A Promising Material for Selective Sensing Biomarker Gas Molecules

Russian Journal of Physical Chemistry A - The interaction of many biomarker gas molecules on pure, AlB-doped and GaB-doped boron nitride nanotube was studied by the density functional theory method...     

Synthesis,X‐ray Analysis,and Biological Activities of Novel Oxazolidinethiones

Oxazolidinethione compounds were synthesized starting from racemic and enantiopure β‐amino alcohols. The molecular structure of oxazolidinethione 6a was elucidated by single‐crystal x‐ray crystallography. Oxazolidinethione compounds screened for antimicrobial activity showed mild minimum inhibitory concentration values.     

Synthesis and characterization of new (N‐diphenylphosphino)‐isopropylanilines and their complexes: crystal structure of (Ph2P S)NH?C6H4?4?CH(CH3)2 and catalytic activity of palladium(II) complexes in the Heck and Suzuki cross‐coupling reactions

Three new (N‐diphenylphosphino)‐isopropylanilines, having isopropyl substituent at the carbon 2‐ (1) 4‐ (2) or 2,6‐ (3) were prepared from the aminolysis of chlorodiphenylphosphine with 2‐isopropylaniline, 4‐isopropylaniline or 2,6‐diisopropylaniline, respectively, under anaerobic conditions. Oxidation of 1,2 and 3 with aqueous hydrogen peroxide, elemental sulfur or gray selenium gave the corresponding oxides, sulfides and selenides (Ph₂P?E)NH? C₆H₄? 2‐CH(CH₃)₂, (Ph₂P?E)NH? C₆H₄? 4‐CH(CH₃)₂ and (Ph₂P?E)NH? C₆H₄? 2,6‐{CH(CH₃)₂}₂, where E = O, S, or Se, respectively. The reaction of [M(cod)Cl₂] (M = Pd, Pt; cod = 1,5‐cyclooctadiene) with two equivalents of 1,2 or 3 yields the corresponding monodendate complexes [M((Ph₂P)NH? C₆H₄? 2‐CH(CH₃)₂)₂Cl₂], M = Pd 1d, M = Pt 1e, [M((Ph₂P)NH? C₆H₄? 4‐CH(CH₃)₂)₂Cl₂], M = Pd 2d, M = Pt 2e and [M((Ph₂P)NH? C₆H₄? 2,6‐(CH(CH₃)₂)₂)₂Cl₂], M = Pd 3d, M = Pt 3e, respectively. All the compounds were isolated as analytically pure substances and characterized by NMR, IR spectroscopy and elemental analysis. Furthermore, representative solid‐state structure of [(Ph₂P?S)NH? C₆H₄? 4‐CH(CH₃)₂] (2b) was determined using single crystal X‐ray diffraction technique. The complexes 1d–3d were tested and found to be highly active catalysts in the Suzuki coupling and Heck reaction, affording biphenyls and stilbenes, respectively. Copyright © 2009 John Wiley & Sons, Ltd.     

Phosphorus-Nitrogen Compounds: Part 25. Syntheses,Spectroscopic, Structural and Electrochemical Investigations,Antimicrobial Activities,and DNA Interactions of Ferrocenyldiaminocyclotriphosphazenes

Abstract

The condensation reactions of hexachlorocyclotriphosphazene (N₃P₃Cl₆) with mono (1 and 2) and bisferrocenyldiamines (3–5 and 7) resulted in the formation of tetrachloro mono- (8 and 9) and bisferrocenylspirocyclotriphosphazenes (10–13). In addition the tetramorpholino mono- (8a and 9a) and bisferrocenylphosphazenes (10a–12a) were obtained from the reactions of the corresponding tetrachlorophosphazenes (8–12) with excess morpholine. The structures of all the phosphazenes were determined using FTIR, MS, ¹H, ¹³C, and ³¹P NMR and 2-dimensional NMR techniques. The structures of 9a and 13 were determined by single crystal X-ray diffraction techniques. Cyclic voltammetric investigations of compounds 8a, 9a, and 11a revealed that ferrocene redox centers undergo reversible oxidation. These ferrocenylphosphazenes appear to be quite robust electrochemically. Interactions between the compounds 8a, 9a, 11a, and 12a and pBR322 plasmid DNA were investigated by agarose gel electrophoresis.

[Supplementary materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfer, and Silicon and the Related Elements for the following free supplemental files: Additional text and figures.]     

