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981.
A selective, sequential C–O decarboxylative vinylation/C–H arylation of cyclic alcohol derivatives enabled by visible-light photoredox/nickel dual catalysis is described. This protocol utilizes a multicomponent radical cascade process, i.e. decarboxylative vinylation/1,5-HAT/aryl cross-coupling, to achieve efficient, site-selective dual-functionalization of saturated cyclic hydrocarbons in one single operation. This synergistic protocol provides straightforward access to sp3-enriched scaffolds and an alternative retrosynthetic disconnection to diversely functionalized saturated ring systems from the simple starting materials.

A selective, sequential C–O decarboxylative vinylation/C–H arylation of cyclic alcohol derivatives enabled by visible-light photoredox/nickel dual catalysis has been described.  相似文献   
982.
In this paper, we used bond-length equalization, aromatic stabilization energies (ASE) and nucleus-independent chemical shifts (NICS), calculated with (density functional theory) B3LYP levels at the 6-311+G** basis set, to evaluate the aromaticity of a set of 38 five-member planar π-electron aromatic systems: sila-, aza- and phospha- derivatives and their parent systems. The result revealed statistically significant correlations among the above three criteria, and the order of aromaticity of the whole set was: Aza- derivatives rings > Phospha- derivatives rings > Sila- derivatives rings > Carbon-containing rings; NICS(0.6) and NICS(0.8) had the same results in evaluating the order of aromaticity in our case.  相似文献   
983.
MP2/6-31+G* calculations were performed on the cation- complexes of ethylene, cyclobutadiene and benzene with a number of atomic cations. It was found that except B+ all the atomic cations form -type cation- complexes with ethylene. On the other hand, with cyclobutadiene Li+, N+, Na+, P+ and K+ form -type complexes, whereas H+, F+, and Cl+ form covalent -type complexes. With benzene Li+, B+, Na+, Al+, and K+ form -type complexes whereas H+, F+, and Cl+ form -type complexes. It was concluded that the driving force to form the -type complex is chemical bonding, and that for metal cations to form -type complexes is non-covalent interaction.  相似文献   
984.
Mechanistic studies were conducted on beta-hydrogen elimination from complexes of the general formula [Ir(CO)(PPh(3))(2)(OR)], which are square planar alkoxo complexes with labile ligands. The dependence of rate, isotope effect, and alkoxide racemization on phosphine concentration revealed unusually detailed information on the reaction pathway. The alkoxo complexes were remarkably stable, including those with a variety of electronically and sterically distinct groups at the beta-carbon. These complexes were much more stable than the corresponding alkyl complexes. Thermolysis of these complexes in the presence of PPh(3) yielded the iridium hydride [Ir(CO)(PPh(3))(3)H] and the corresponding aldehyde or ketone with rate constants that were affected little by the groups at the beta-carbon. The reactions were first order in iridium complexes. At low [PPh(3)], the reaction rate was nearly zero order in PPh(3), but reactions at high [PPh(3)] revealed an inverse dependence of reaction rate on PPh(3). The rate constants were similar in toluene, THF, and chlorobenzene. The y-intercept of a 1/k(obs) vs [PPh(3)] plot displayed a primary isotope effect, indicating that the y-intercept did not simply correspond to phosphine dissociation. These data and a dependence of alkoxide racemization on [PPh(3)] showed that the elementary beta-hydrogen elimination step was reversible. A mechanism involving reversible beta-hydrogen elimination followed by associative displacement of the coordinated ketone or aldehyde by PPh(3) was consistent with all of our data. This mechanism stands in contrast with the pathways proposed recently for alkoxide beta-hydrogen elimination involving direct elimination, protic catalysts, or binuclear mechanisms and shows that alkoxide elimination can follow pathways similar to those for beta-hydrogen elimination from alkyl complexes.  相似文献   
985.
