive compounds (1-3). Compound 1: cyclo (L-Leu-L-Arg), a diketopiperazine 'DKP' derivative; 2: di-(2-ethylhexyl) phthalate, a phthalate derivative; and 3: cyclo 1-[2-(cyclopentanecarbonyl-3-phenyl-propionyl]-pyrrolidine-2-carboxylic acid (1-carbamoyl-propyl)-amide, a cyclic tetrapeptide derivative. The chemical structure of these three active compounds was established on the basis of spectroscopic studies (MS and NMR) and by comparison with data from the literature. According to our biological studies, the pure compounds (1-3) possess antibacterial and antifungal activities.     

Extraction and analysis of ellagic acid from novel complex sources

Ellagic acid (EA) was quantified by reversed-phase high-performance liquid chromatography (RPHPLC) coupled with photodiode array detection (DAD) in five fine-powdered plants collected from the semiarid region of Mexico. Samples analysed included Jatropha dioica branches (Dragon’s blood), Euphorbia antisyphyllitica branches (Candelilla), Turnera diffusa Willd leaves (Damiana), Flourensia cernua leaves (hojasén) and Punica granatum husk (pomegranate) at two maturity stages (“turning” or intermediate and maturated fruit, considered as positive controls). The results demonstrated high EA concentrations in all tested samples which are novel sources of this natural antioxidant. The method developed for the EA analysis is fast and it showed an excellent linearity range, repeatability, intra-and inter-day precision and accuracy with respect to the methods reported for the EA analysis.     

Bounds for the Perron root, singularity/nonsingularity conditions, and eigenvalue inclusion sets

Using a unified approach based on the monotonicity property of the Perron root and its circuit extension, a series of exact two-sided bounds for the Perron root of a nonnegative matrix in terms of paths in the associated directed graph is obtained. A method for deriving the so-called mixed upper bounds is suggested. Based on the upper bounds for the Perron root, new diagonal dominance type conditions for matrices are introduced. The singularity/nonsingularity problem for matrices satisfying such conditions is analyzed, and the associated eigenvalue inclusion sets are presented. In particular, a bridge connecting Gerschgorin disks with Brualdi eigenvalue inclusion sets is found. Extensions to matrices partitioned into blocks are proposed.     

Michael reaction. IV. NaNH2 catalyzed one stage reaction between phenylacetic acid dialkylamides and cinnamic acid methyl ester or dialkylamides. Influence of reaction conditions on the stereochemistry

The NaNH₂ catalyzed one stage reaction between phenylacetic acid dialkylamides and cinnamic acid methyl ester or dialkylamides was studied under various conditions. Conditions were found for easy preparation of each of the both possible diastereomeric derivatives of 2,3-diphenylglutaric acid. It was proved that catalytic amounts of NaNH₂ take part in the reaction. It is assumed that the observederythro/threo equilibrium ratios are determined by an isomerization via two different carbanions (at C₂ and C₄) of the reaction products.Part III:J. Stefanovsky andL. Viteva, Comun. Dept. Chem. Bulg. Acad. Sci.4, 159 (1971).     

Extended Antipodal Theorems

In infinite-dimensional Hilbert spaces, we prove that the iterative sequence generated by the extragradient method for solving pseudo-monotone variational inequalities converges weakly to a solution. A class of pseudo-monotone variational inequalities is considered to illustrate the convergent behavior. The result obtained in this note extends some recent results in the literature; especially, it gives a positive answer to a question raised in Khanh (Acta Math Vietnam 41:251–263, 2016).     

Study of ProtoPorphyrin IX Elimination by Body Excreta: A new Noninvasive Cancer Diagnostic Method?

This paper describes the elimination of porphyrins by feces. It was demonstrated that porphyrin accumulates substantially more in tumors than in normal tissues, and consequently more PPIX reaches the blood of patients and animals with tumors, and then, it needs to be eliminated. The fluorescence of feces revealed that there are large amounts of PPIX in the excreta of animals with cancer comparing with healthy animals. The autofluorescence of feces porphyrin extracted with acetone was analyzed using fluorescence spectroscopy of animals inoculated with DU145 cells into the prostate and healthy animals to monitor the PPIX concentration. Emission spectra were obtained by exciting the samples at 405 nm. Significant differences were observed in autofluorescence intensities measured in the 575–725 nm spectral regions for the studied groups. The results showed a noninvasive, simple, rapid and sensitive method to detect cancer by feces analysis.     

Structural studies of some o-substituted S-phenyl thiobenzoates. I. Crystal structure of S-phenyl o-chlorothiobenzoate and S-phenyl o-bromothiobenzoate

Structural characteristics ofS-phenylo-chlorothiobenzoate (I) andS-phenylo-bromothiobenzoate (II) have been investigated by single crystal X-ray diffraction. It was shown that the crystals are isomorphous and crystallize in the monoclinic space groupP2₁ withZ=2. The unit cell parameters are:a=10.150(3),b=7.672(2),c=7.595(2) Å,=91.28(1)° for C₁₃H₉ClOS (compoundI) anda=10.141(3),b=7.764(2),c=7.653(2) Å,=90.14(3)° for C₁₃H₉BrOS (compoundII). The structures were solved by heavy-atom methods and refined by full-matrix least-squares, from room-temperature data collected with a Philips PW 1100 diifractometer, to conventionalR factors of 0.056 forI and 0.044 forII. The structures consist of independent molecules held together by intermolecular interactions. Molecular packing is influenced by the presence ofo-substituted Cl or Br atoms. The Cl atoms in structureI as well as the Br ones in structureII are directed to the centers of the pi-electronic system of theo-substituted phenyl rings belonging to the neighboring molecules. The six ClC and BrC distances range from 3.651(10) to 3.869(9) Å and from 3.644(6) to 3.890(6) Å, respectively. The C1 (or Br) atom is additionally directed towards the two carbon atoms (C3 and C4) in anothero-substituted phenyl ring, the C1lC and BrC distances being 3.786(9) and 3.849(10) Å inI and 3.727(6) and 3.881(6) Å inII. The torsion angle C6-C7-S-C8 is-170.2(7)° inI and 168.6(4)° inII. The angles between the planar O-C7-S central fragment of the molecule, on the one hand, and theo-substituted phenyl ring, on the other, are 113.9(3)° in I and 110.9(2)° inII. The corresponding values for the angles between the O-C7-S fragment and the nonsubstituted phenyl ring are 115.8(3)° and 114.3(2)° in compoundsI andII, respectively.