Picosecond supercontinuum generation seeded by a weak continuous wave

We experimentally investigate the spectral details of a picosecond supercontinuum pumped at 1064 nm and seeded by a weak continuous wave (～20000 times weaker than the pulse peak power) at several power levels in photonic crystal fibers. Seeding at different wavelengths leads to different spectral details and the effects to the bandwidth of supercontinuum are also distinct. Spectra can be widened when seeded by a continuous wave at 1070 nm and narrowed by ～100 nm when seeded at 1080 nm. The influence is enhanced by increasing the average seeded power.     

Optimized sixth‐order monotonicity‐preserving scheme by nonlinear spectral analysis

In this paper, sixth‐order monotonicity‐preserving optimized scheme (OMP6) for the numerical solution of conservation laws is developed on the basis of the dispersion and dissipation optimization and monotonicity‐preserving technique. The nonlinear spectral analysis method is developed and is used for the purpose of minimizing the dispersion errors and controlling the dissipation errors. The new scheme (OMP6) is simple in expression and is easy for use in CFD codes. The suitability and accuracy of this new scheme have been tested through a set of one‐dimensional, two‐dimensional, and three‐dimensional tests, including the one‐dimensional Shu–Osher problem, the two‐dimensional double Mach reflection, and the Rayleigh–Taylor instability problem, and the three‐dimensional direct numerical simulation of decaying compressible isotropic turbulence. All numerical tests show that the new scheme has robust shock capturing capability and high resolution for the small‐scale waves due to fewer numerical dispersion and dissipation errors. Moreover, the new scheme has higher computational efficiency than the well‐used WENO schemes. Copyright © 2013 John Wiley & Sons, Ltd.     

Dynamic process of photovoltaic effect in La0.9Sr0.1MnO3/SrNb0.01Ti0.99O3 heterojunction

The dynamic process of photoelectric effects in the La_0.9Sr_0.1MnO₃/SrNb_0.01Ti_0.99O₃ heterostructure is theoretically revealed by solving equations consisting of time dependent drift–diffusion, Richardson thermionic emission current, and Shockley–Read–Hall recombination. The calculated time dependent evolution of photovoltage and the variation of carrier concentration are obtained. Present results indicate that a smaller parallel resistance should result in faster photoelectric response, but reduce the peak value of the photovoltage in a La_0.9Sr_0.1MnO₃/SrNb_0.01Ti_0.99O₃ heterojunction. In addition, the increase of the carrier mobilities induced by applying higher energy photons can decrease the rise time but increase the peak value of the photovoltage.     

A new series of emodin derivatives with bone affinity

A new series of bone affinity compounds were synthesized by linking emodin with 5-fluorouracil derivatives. Their bone affinities were established by hydroxyapative (HA) affinity experiment in vitro, and their cytostatic effects were shown by the MTT assay.     

稀土元素对磷钼钒杂多酸催化氧化活性的影响

讨论了镧的置換度和稀土元素对含氧有机化合物在杂多酸催化剂上的氧化反应的影响,并与催化剂的结构进行了关联。镧的引入不影响氧化脱氢反应,而明显削弱插入氧反应。其它稀土元素的影响与镧相同。     

Determination of the Protein-Protein Interactions within Acyl Carrier Protein (MmcB)-Dependent Modifications in the Biosynthesis of Mitomycin

Mitomycin has a unique chemical structure and contains densely assembled functionalities with extraordinary antitumor activity. The previously proposed mitomycin C biosynthetic pathway has caused great attention to decipher the enzymatic mechanisms for assembling the pharmaceutically unprecedented chemical scaffold. Herein, we focused on the determination of acyl carrier protein (ACP)-dependent modification steps and identification of the protein–protein interactions between MmcB (ACP) with the partners in the early-stage biosynthesis of mitomycin C. Based on the initial genetic manipulation consisting of gene disruption and complementation experiments, genes mitE, mmcB, mitB, and mitF were identified as the essential functional genes in the mitomycin C biosynthesis, respectively. Further integration of biochemical analysis elucidated that MitE catalyzed CoA ligation of 3-amino-5-hydroxy-bezonic acid (AHBA), MmcB-tethered AHBA triggered the biosynthesis of mitomycin C, and both MitB and MitF were MmcB-dependent tailoring enzymes involved in the assembly of mitosane. Aiming at understanding the poorly characterized protein–protein interactions, the in vitro pull-down assay was carried out by monitoring MmcB individually with MitB and MitF. The observed results displayed the clear interactions between MmcB and MitB and MitF. The surface plasmon resonance (SPR) biosensor analysis further confirmed the protein–protein interactions of MmcB with MitB and MitF, respectively. Taken together, the current genetic and biochemical analysis will facilitate the investigations of the unusual enzymatic mechanisms for the structurally unique compound assembly and inspire attempts to modify the chemical scaffold of mitomycin family antibiotics.