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61.
62.
tefica Horvat Lidija Varga Jaroslav Horvat Andreas Pfützner Haryadi Suhartono Helga Rübsamen-Waigmann 《Helvetica chimica acta》1991,74(5):951-955
A series of [Leu5]enkephalin-related glycoconjugates with an ester-, ether-, or amide-type linkage were synthesized and evaluated for antiviral activity against HIV-1 in a cell-culture system using peripheral blood lymphocytes. All tested glycoconjugates exhibited a certain antiviral activity which was significantly higher than the activity of the parent peptide compound itself. These results indicate that synthetic glycoconjugates of opioid peptides are good candidates for the development of anti-HIV agents. 相似文献
63.
Mojca Čakić Semenčić Maja Dropučić Lidija Barišić Krešimir Molčanov Vladimir Rapić 《Structural chemistry》2007,18(3):273-278
N-Acetyl-(1-ferrocenylethyl)amine (8) was synthesized by N-acylation of (1-ferrocenylethyl)amine (7) in 84% yield. Reaction of N-acetyl-[1-(1′-bromo-ferrocenyl)ethyl]amine (4) (which was prepared by multistep sequence starting from bromoferrocene) with n-BuLi/ClCOOEt gave 77% of N-acetyl-N-ethoxycarbonyl-(1-ferrocenylethyl)amine (6) instead of the expected ethyl 1′-[1-(acetamido)ethyl]ferrocene-1-carboxylate (5). Both structures were undoubtedly confirmed by (HR)MS spectroscopy and single crystal X-ray structure analysis. 相似文献
64.
A new spectrophotometric method for the determination of microamounts of tungsten(VI) with rutin has been developed. The effect of a large number of foreign ions was investigated, and the separation and determination of tungsten in the presence of the interfering ions examined are presented. 相似文献
65.
Branko Stanovnik Borut Furlan Marko Kupper Lidija Male Anton timac Miha Tiler Marko
li
ar 《Journal of heterocyclic chemistry》1988,25(2):393-398
The nucleophilic and electrophilic substitutions of 6-substituted 9,9-dimethyl-9H-imidazo[1,2-b]pyrazolo- [4,3-d]pyridazines 2 , nucleophilic substitutions of 6-substituted 9,9-dimethyl-9H-pyrazolo[4,3-d]-s-triazolo- [4,3-b]pyridazines 7 and some other transformations to give compounds 3 and 8 , respectively, were studied. It was shown that both heterocyclic systems are stable under the conditions employed in these transformations. 相似文献
66.
Lidija Pezdirc 《Tetrahedron》2007,63(4):991-999
A library of 15 1,6,7,9-tetrasubstituted 6,7,9,9a-tetrahydro-5H-pyrazolo[1,2-a]pyrrolo[3,4-c]pyrazole-1,3,5(2H,3aH)-triones was prepared by combinatorial stereoselective cycloadditions of (1Z,4R∗,5R∗)-1-arylmethylidene-4-benzoylamino-5-phenylpyrazolidin-3-on-1-azomethine imines to N-substituted maleimides. Stereochemistry was controlled by the stereodirecting phenyl group at position-3 and by the ortho-substituents at the aromatic ring at position-1′ in azomethine imines. Consequently, two sets of diastereomeric cycloadducts were obtained, one set from the ortho-unsubstituted dipoles and the other set from the ortho-disubstituted dipoles. 相似文献
67.
Gabriela Biliuta Lidija Fras Simona Strnad Valeria Harabagiu Sergiu Coseri 《Journal of polymer science. Part A, Polymer chemistry》2010,48(21):4790-4799
Three different nonpersistent radicals bearing >NO? moiety have been used to oxidize the viscose fibers at room temperature and alkaline pH. The generation of the free radical species was achieved in situ, from their corresponding ? OH precursors: 1‐hydroxybenzotriazole, violuric acid, and N‐hydroxy‐3,4,5,6‐tetraphenylphthalimide. Three different routes were used: (i) in the presence of metallic cocatalyst (lead tetraacetate), (ii) under metal‐free conditions (anthraquinone as organic cocatalyst), and (iii) a homolytically scission of ? OH bond through a 365‐nm UV irradiation. The oxidized fibers were subjected to attenuated total reflection FTIR characterization, potentiometric titration, wide angle X‐ray, energy dispersive X‐ray analyses, microscopic investigations, and solid‐state 13C‐NMR. The patterns of CP/MAS 13C‐NMR spectra revealed that the oxidation occurred at the C6 primary hydroxyl groups of cellulose. Notably, as a result of the introduction of hydrophilic carboxylate groups, the water retention values of the oxidized fibers increased by 35% as compared to the original nonoxidized sample. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010 相似文献
68.
