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71.
本文讨论了由N个同型部件和一个服务设备组成的机器服务模型,在服务设备绝对可靠,或服务设备具有指数寿命,修理工对其修理的时间为PH分布,这两种情况下求得了系统的平稳概率分布,从而求得机器系统和服务设备的稳态可靠性指标,并证明了它们的首次失效时间均服从PH分布,服务设备和修理工的忙期亦服从PH分布. 相似文献
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Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry 总被引:1,自引:0,他引:1
Gjerde J Kisanga ER Hauglid M Holm PI Mellgren G Lien EA 《Journal of chromatography. A》2005,1082(1):6-14
We have developed a method for the determination of tamoxifen (tam) and its metabolites 4-hydroxytamoxifen (4OHtam), N-demethyltamoxifen (NDtam), N-dedimethyltamoxifen (NDDtam), tamoxifen-N-oxide (tamNox), and 4-hydroxy-N-demethyltamoxifen (4OHNDtam) in 50 microl human serum. Serum proteins were precipitated with acetonitrile. Deuterated-tamoxifen (D5 tam) was added as internal standard. Sample supernatant was injected into an on-line reversed-phase extraction column coupled with a C18 analytical column and analytes were detected by tandem mass spectrometry. The lower limits of quantification were 0.25 ng/mL for 4OHtam, NDtam and tam, 1.0 ng/mL for NDDtam and tamNox. Ranges of within- and between-day variation were 2.9-15.4% and 4.4-12.9%, respectively. 相似文献
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Milena Popova Boryana Trusheva Ralitsa Chimshirova Daniela Antonova Kamelia Gechovska Le Nguyen Thanh Nguyen Thi Phuong Lien Diep Thi Lan Phuong Vassya Bankova 《Molecules (Basel, Switzerland)》2022,27(22)
The present study aimed to analyze and compare the chemical profile and antioxidant capacity of propolis from different bee species and different regions. The chemical profiles of propolis from six stingless bee species (Tetragonula iridipennis, T. laeviceps, Lepidotrigona terminata, L. ventralis, Lisotrigona carpenteri and Homotrigona apicalis) collected from a total of eight locations in Vietnam were investigated by gas chromatography–mass spectrometry (GC-MS). More than 70 compounds were identified, amongst which phenolic lipids (cardanols, resorcinols and anacardic acids), aromatic acids, triterpenes and xanthones. Taxonomic markers for Mangifera indica (phenolic lipids and cycloartane triterpenes) were detected in propolis from bees of the genera Tetragonula and Lepidotrigona, although in different amounts, whereas propolis from H. apicalis was characterized by triterpenes of the amyrine type, typical of dipterocarp trees. A clear discrimination between both groups was observed by principal component analysis (PCA) and partial least squares–discriminant analysis (PLS-DA). Propolis from Tetragonula and Lepidotrigona spp. and from Lisotrigona carpenteri, which is rich in xanthones, possesses higher radical scavenging and ferric-reducing capacity than that from H. apicalis. Propolis produced by all six stingless bee species in Vietnam was analyzed for the first time. In addition, this is the first report on L. carpenteri propolis. 相似文献
77.
The phytochemical investigation of Placolobium vietnamense stems led to the isolation of a new isoflavone derivative (1) and three new benzil derivatives (2–4), together with four known pyranoisoflavones (5–8). The structures of all isolated compounds were determined on the basis of extensive spectroscopic analyses, including NMR and HRMS spectral data, as well as comparison of their spectroscopic data with those reported in the literature. The cytotoxicity of all isolated compounds was assessed against the human liver hepatocellular carcinoma (Hep G2) cell line, and compound 1 displayed the most significant cytotoxicity with an IC50 value of 8.0 μM. Furthermore, all isolated compounds were also tested for their inhibitory activity against NO production in RAW 264.7 macrophages. Of these, compound 1 exhibited the strongest inhibitory efficacy against the LPS-induced NO production with the IC50 value of 13.7 μM. 相似文献
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Three new flavonoid derivatives, melodorones A–C (1–3), together with four known compounds, tectochrysin (4), chrysin (5), onysilin (6), and pinocembrin (7), were isolated from the stem bark of Melodorum fruticosum. Their structures were determined on the basis of extensive spectroscopic methods, including NMR and HRESIMS, and by comparison with the literature. Compounds 1–7 were evaluated for their in vitro α-glucosidase inhibition and cytotoxicity against KB, Hep G2, and MCF7 cell lines. Among them, compound 1 exhibited the best activity against α-glucosidase and was superior to the positive control with an IC50 value of 2.59 μM. On the other hand, compound 1 showed moderate cytotoxicity toward KB, Hep G2, and MCF7 cell lines with the IC50 values of 23.5, 19.8, and 23.7 μM, respectively. These findings provided new evidence that the stem bark of M. fruticosum is a source of bioactive flavonoid derivatives that are highly valuable for medicinal development. 相似文献
79.
Jin‐Cherng Lien Yu‐Dong Jiang Chun‐Jen Chen Sheng‐Chu Kuo Li‐Jiau Huang 《中国化学会会志》2008,55(5):1160-1165
In continuing search for novel cell differentiation agents, a series of derivatives of indole‐3‐acetic acid and indole‐3‐carboxylic acid were prepared and tested against HL‐60 cells for their differentiation and antiproliferation activities. Among them, N‐ethyl‐1‐benzylindole‐3‐carboxamide ( 14 ) was the most potent, whereas N‐methyl 1‐benzylindole‐3‐acetamide ( 5 ) and N‐methyl 1‐benzylindole‐3‐carboxamide ( 13 ) synergistically potentiated with all‐trans‐retinoic acid to induce cell differentiation as well as antiproliferation. Our results indicate that these compounds are effective cell differentiation and antiproliferation agents in combination with retinoic acid. 相似文献
80.
San‐Lien Wu Chen‐Yang Hong Kuan‐Yi Wu Shih‐Ting Lan Chou‐Ting Hsieh Prof. Hsin‐Lung Chen Prof. Chien‐Lung Wang 《化学:亚洲杂志》2016,11(14):2011-2015
Molecular conformation and the assembly structure determine the spatial arrangements of the constituent units and the functions of a molecule. Although, fullerene hexa‐adducts (FHAs) have been known as functional materials with great versatility, their conformational preferences and phase stability remain a complicate issue. By choosing bithiophene (T2) and dodecyl bithiophene (C12T2) as the peripheral units of FHA, and using microscopic, scattering and diffraction characterizations, our study reveals how the intramolecular interaction and environmental stimulus affects the conformational preferences and phase stability of FHAs. 相似文献