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121.
Andrew J. McKerrow Marye Anne Fox Jihperng Leu Paul S. Ho 《Journal of polymer science. Part A, Polymer chemistry》1997,35(2):319-327
N,N′-Di-(4-anilino)-1,2,4,5-benzene bis(dicarboximide) was prepared in a three-step synthesis and purified by heating the resulting solid to 200°C. Condensation of the diamino-diimide with several dianhydrides (BPDA, BTDA, and 6-FDA) yielded polyamic acid-imides that could be either thermally or chemically cured to the corresponding alternating copolyimides. Imidization of the polyamic acid-imide to the final polyimide was monitored by FTIR for samples coated on silicon wafers before being thermally cured. Polyimides prepared by chemical imidization were found by thermogravimetric analysis to be stable to temperatures of 600°C. © 1997 John Wiley & Sons, Inc. 相似文献
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Jih-Tung Pai Ming-Wei Hsu Yann-Lii Leu Kuo-Ting Chang Meng-Shih Weng 《Molecules (Basel, Switzerland)》2021,26(17)
Lung cancer is the most commonly diagnosed malignant cancer in the world. Non-small-cell lung cancer (NSCLC) is the major category of lung cancer. Although effective therapies have been administered, for improving the NSCLC patient’s survival, the incident rate is still high. Therefore, searching for a good strategy for preventing NSCLC is urgent. Traditional Chinese medicine (TCM) are brilliant materials for cancer chemoprevention, because of their high biological safety and low cost. Bavachinin, which is an active flavanone of Proralea corylifolia L., possesses anti-inflammation, anti-angiogenesis, and anti-cancer activities. The present study’s aim was to evaluate the anti-cancer activity of bavachinin on NSCLC, and its regulating molecular mechanisms. The results exhibited that a dose-dependent decrease in the cell viability and colony formation capacity of three NSCLC cell lines, by bavachinin, were through G2/M cell cycle arrest induction. Meanwhile, the expression of the G2/M cell cycle regulators, such as cyclin B, p-cdc2Y15, p-cdc2T161, and p-wee1, was suppressed. With the dramatic up-regulation of the cyclin-dependent kinase inhibitor, p21Waf1/Cip1, the expression and association of p21Waf1/Cip1 with the cyclin B/cdc2 complex was observed. Silencing the p21Waf1/Cip1 expression significantly rescued bavachinin-induced G2/M cell accumulation. Furthermore, the expression of p21Waf1/Cip1 mRNA was up-regulated in bavachinin-treated NSCLC cells. In addition, MAPK and AKT signaling were activated in bavachinin-added NSCLC cells. Interestingly, bavachinin-induced p21Waf1/Cip1 expression was repressed after restraint p38 MAPK activation. The inhibition of p38 MAPK activation reversed bavachinin-induced p21Waf1/Cip1 mRNA expression and G2/M cell cycle arrest. Collectively, bavachinin-induced G2/M cell cycle arrest was through the p38 MAPK-mediated p21Waf1/Cip1-dependent signaling pathway in the NSCLC cells. 相似文献
124.
Non-small cell lung cancer (NSCLC), an aggressive subtype of pulmonary carcinomas with high mortality, accounts for 85% of all lung cancers. Drug resistance and high recurrence rates impede the chemotherapeutic effect, making it urgent to develop new anti-NSCLC agents. Recently, we have demonstrated that para-toluenesulfonamide is a potential anti-tumor agent in human castration-resistant prostate cancer (CRPC) through inhibition of Akt/mTOR/p70S6 kinase pathway and lipid raft disruption. In the current study, we further addressed the critical role of cholesterol-enriched membrane microdomain and autophagic activation to para-toluenesulfonamide action in killing NSCLC. Similar in CRPC, para-toluenesulfonamide inhibited the Akt/mTOR/p70S6K pathway in NSCLC cell lines NCI-H460 and A549, leading to G1 arrest of the cell cycle and apoptosis. Para-toluenesulfonamide significantly decreased the cholesterol levels of plasma membrane. External cholesterol supplement rescued para-toluenesulfonamide-mediated effects. Para-toluenesulfonamide induced a profound increase of LC3-II protein expression and a significant decrease of p62 expression. Double staining of lysosomes and cellular cholesterol showed para-toluenesulfonamide-induced lysosomal transportation of cholesterol, which was validated using flow cytometric analysis of lysosome staining. Moreover, autophagy inhibitors could blunt para-toluenesulfonamide-induced effect, indicating autophagy induction. In conclusion, the data suggest that para-toluenesulfonamide is an effective anticancer agent against NSCLC through G1 checkpoint arrest and apoptotic cell death. The disturbance of membrane cholesterol levels and autophagic activation may play a crucial role to para-toluenesulfonamide action. 相似文献