Lidija Urbas Boštjan Košir Matjaž Peterka Boris Pihlar Aleš Štrancar Miloš Barut 《Journal of chromatography. A》2011,1218(17):2432-2437
Monoliths are chromatographic stationary phases, which were specially designed for efficient purification of large biomolecules, like proteins, viruses and DNA. In this work, the small scale monolithic butyl (C4) and styrene-divinyl benzene (SDVB) columns were applied for reversed phase analyses of various degraded influenza viruses. The binding of the HA1 subunit of haemagglutinin to the monolithic columns was confirmed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) and the Western blot. The working linear range was determined as 1.60 × 1010 viral particles/mL to at least 1.64 × 1011 viral particles/mL, the limit of detection was found to be 2.56 × 109 virus particles/mL and the limit of quantification was 5.12 × 109 virus particles/mL. The analytical HPLC method developed with the H1N1 virus was also applicable for the analytics of the HA1 subunit of H3N2 influenza virus and the influenza B virus. 相似文献
69.
Paul S. Baron Juliette E. Neve David Camp Lekha Suraweera Ann Lam John Lai Lidija Jovanovic Colleen Nelson Rohan A. Davis 《Magnetic resonance in chemistry : MRC》2013,51(6):358-363
A focused library based on the marine natural products polyandrocarpamines A ( 1 ) and B ( 2 ) has been designed and synthesised using parallel solution‐phase chemistry. In silico physicochemical property calculations were performed on synthetic candidates in order to optimise the library for drug discovery and chemical biology. A library of ten 2‐aminoimidazolone products ( 3–12 ) was prepared by coupling glycocyamidine and a variety of aldehydes using a one‐step stereoselective aldol condensation reaction under microwave conditions. All analogues were characterised by NMR, UV, IR and MS. The library was evaluated for cytotoxicity towards the prostate cancer cell lines, LNCaP, PC‐3 and 22Rv1. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
70.
Lidija Urbas Peter Brne Boštjan Gabor Miloš Barut Matija Strlič Tatjana Čerk Petrič Aleš Štrancar 《Journal of chromatography. A》2009,1216(13):2689-2694
Human serum albumin (HSA) and immunoglobulin G (IgG) represent over 75% of all proteins present in human plasma. These high-abundance proteins prevent the detection of low-abundance proteins which are potential markers for various diseases. The depletion of HSA and IgG is therefore essential for further proteome analysis. In this paper we describe the optimization of conditions for selective depletion of HSA and IgG using affinity and pseudo-affinity chromatography. A BIA Separations CIM (convective interaction media) Protein G disk was applied for the removal of IgG and the Mimetic Blue SA A6XL stationary phase for the removal of HSA. The binding and the elution buffer for CIM Protein G disk were chosen on the basis of the peak shape. The dynamic binding capacity was determined. It was shown to be dependent on the buffer system used and independent of the flow rate and of the concentration of IgG. Beside the binding capacity for the IgG standard, the binding capacity was also determined for IgG in human plasma. The Mimetic Blue SA A6XL column was characterized using human plasma. The selectivity of the depletion was dependent on the amount of human plasma that was loaded on the column. After the conditions on both supports had been optimized, the Mimetic Blue SA A6XL stationary phase was combined with the CIM Protein G disk in order to simultaneously deplete samples of human plasma. A centrifuge spin column that enables the removal of IgG and HSA from 20 μL of human plasma was designed. The results of the depletion were examined using sodium dodecyl sulfate polyacrylamide gel electrophoresis and two-dimensional gel electrophoresis. 相似文献