Synthesis and biological evaluation of 5-methyl-4-phenyl thiazole derivatives as anticancer agents

Abstract

New N-(5-methyl-4-phenylthiazol-2-yl)-2-(substituted thio)acetamides were synthesized and studied for their anticancer activity. The title compounds were procured by reacting 2-chloro-N-(5-methyl-4-phenylthiazol-2-yl)acetamide with some mercapto derivatives. The structural elucidation of the compounds was performed by ¹H-NMR, ¹³C-NMR and LC-MS/MS spectral data and elemental analyses. The synthesized compounds were investigated for their antitumor activities against A549 human lung adenocarcinoma cells and NIH/3T3 mouse embryoblast cell line for determining their selective cytotoxicity. 2-[(1-methyl-1H-tetrazol-5-yl)thio]-N-(5-methyl-4-phenylthiazol-2-yl)acetamide (4c) showed high selectivity, and whose IC₅₀ value was determined as 23.30?±?0.35?µM and >1000?µM against A549 human lung adenocarcinoma cells and NIH/3T3 mouse embryoblast cell lines, respectively. 2-[(1-Methyl-1H-imidazol-2-yl)thio]-N-(5-methyl-4-phenyl thiazol-2-yl)acetamide (4a) and 2-[(1-Methyl-1H-tetrazol-5-yl)thio]-N-(5-methyl-4-phenyl thiazol-2-yl)acetamide (4c) exhibited the highest apoptosis percentage among those tested, but not as high as the standard, cisplatin.     

Synthesis of stereodefined fused δ-hydroxy-γ-lactones from dealkylative cyclization of epoxy-diesters

A dealkylative lactonization of stereodefined aryl-substituted epoxides allows the preparation of densely functionalized fused δ-hydroxy-γ-lactones having three consecutive stereochemically defined stereocenters.     

Synthesis of 1‐(2,6‐Dimethylphenyl)‐N‐hydroxy‐4,4‐dialkyl‐2,5‐dioxo‐N‐aryl‐3‐pyrrolidine‐carboxamides from Reaction of 2,6‐Dimethylphenyl Isocyanide,Alkylidene Meldrum's Acids,and Arylhydroxylamines

Alkylidene Meldrum's acids and 2,6‐dimethylphenyl isocyanide react smoothly in the presence of arylhydroxylamines at room temperature to produce 2,5‐dioxo‐pyrrolidines in fairly high yield.     

Diamminebis(2,4,6‐tribromophenolato‐O)copper(II)

The title compound, [Cu(C₆H₂Br₃O)₂(NH₃)₂], a monomeric centrosymmetric Cu^II complex, crystallizes in the monoclinic system. The CuO₂N₂ coordination sphere is trans planar, [Cu—O 1.943 (5) Å and Cu—N 1.977 (6) Å], with the fifth and sixth coordination sites occupied by Br atoms from the phenoxide ions [Cu—Br 3.129 (1) Å], resulting in an elongated distorted octahedral structure for the CuO₂N₂Br₂ coordination. Each of the NH₃ groups forms two hydrogen bonds with the Br and O atoms of the CuO₂N₂Br₂ moiety of a neighbouring mol­ecule. This arrangement constitutes a one‐dimensional chain along the x axis of the unit cell.     

Synthesis,characterization, crystal structure determination,catalytic activity and thermal study of a new oxidovanadium(IV) Schiff base complex: production of V2O5 nano-particles

A new oxidovanadium(IV) Schiff base complex, VOL₂ (1), containing furfuryl pendant group was synthesized by the reaction of the related bidentate O, N-type Schiff base ligand and VO(acac)₂ in the ratio of 2:1 in methanol in the reflux conditions. The Schiff base ligand and its vanadyl complex were characterized by ¹H-NMR and FT-IR spectra and elemental analysis. The crystal structure of 1 was also determined the single-crystal X-ray analysis. It showed that the metal center located in a distorted tetragonal pyramidal (N₂O₃) geometry in which the two bidentate Schiff base ligands were coordinated to the vanadium(IV) ion in four equatorial positions, and one oxygen atom in its axial position. The catalytic activity of the vanadyl Schiff base complex was elucidated in the epoxidation of cyclooctene as a model substrate. Different reaction parameters were investigated in this reaction and the results showed that it was an effective and selective catalyst in these optimal conditions. Thermogravimetric analysis of 1 showed that it was decomposed in two stages by losing two methoxy groups and other organic residuals, respectively, in the temperature range of 253–532 °C. In addition, the vanadyl Schiff base complex (1) was thermally decomposed in air at 660 °C and the XRD pattern of the obtained solid showed the formation of the V₂O₅ nano-particles with the average size of 52 nm.     

Phosphorus–nitrogen compounds Part 55. Syntheses of 4-methoxybenzylspiro(N/N)cyclotriphosphazenes: chemical,structural and biological properties

Research on Chemical Intermediates - The N3P3 ring of hexachlorocyclotriphosphazene, N3P3Cl6 (1) (HCCP; trimer), was used significantly as a scaffold for the syntheses of...