Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene

ABSTRACT

Herein we describe a simple method for the synthesis of polymer nanocarrier for the doxorubicin delivery. The nanocarrier consists of N-methyl-glucamine resorcinarenes that are covalently bound to phenylboronic acid. The nanocarrier is stable at normal pH but is hydrolysed at pH below 6. It demonstrates low cytotoxicity and haemolytic activity. Doxorubicin was successfully loaded into the nanocarriers cavity and its release occurs at pH. Flow cytometry data showed that the carrier improves the penetration of doxorubicin into M-Hela cancer cell lines. The encapsulated doxorubicin demonstrates higher cytotoxicity towards the cancer cells.     

Synthesis of novel mannopyranosyl betulinic acid phosphoniohexyl ester

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Thermal magnetic investigation of the decomposition of NixMn1−xC2O4·2H2O

The systems Ni_xMn_1?xC₂O₄·2H₂O (x = 0.11, 0.34) are characterized by XRD, SEM, TG/DTA, EGA-MS and magnetic measurements. The last confirmed that the studied samples are real solid solutions. The SEM reveals that the morphology depends on both the excess of C₂O₄^2? and the initial ratio Ni/Mn. The thermal magnetic investigations (in situ) show that: (i) the presence of Ni in Ni_xMn_1?xC₂O₄·2H₂O leads to decreasing in the decomposition temperature in regard to that of the manganese oxalate; (ii) upon increasing the Ni content the temperature of decomposition (in air) is growing up; (iii) the presence of Ni stabilizes the manganese with respect to oxidation, in spite of the occurring process of decomposition.     

Reactions in the M(HCOO)2-CS(NH2)2-H2O (M = Mg, Mn, Cd) systems at 25°C

Complex formation in the M(HCOO)₂-CS(NH₂)₂-H₂O (M = Mg, Mn, Cd) systems at 25°C is studied using the isothermal solubility method. In the Cd(HCOO)₂-CS(NH₂)₂-H₂O system, a congruently dissolving compound Cd(HCOO)₂ · 2CS(NH₂)₂ is found and characterized by X-ray powder diffraction and IR spectroscopy. The Mg(HCOO)₂-CS(NH₂)₂-H₂O and Mn(HCOO)₂-CS(NH₂)₂-H₂O systems are eutonics at this temperature. Data on carbamide and thiocarbamide complexes of divalent metal formates are systematized.     

Self-assembled fractal hybrid dendrites from water-soluble anionic (thia)calix[4] arenes and Ag<Superscript>+</Superscript>

Novel water-soluble anionic p-tert-butylthiacalix[4]arene with propanesulfonate fragments has been synthesized. Alkylation of the lower rim of thiacalix[4]arene in the presence of NaH/THF led to cone conformation instead of the expected 1,3-alternate conformer due to metal template effect. The presence of supramolecular associates at the critical micelle concentration of 1.65 · 10^?5 M were investigated in aqueous solutions by a combination of different techniques (DLS and conductivity). It was observed that the macrocyclic platform decreases the CMC by tenfold as compared with non-macrocycle analogs. A simple approach for the design of stable monodisperse Ag-based nanoaggregates (near 95 nm) containing ionic Ag and organic ligand–thiacalix[4]arene sulfo derivative in water has been developed. Self-assembled fractal hybrid nanodendrites consisting of water-soluble anionic (thia)calix[4]arenes and Ag⁺ have been obtained in a single step under mild conditions.

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Aggregation behavior of the surfactant bearing pyrrolidinium head group in the presence of polyacrylic acid

Russian Chemical Bulletin - The aggregation characteristics of binary systems based on a novel pyrrolidinium surfactant with the hexadecyl hydrocarbon tail and hydroxyethyl fragment at the nitrogen...     

Synthesis of f luorescein-labeled oligonucleotides bearing a tag in position 2′ of modified adenosine and arabinoadenosine

Oligonucleotide conjugates containing fluorescein residues in the sugar-phosphate back-bone were synthesized by the standard solid-phase phosphoramidite method using phosphor-amidites of 9-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-2-methoxalylamino-β-D-ribofuranosyl]-and 9-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-2-methoxalylamino-β-D-arabinofuranosyl]-N ⁶-benzoyladenine. The relative efficiency of the oligonucleotide synthesis with modified phosphoramidites was estimated. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1618–1624, September, 2006.     

Retention of diphenyls,terphenyls, phenylalkanes and fluorene on graphitized thermal carbon black

Summary This paper defines values of retention volumes for zero surface coverage (Henry's constant) at different temperatures, retention indices and variations of the internal energy (differential heats of adsorption) of diphenyl and its alkyl derivatives, terphenyls, diphenylmethane, triphenylmethane, diphenylethanes and fluorene on graphitized thermal carbon black (GTCB). Adsorption on GTCB takes place in accordance with the geometry of these molecules, the strongest adsorption being observed for para-terphenyl with least inhibited internal rotation of the molecule, while the weakest adsorption occurs for 2,6,2,6-tetramethyldiphenyl with the most inhibited internal rotation of the molecules. The flat molecules of fluorene are adsorbed on GTCB more readily than the nonflat molecules of diphenylmethane.