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121.
Jilek RE Spencer LP Lewis RA Scott BL Hayton TW Boncella JM 《Journal of the American Chemical Society》2012,134(24):9876-9878
Metathesis reactions between uranium tetrachloride and lithium 2,6-diisopropylphenylamide in the presence of 4,4'-dialkyl-2,2'-bipyridyl (R(2)bpy; R = Me, (t)Bu) or triphenylphosphine oxide (tppo) appear to generate bis(imido)uranium(IV) in situ. These extremely reactive complexes abstract chloride from dichloromethane to generate U(NDipp)(2)Cl(R(2)bpy)(2) or U(NDipp)(2)Cl(tppo)(3) (Dipp = 2,6-(i)Pr(2)C(6)H(3)). The preparation of the bromide and iodide analogues U(NDipp)(2)X(R(2)bpy)(2) was achieved by addition of CH(2)X(2) (X = Br, I) to the uranium(IV) solutions. The uranium(V) halides were characterized by X-ray crystallography and found to exhibit linear N-U-N units and short U-N bonds. Electrochemical measurements were made on the chloride bipyridine species, which reacts readily with iodine or ferrocenium to generate bis(imido)uranium(VI) cations. 相似文献
122.
Alexandra van Remoortere René J. M. van Zeijl Nico van den Oever Julien Franck Rémi Longuespée Maxence Wisztorski Michel Salzet André M. Deelder Isabelle Fournier Liam A. McDonnell 《Journal of the American Society for Mass Spectrometry》2010,21(11):1922-1929
MALDI imaging and profiling mass spectrometry of proteins typically leads to the detection of a large number of peptides and
small proteins but is much less successful for larger proteins: most ion signals correspond to proteins of m/z < 25,000. This is a severe limitation as many proteins, including cytokines, growth factors, enzymes, and receptors have
molecular weights exceeding 25 kDa. The detector technology typically used for protein imaging, a microchannel plate, is not
well suited to the detection of high m/z ions and is prone to detector saturation when analyzing complex mixtures. Here we report increased sensitivity for higher
mass proteins by using the CovalX high mass HM1 detector (Zurich, Switzerland), which has been specifically designed for the
detection of high mass ions and which is much less prone to detector saturation. The results demonstrate that a range of different
sample preparation strategies enable higher mass proteins to be analyzed if the detector technology maintains high detection
efficiency throughout the mass range. The detector enables proteins up to 70 kDa to be imaged, and proteins up to 110 kDa
to be detected, directly from tissue, and indicates new directions by which the mass range amenable to MALDI imaging MS and
MALDI profiling MS may be extended. 相似文献
123.
Arylsilanes are efficient reagents for the gold-catalyzed oxyarylation of alkenes (21 examples, up to 85% isolated yield). Using commercially available Ph(3)PAuCl and readily prepared, benign arylsilanes, these two- and three-component reactions proceed smoothly in air. The oxidant, Selectfluor, not only facilitates entry to the Au(I/III) manifold but also provides a fluoride anion for silane activation, thereby avoiding the need for addition of a stoichiometric base. 相似文献
124.
Liam P. Spencer Ping Yang Brian L. Scott Enrique R. Batista James M. Boncella 《Comptes Rendus Chimie》2010,13(6-7):758-766
Novel cis- and trans-bis(imido) uranium disulfonamide derivatives have been prepared from iodide metathesis reactions between two equivalents of K[N(Me)(SO2Ar’)] (Ar’ = 4-Me-C6H4) and U(NtBu)2(I)2(L)x (L = OPPh3, x = 2; Me2bpy, x = 1; Me2bpy = 4,4’-dimethyl-2,2’-bipyridyl). These bis(amide) derivatives serve as useful precursors for the synthesis of the trans-diphenolate complex U(NtBu)2(O-2-tBuC6H4)2(OPPh3)2 (5), cis- and trans-dithiolate complexes U(NtBu)2(SPh)2(L)x (L = OPPh3 (6); Me2bpy (7)), and cis- and trans-dihalide complexes with the general formulas U(NtBu)2(X)2(L)x (X = Cl, L = OPPh3 (8), L = Me2bpy (10); X = Br, L = OPPh3 (9), L = Me2bpy (11)). DFT calculations performed on the trans-dihalide series U(NtBu)2(X)2(L)2 and the UO22+ analogues UO2X2(OPPh3)2 suggest that the uranium centers in the [U(NtBu)2]2+ ions possess more covalent character than analogous UO22+ derivatives but that the U-X bonds in the U(NtBu)2X2L2 complexes possess a more ionic nature. 相似文献
125.
Walsh AJ O'Dowd JA Bessler VM Shi K Smyth F Dailey JM Kelleher B Barry LP Ellis AD 《Optics letters》2012,37(10):1769-1771
An experimental method for characterizing the time-resolved phase noise of a fast switching tunable laser is discussed. The method experimentally determines a complementary cumulative distribution function of the laser's differential phase as a function of time after a switching event. A time resolved bit error rate of differential quadrature phase shift keying formatted data, calculated using the phase noise measurements, was fitted to an experimental time-resolved bit error rate measurement using a field programmable gate array, finding a good agreement between the time-resolved bit error rates. 相似文献
126.