IntroductionIn1962,N.V.Kutepow'SgroupfirstusedcomplexesofFe,CoandNiascatalyststocatalyzecarboXylationofethanoltopreparepropanoicacidanditsderivants.Thereactionpressurewashighandtheyieldwaslow.LateronPaulalsandhiscolleagueusedabC13andiodineascatalyst,which…  相似文献   
986.
在PH8.5-9的液中,钙可与DBC-偶氮氯膦形成一种紫色的稳定配合物。该配合物在625nm处有最大吸收,表观摩尔吸光系数为2.6×10~4L.mol~(-1).cm~(-1),配合物组成为Ca:DBC-偶氮氯膦=1:1。在Zn-DTPA和乙二胺的存在下,较大量的Y~(3+)、Fe~(3+)及Cu~(2+)、Mo(Ⅵ)、Cr~(3+)等三十余种离子不干扰钙的测定。方法的选择性较好,利用本方法,并经简单萃取分离基体后,测定了高纯氧化钇和易切削钢中的微量钙,结果令人满意。标准加入试验回收率好。方法简便实用。  相似文献   
987.
某些有机物在氧化物载体表面的自发单层分散   总被引:5,自引:1,他引:5  
自发单层分散原理已在载负型催化剂制备、再生等方面得到越来越广泛的应用[1,2].许多氧化物和盐类可以在载体表面形成单层分散或亚单层分散.有些分散物与载体混合后在低于其熔点的温度下处理,就可以自发分散到载体表面[1,3].这一现象通过XRD、LRS、XPS、SIMS、ISS、EXAFS  相似文献   
988.
Two novel octanortriterpenoids, micranoic acids A (1) and B (2), along with three known compounds, kadsuric acid (3), 3beta-hydroxy-lanost-9(11),24(25)-dien-26-oic acid (4) and schizandronic acid (5), were isolated from the leaves and stems of Schisandra micrantha. The structures of 1 and 2 were determined by 1D and 2D NMR spectroscopic analysis. Micranoic acids A and B represent a new group of triterpenes in which the entire C-17 side chain has lost. This is the first report of octanortriterpenoids isolated from the family Schisandraceae.  相似文献   
989.
Low-valent aluminum Al(i) chemistry has attracted extensive research interest due to its unique chemical and catalytic properties but is limited by its low stability. Herein, a hourglass phosphomolybdate cluster with a metal-center sandwiched by two benzene-like planar subunits and large steric-hindrance is used as a scaffold to stabilize low-valent Al(i) species. Two hybrid structures, (H3O)2(H2bpe)11[AlIII(H2O)2]3{[AlI(P4MoV6O31H6)2]3·7H2O (abbr. Al6{P4Mo6}6) and (H3O)3(H2bpe)3[AlI(P4MoV6O31H7)2]·3.5H2O (abbr. Al{P4Mo6}2) (bpe = trans-1,2-di-(4-pyridyl)-ethylene) were successfully synthesized with Al(i)-sandwiched polyoxoanionic clusters as the first inorganic-ferrocene analogues of a monovalent group 13 element with dual Lewis and Brønsted acid sites. As dual-acid catalysts, these hourglass structures efficiently catalyze a solvent-free four-component domino reaction to synthesize 1,5-benzodiazepines. This work provides a new strategy to stabilize low-valent Al(i) species using a polyoxometalate scaffold.

Monovalent aluminum(i) species was successfully stabilized using a reduced phosphomolybdate scaffold as a dual-acid catalyst for a four-component domino reaction.