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Synchrotron-based fast micro-tomography is the method of choice to observe in situ multiphase flow and displacement dynamics on the pore scale. However, the image processing workflow is sensitive to a suite of manually selected parameters which can lead to ambiguous results. In this work, the relationship between porosity and permeability in response to systematically varied gray-scale threshold values was studied for different segmentation approaches on a dataset of Berea sandstone at a voxel length of 3 \(\upmu \) m. For validation of the image processing workflow, porosity, permeability, and capillary pressure were compared to laboratory measurements on a larger-sized core plug of the same material. It was found that for global thresholding, minor variations in the visually permissive range lead to large variations in porosity and even larger variations in permeability. The latter is caused by changes in the pore-scale flow paths. Pore throats were found to be open for flow at large thresholds but closed for smaller thresholds. Watershed-based segmentation was found to be significantly more robust to manually chosen input parameters. Permeability and capillary pressure closely match experimental values; for capillary pressure measurements, the plateau of calculated capillary pressure curves was similar to experimental curves. Modeling on structures segmented with hysteresis thresholding was found to overpredict experimental capillary pressure values, while calculated permeability showed reasonable agreement to experimental data. This demonstrates that a good representation of permeability or capillary pressure alone is not a sufficient quality criterion for appropriate segmentation, but the data should be validated with both parameters. However, porosity is the least reliable quality criterion. In the segmented images, always a lower porosity was found compared to experimental values due to micro-porosity below the imaging resolution. As a result, it is recommended to base the validation of image processing workflows on permeability and capillary pressure and not on porosity. Decane-brine distributions from a multiphase flow experiment were modeled in a thus validated \(\upmu \) -CT pore space using a morphological approach which captures only capillary forces. A good overall correspondence was found when comparing (capillary-controlled) equilibrium fluid distributions before and after pore-scale displacement events. 相似文献
127.
The identical two-degrees-of-freedom loudspeaker systems are discussed for synchronization of chaos in this paper. Two methods are used to synchronize two identical chaotic systems with different initial condition: the adaptive control and the Gerschgorin's theorem. Finally we research the parameter identification for two identical two-degrees-of-freedom loudspeaker systems by adaptive control and random optimization method. 相似文献
128.
Yao‐Te Chang Ching‐Fong Shu Chyi‐Ming Leu Kung‐Hwa Wei 《Journal of polymer science. Part A, Polymer chemistry》2003,41(23):3726-3735
We synthesized an AB2‐type monomer, 4‐{4‐[di(4‐aminophenyl)methyl]phenoxy}phthalic acid, which contained one phthalic acid group and two aminophenyl functionalities. The direct self‐polycondensation of the AB2‐type monomer in the presence of triphenylphosphite as an activator afforded a hyperbranched poly(ether imide) with a large number of terminal amino groups. This polymer was characterized with 1H NMR and IR spectroscopy. The degree of branching of the hyperbranched poly(ether imide) was approximately 56%, as determined by a combination of model compound studies and an analysis of 1H NMR spectroscopy integration data. The terminal amino groups underwent functionalization readily. The solubility and thermal properties of the resulting polymers depended on the nature of the chain end groups. In addition, the hyperbranched poly(ether imide) was grafted with polyhedral oligomeric silsesquioxane (POSS). Transmission electron microscopy analysis revealed that the grafted POSS molecules aggregated to form a nanocomposite material. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 41: 3726–3735, 2003 相似文献
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130.
Singer PM Leu G Fordham EJ Sen PN 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2006,183(2):167-177
Pulsed field gradient NMR flow propagators for water flow in Bentheimer sandstone are measured at low fields (1H resonance 2 MHz), using both unipolar and bipolar variants of the pulsed gradient method. We compare with propagators measured at high fields (1H resonance 85 MHz). We show that (i) measured flow propagators appear to be equivalent, in this rock, and (ii) the lower signal to noise ratio at low fields is not a serious limitation. By comparing different pulse sequences, we study the effects of the internal gradients on the propagator measurement at 2 MHz, which for certain rocks may persist even at low fields. 相似文献