Weinstein JA Tierney MT Davies ES Base K Robeiro AA Grinstaff MW 《Inorganic chemistry》2006,45(11):4544-4555
A general route for synthesis of six structurally similar Pt(II) diimine thiolate/phenolates chromophores possessing bulky phenolate or thiolate ligands is reported. The Pt chromophores were characterized using an array of techniques including 1H, 13C, and 195Pt NMR, absorption, emission, (spectro)electrochemistry, and EPR spectroscopy. Systematic variation of the electronic structure of the Pt(II) chromophores studied was achieved by (i) changing solvent polarity; (ii) substituting oxygen for sulfur in the donor ligand; (iii) alternating donor ligands from bis- to di-coordination; and (iv) changing the electron donating/withdrawing properties of the ligand(s). The lowest excited state in these new chromophores was assigned to a [charge-transfer-to-diimine] transition from the HOMO of mixed Pt/S (or Pt/O) character on the basis of absorption and emission spectroscopy, UV/vis (spectro)electrochemistry, and EPR spectroscopy. One of the chromophores, Pt(dpphen)(3,5-di-tert-butyl-catecholate) represents an example of a Pt(II) diimine phenolate chromophore that possesses a reversible oxidation centered predominantly on the donor ligand. Results from EPR spectroscopy indicate participation of the Pt(II) orbitals in the HOMO. There is a dramatic difference in the photophysical properties of carborane complexes compared to other mixed-ligand Pt(II) compounds, which includes room-temperature emission and photostability. The charge-transfer character of the lowest excited state in this series of chromophores is maintained throughout. Moreover, the absorption and emission energies and the redox properties of the excited state can be significantly tuned. 相似文献
127.
In this paper the linewidth of widely tunable SG-DBR lasers has been investigated theoretically and experimentally. We demonstrate experimentally the importance of obtaining low linewidth operation for the application of SG-DBR laser with advanced modulation format transmission. This is achieved by choosing two sets of tuning currents for an SG-DBR laser that give the same wavelength channel and good SMSR, but different linewidths. When the laser is employed in a DPSK system only the operating point (the set of drive currents used to obtain specific output characteristics) that portrays low linewidth achieves error free transmission. This work shows that although calibration of tunable lasers is normally based on achieving sufficient SMSR and output power, it will be important to consider the linewidth parameter as these lasers begin to be used in more spectrally efficient WDM systems employing advanced modulation formats. The simulation results illustrate that the operating points which achieve narrow linewidth are correlated with those that exhibit low threshold current. This finding may be used for calibration of SG-DBR lasers to achieve minimum linewidth at each operating wavelength. 相似文献
128.
Recent reports indicate that the crystallization of clathrate hydrates occurs in multiple steps that involve amorphous intermediates and metastable clathrate crystals. The elucidation of the reaction coordinate for clathrate crystallization requires the use of order parameters able to identify the reactants, products, and intermediates in the crystallization pathway. Nevertheless, existing order parameters cannot distinguish between amorphous and crystalline clathrates or between different clathrate crystals. In this work, we present the first set of order parameters that discern between the sI and sII clathrate crystals, the amorphous clathrates, the blob of solvent-separated guests and the liquid solution. These order parameters can be used to monitor the advance of the crystallization and for the efficient implementation of methods to sample the rare clathrate nucleation events in molecular simulations. We illustrate the use of these order parameters in the analysis of the growth and the dissolution of clathrate crystals and the spontaneous nucleation and growth of clathrates under conditions of high supercooling. 相似文献
129.
Amy R. Marts Samuel M. Greer Daniel R. Whitehead Tessa M. Woodruff Robert M. Breece Sarah W. Shim Shannon N. Oseback Elizabeth T. Papish Faith E. Jacobsen Seth M. Cohen David L. Tierney 《Applied magnetic resonance》2011,40(4):501-511
The EPR spectra of high-spin Co(II) systems typically consist of poorly resolved resonances, broadened by a combination of large g-anisotropy, sizable spin?Corbit couplings and admixture of excited state character into the magnetic ground state. In this report, we present dual-mode EPR studies of a set of 4-, 5- and 6-coordinate Co(II) complexes, as well as cobalt-substituted carbonic anhydrase, with and without a bidentate chelator. The suite of samples shows surprisingly large signals in parallel mode that cannot be accounted for by imperfections in the isolation of the parallel and perpendicular polarizations. To our knowledge, this is the first report of parallel polarization EPR from a Kramers system. We suggest that the parallel mode signals arise from admixture of excited state character into the ground state, and that the methods employed here may provide a means of quantitatively assessing the extent of mixing. 相似文献
130.
Dr. Liam D. Adair Natalie Trinh Pauline M. Vérité Prof. Denis Jacquemin Prof. Katrina A. Jolliffe Elizabeth J. New 《Chemistry (Weinheim an der Bergstrasse, Germany)》2020,26(44):10064-10071
Fluorescent sensors are a vital research tool, enabling the study of intricate cellular processes in a sensitive manner. The design and synthesis of responsive and targeted probes is necessary to allow such processes to be interrogated in the cellular environment. This remains a challenge, and requires methods for functionalisation of fluorophores with multiple appendages for sensing and targeting groups. Methods to synthesise more structurally complex derivatives of fluorophores will expand their potential scope. Most known 4-amino-1,8-naphthalimides are only functionalised at imide and 4-positions, and structural modifications at additional positions will increase the breadth of their utility as responsive sensors. In this work, methods for the incorporation of a hypoxia sensing group to 4-amino-1,8-naphthalimide were evaluated. An intermediate was developed that allowed us to incorporate a sensing group, targeting group, and ICT donor to the naphthalimide core in a modular fashion. Synthetic strategies for attaching the hypoxia sensing group and how they affected the fluorescence of the naphthalimide were evaluated by photophysical characterisation and time-dependent density functional theory. An extracellular hypoxia probe was then rationally designed that could selectively image the hypoxic and necrotic region of tumour spheroids. Our results demonstrate the versatility of the naphthalimide scaffold and expand its utility. This approach to probe design will enable the flexible, efficient generation of selective, targeted fluorescent sensors for various biological purposes. 相似文献