A transportable gamma spectroscopy system applied to the measurement of fission products

Normally, gamma-ray spectroscopy is performed by equipment positioned in the SLOWPOKE-2 Facility at the Royal Military College; however, there have occasionally been requirements for analyses externally. A transportable gamma spectroscopy system was thus assembled by acquiring a commercially available multichannel analyzer, analysis program and detector, and by designing and constructing a transportable shielding castle. It was then used to take measurements of fission product concentrations at several research reactors.     

Current methods for site-directed structure generation

Summary There has been a rapid growth of interest in techniques for site-directed drug design, fuelled by the increasing availability of structural models of proteins of therapeutic importance, and by studies reported in the literature showing that potent chemical leads can be obtained by these techniques. Structure generation programs offer the prospect of discovering highly original lead structures from novel chemical families. Due to the fact that this technique is more-or-less still in its infancy, there are no case studies available that demonstrate the use of structure generation programs for site-directed drug design. Such programs were first proposed in 1986, and became commercially available in early 1992. They have shown their ability to reproduce, or suggest reasonable alternatives for, ligands in well-defined binding sites. This brief review will discuss the recent advances that have been made in the field of site-directed structure generation.     

Partially finite convex programming,Part I: Quasi relative interiors and duality theory

We study convex programs that involve the minimization of a convex function over a convex subset of a topological vector space, subject to a finite number of linear inequalities. We develop the notion of the quasi relative interior of a convex set, an extension of the relative interior in finite dimensions. We use this idea in a constraint qualification for a fundamental Fenchel duality result, and then deduce duality results for these problems despite the almost invariable failure of the standard Slater condition. Part II of this work studies applications to more concrete models, whose dual problems are often finite-dimensional and computationally tractable.     

Optimally Dense Packings of Hyperbolic Space

In previous work, a probabilistic approach to controlling difficulties of density in hyperbolic space led to a workable notion of optimal density for packings of bodies. In this paper we extend an ergodic theorem of Nevo to provide an appropriate definition of those packings to be considered optimally dense. Examples are given to illustrate various aspects of the density problem, in particular the shift in emphasis from the analysis of individual packings to spaces of packings.     

Efficient N- and C-functionalisation of cyclam macrocycles utilising bisaminal methodology

An efficient synthesis of C-functionalised cyclam macrocycles that employs bisaminal intermediates and allows N-substitution to be controlled is reported.