Low- or sub-valence aluminum compounds are increasingly growing into a significant frontier subject in coordination and modern organic synthetic chemistry owing to their unique singlet carbene character, Lewis acid/base properties and catalytic reactivity.1 However, low-valence aluminum(i) compounds have inherent electron deficiency and exhibit thermodynamic instability, making them prone to self-polymerization with metal–metal bonds2 or disproportionation3 to metallic Al and Al(iii) species. Inspired by the special stabilizing effect of metallocene compounds, a ligand stabilization strategy has recently been undertaken to stabilize the low-valence aluminum center.4,5 In this regard, the utilized ligand should satisfy two key criteria: (i) sufficient steric hindrance is required to inhibit monomer polymerization; and (ii) a suitable electronic effect is needed to stabilize the aluminum(i) center. A few organometallic Al(i) compounds protected by bulky organic groups have been prepared such as [(Cp*Al)4] (Cp* = C5Me5),6 and [(CMe3)3SiAl4].7 However, despite having the ligand effect, most of these Al(i) compounds still decompose in aqueous solutions or heating conditions. In contrast to organometallic Al(i) compounds, inorganic Al(i) structures, i.e. monomeric monohalides, only exist in gaseous form at high temperature8 and to the best of our knowledge, no stable inorganic Al(i) compound is known at room temperature due to thermodynamic instability. Therefore, exploring efficient strategies to synthesize stable inorganic Al(i) compounds remains highly desired but a great challenge.Polyoxometalates (POMs), a diverse family of inorganic molecular clusters based on early-transition metals (W, Mo, V, Nb, and Ta), have extensively attracted attention in research in various fields of materials science, coordination chemistry, medicinal chemistry and catalysis science.9–11 Owing to their adjustable constituent elements and well-defined structures, POMs have been considered as promising inorganic ligands to stabilize high- and low-valent metal ions. For instance, Rompel et al.12 reported one Keggin-type [α-CrW12O40]5− anion in which a labile {CrIIIO4} tetrahedral unit was assembled at the center of the cluster. Li and co-workers employed a monolacunary Keggin-type inorganic ligand to stabilize a high-valent Cu3+ ion.13 As a unique member of the POM family, the hourglass-type phosphomolybdate cluster {M[P4MoV6O31]2}n (abbr. M{P4Mo6}2), consisting of two [P4MoV6O31]12− (abbr. {P4Mo6}2) subunits bridged by one metal (M) center, represents a fully reduced metal-oxo cluster. With all Mo atoms in the oxidation state of (+5), a more negative charge is endowed to the cluster surface.14,15 Such high electron density of {M[P4MoV6O31]2}n polyoxoanions provides an electron-rich local environment for the possible stabilization of unusual-valence metals. It is worth noting that the [P4MoV6O31]12− subunit presents near-planar triangular structures with the side sizes ranging from 7.50–7.92 Å (Fig. S1). The structural feature can supply sufficient steric hindrance to restrain the polymerization of low-valence metal species. Moreover, the six Mo atoms in each [P4MoV6O31]12− subunit arrange in a planar hexagonal-ring structure like a benzene ring, implying that such {M[P4MoV6O31]2}n clusters may have a similar delocalized electron structure to conjugated benzene or cyclopentadiene. These features make [P4MoV6O31]12− a promising candidate with respect to organic protecting groups to construct an inorganic ‘ferrocene’ analogue of Al(i) (Scheme 1). Therefore, we hypothesize that hourglass-type polyoxoanion clusters are promising to stabilize the labile Al(i) center and isolate inorganic Al(i) species.Open in a separate windowScheme 1Similar ferrocene-like sandwich structure features of an inorganic hourglass-type [AlI(P4MoV6O31)2]23− polyanion to an organometallic [(η5-Cp*)2AlI]+ cation.Herein, we show a [P4MoV6O31]12− cluster as an inorganic scaffold to stabilize the Al(i) center in two hybrid compounds, (H3O)2(H2bpe)11[AlIII(H2O)2]3{[AlI(P4MoV6O31H6)2]3·7H2O (abbr. Al6{P4Mo6}6) and (H3O)3(H2bpe)3[AlI(P4MoV6O31H7)2]·3.5H2O (abbr. Al{P4Mo6}2) (bpe = trans-1,2-di-(4-pyridyl)-ethylene), in which the labile Al(i) center is sandwiched by two [P4MoV6O31]12− sides, forming an inorganic moiety of a ‘ferrocene’ analogue. Both Al6{P4Mo6}6 and Al{P4Mo6}2 are experimentally determined at room temperature for the first time, and prepared by hydrothermal reactions of Na2MoO4·2H2O, H3PO4, AlCl3·6H2O, ethanol and N-containing bpe at 160 °C with slightly different pH values. Notably, the combination of ethanol, N-containing bpe and high hydrothermal temperature is a prerequisite to the isolation of Al(i) species. First, both ethanol and N-containing bpe were used to provide a reducing environment under hydrothermal conditions. By combining high temperature and pressure, sufficient energy is supplied to reduce Mo6+ and Al3+ ions to Mo5+ and Al+ species, respectively. Then, Mo5+ species and phosphoric acid molecules are assembled to form [P4Mo6O31]12− subunits, which are subsequently combined with Al+ ions to form hourglass-type [Al(P4Mo6O31)2]23−, hence effectively stabilizing Al(i) species (Fig. 1). From the perspective of stereochemistry, two highly negative [P4Mo6O31]12− fragments, resembling the methyl cyclopentadiene organic group, sandwich one low-valent metal Al(i) center. Hence, the construction of a strong reducing hourglass-like skeleton makes it possible to stabilize the existing Al+ species.Open in a separate windowFig. 1Ball-and-stick diagram showing the assembly of the hourglass-type cluster {Al(P4Mo6)2}.Single crystal X-ray diffraction revealed the hourglass-type {Al(P4Mo6)2} cluster in Al6{P4Mo6}6 and Al{P4Mo6}2 (Table S1), in which the [P4Mo6O31]12− subunits have a C3 symmetry and display a near-planar structure formed by six edge-sharing {MoO6} octahedra with alternating short Mo–Mo single bonds and long non-bonding Mo⋯Mo contacts. The side sizes of the {P4Mo6} subunit range from 7.50–7.92 Å, which supplies sufficient steric hindrance to restrain the polymerization or disproportionation of low-valence Al(i) species. All Mo atoms are in a reduced oxidation state of +5 and the central Al atoms are in the +1 oxidation state, as confirmed by bond valence calculations (Table S2). Thus, the synthesized Al{P4Mo6}2 represents a fully reduced metal–oxygen cluster. Moreover, the six Mo atoms in each {P4Mo6} subunit present a benzene-like planar hexagonal-ring structure with a similar π-type delocalization electron interaction with Al(i) instead of organic bulky groups. Such π-type delocalization electron interaction constructs an inorganic ‘ferrocene’ analogue of Al(i) and produces sufficient delocalization energy to stabilize Al(i) species. Considering the formation mechanism of traditional metallocenes, {P4Mo6} subunits with a similar strong electron-donating ability and suitable steric-hindrance effect on Cp rings, augment the stability of Al(i) species. Al6{P4Mo6}6 and Al{P4Mo6}2 compounds also present the first isolation of aluminum-sandwiched hourglass-type clusters in POM chemistry. Importantly, regarding the inherent and strong hydrolysis of aluminum species in water, these low-valent Al(i)-containing clusters represent the first example of stable solid-state inorganic sub-valent Al(i) compounds at room temperature.The asymmetric structure of Al6{P4Mo6}6 consists of two crystallographically independent {Al(P4Mo6)2} clusters sandwiched by central Al(1) and Al(4) atoms, two bridging [Al(H2O)2]3+ (Al(2) and Al(3)) cations and six protonated bpe cations (Fig. S2). Aluminum centers involve two kinds of oxidation states: the central Al(1) and Al(4) are in the +1 state, while the bridging Al(2) and Al(3) are in the +3 