排序方式: 共有36条查询结果,搜索用时 15 毫秒
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A Comparative Study of Cellular Uptake and Subcellular Localization of Doxorubicin Loaded in Self‐Assemblies of Amphiphilic Copolymers with Pendant Dendron by MDA‐MB‐231 Human Breast Cancer Cells 下载免费PDF全文
Geetha Viswanathan Yu‐Hsuan Hsu Siew Hui Voon Toyoko Imae Ampornphan Siriviriyanun Hong Boon Lee Lik Voon Kiew Lip Yong Chung Shin‐ichi Yusa 《Macromolecular bioscience》2016,16(6):882-895
Previously synthesized amphiphilic diblock copolymers with pendant dendron moieties have been investigated for their potential use as drug carriers to improve the delivery of an anticancer drug to human breast cancer cells. Diblock copolymer (P71D3)‐based micelles effectively encapsulate the doxorubicin (DOX) with a high drug‐loading capacity (≈95%, 104 DOX molecules per micelle), which is approximately double the amount of drug loaded into the diblock copolymer (P296D1) vesicles. DOX released from the resultant P71D3/DOX micelles is approximately 1.3‐fold more abundant, at a tumoral acidic pH of 5.5 compared with a pH of 7.4. The P71D3/DOX micelles also enhance drug potency in breast cancer MDA‐MB‐231 cells due to their higher intracellular uptake, by approximately twofold, compared with the vesicular nanocarrier, and free DOX. Micellar nanocarriers are taken up by lysosomes via energy‐dependent processes, followed by the release of DOX into the cytoplasm and subsequent translocation into the nucleus, where it exert its cytotoxic effect.
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Wee LH Wiktor C Turner S Vanderlinden W Janssens N Bajpe SR Houthoofd K Van Tendeloo G De Feyter S Kirschhock CE Martens JA 《Journal of the American Chemical Society》2012,134(26):10911-10919
Porous solids with organized multiple porosity are of scientific and technological importance for broadening the application range from traditional areas of catalysis and adsorption/separation to drug release and biomedical imaging. Synthesis of crystalline porous materials offering a network of uniform micro- and mesopores remains a major scientific challenge. One strategy is based on variation of synthesis parameters of microporous networks, such as, for example, zeolites or metal-organic frameworks (MOFs). Here, we show the rational development of an hierarchical variant of the microporous cubic Cu(3)(BTC)(2) (BTC = 1,3,5-benzenetricarboxylate) HKUST-1 MOF having strictly repetitive 5 nm wide mesopores separated by uniform microporous walls in a single crystal structure. This new material coined COK-15 (COK = Centrum voor Oppervlaktechemie en Katalyse) was synthesized via a dual-templating approach. Stability was enhanced by Keggin type phosphotungstate (HPW) systematically occluded in the cavities constituting the walls between the mesopores. 相似文献
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Joseph Lik Hang Chau Hsien-Wen Liu 《Journal of Physics and Chemistry of Solids》2009,70(10):1385-5707
This work reports the preparation of well-dispersed surface-modified titiania nanoparticles in organic solvents. Different types of surface-modified titania nanoparticles can be incorporated into epoxy matrix to form hybrid nanocomposites. The hybrid nanocomposite films have higher refractive index than pure epoxy system. The refractive index can be tuned by using different forms of titania nanoparticles and by changing the titania solid content. The titania solid content in the epoxy matrix can be more than 70 wt% without affecting the optical transparency of the hybrid film. 相似文献
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We study the problem of heat conduction in a mass-disordered two-dimensional harmonic crystal. Using two different stochastic heat baths, we perform simulations to determine the system size (L) dependence of the heat current (J). For white noise heat baths we find that J approximately 1/L(alpha) with alpha approximately equal to 0.59, while correlated noise heat baths give alpha approximately equal to 0.51. A special case with correlated disorder is studied analytically and gives alpha=3/2, which agrees also with results from exact numerics. 相似文献
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Hung LC Basri M Tejo BA Ismail R Nang HL Abu Hassan H May CY 《Colloids and surfaces. B, Biointerfaces》2011,87(1):180-186
Heat-sensitive bioactive compounds such as β-carotene and tocols, are widely used in the pharmaceutical and cosmetic fields. Their chemical stability in delivery systems is one of the major concerns in the production of nanostructured lipid carriers (NLCs). A previously established high-temperature high-pressure homogenisation technique involved in the preparation of NLCs can cause degradation of heat-sensitive compounds. Therefore, a novel preparation process needs to be developed to minimise the degradation of heat-sensitive active compounds during the preparation of NLCs. In this work, modified methods A and B were designed to minimise the degradation of β-carotene and tocols during the production of NLCs. These methods improved the chemical stability of heat-sensitive bioactive compounds (β-carotene and tocols) significantly compared to the previously established method. The physical stability of the formulation was maintained throughout study duration. 相似文献