state. Both Al(1) and Al(4) display the six-coordinated octahedral configuration and bridge two {P4Mo6} subunits to form two {AlI(P4Mo6)2} clusters. The average lengths of Al–O bonds are 2.318–2.324 Å for Al(1) and Al(4) (Table S3), which are slightly longer than those of classic Al–O bonds (1.90 Å) for Al(2) and Al(3), but close to that of the Al–O bond in silica-supported alkylaluminum(i) composites.16–20 The long Al–O lengths for Al(1) and Al(4) centers may be ascribed to the lower electron cloud density located at the surface of the Al(i) cation, resulting in slightly longer bonds with the surrounding oxygen donors.5,21 Moreover, the small distorted extents (sum((dijdave)/dave)2/coordination number) of {Al(1)O6} (3.86 × 10−4) and {Al(4)O6} (1.89 × 10−3) indicate that they are in regular octahedral geometry. Moreover, another structural feature of Al6{P4Mo6}6 is that {AlI(P4Mo6)2} clusters are connected by bridging [Al(H2O)2]3+ cationic fragments (Al(2) and Al(3)), forming an unusual chain-like arrangement (Fig. 2a). It is worth noting that the 1-D chain contains a large repeating monomer with the maximum spacing of 81.69 Å, consisting of twelve Al-containing fragments ({–Al2–Al1–Al3–Al4–Al3–Al1–Al2–Al1–Al3–Al4–Al3–Al1–}). Such a long repeating monomer is rare. Each repeating monomer has two types of symmetric systems: Al(2) in the middle of the monomer plays a center of mirror symmetry and divides the whole repeating monomer into two equidistant half-units of {–Al1–Al3–Al4–Al3–Al1–}; Al(4) in each half-unit further acts as the reverse symmetric center of two {–Al3–Al1–Al2–} subunits. The two types of symmetrical systems form the infinitely extending chain-like structure in Al6{P4Mo6}6. Since bpe is a rigid and conjugated molecular structure, an effective π⋯π stacking interaction emerges and results in a honeycomb-like supramolecular organic moiety, which accommodates these 1-D inorganic chains and stabilizes the whole Al6{P4Mo6}6 framework (Fig. S3 and S4).Open in a separate windowFig. 2(a) One-dimensional (1D) inorganic structure in Al6{P4Mo6}6 with a length of repeating units of 81.69 Å, consisting of twelve Al-containing fragments ({–Al2–Al1–Al3–Al4–Al3–Al1–Al2–Al1–Al3–Al4–Al3–Al1–}). (b) Four kinds of coordination environments of {AlO6} octahedra, respectively (i = 1 − x, y, 0.5 − z; ii = 0.5 − x, 1.5 − y, 1 − z).Al{P4Mo6}2 has a similar structure to Al6{P4Mo6}6 (Table S4), wherein the most obvious difference is that {AlI[P4Mo6]2} clusters exist in isolated form and interact with the surrounding protonated bpe cations via hydrogen bonding to form into a 3-D supramolecular framework (Fig. S5 and S6). The different peripheral environment around the {AlI[P4Mo6]2} cluster can affect its acidity and catalytic activity.The solid-state 27Al NMR spectrum of Al6{P4Mo6}6 depicts two distinct resonances at δ = −22.34 and 27.33 ppm due to the octahedrally coordinated AlIII and AlI sites, respectively (Fig. 3a), indicating two types of Al local environments in Al6{P4Mo6}6. In contrast, Al{P4Mo6}2 displays only one sharp signal at δ = 7.20 ppm due to the octahedrally coordinated AlI sites (Fig. 3b). The observed narrow peak-width corresponds to the highly symmetric charge distribution at the aluminum nucleus, similar to the ferrocene analogue [(η5-Cp*)2AlI]+.5 Noticeably, AlI resonance in Al6{P4Mo6}6 appears at a lower magnetic field compared to Al{P4Mo6}2, due to the different peripheral environment around the hourglass {Al(P4Mo6)2} cluster. XPS spectra of Al6{P4Mo6}6 and Al{P4Mo6}2 further affirm the valence states of Al and Mo elements (Fig. S7 and Table S5). The Al 2p XPS profile of Al6{P4Mo6}6 reveals two peaks at 74.39 and 73.75 eV ascribed to AlIII and AlI, respectively (Fig. 3c). The area ratio of the two peaks is close to 1 : 1, in consistence with the chemical structure of Al6{P4Mo6}6. The high-resolution Al 2p XPS spectrum of Al{P4Mo6}2 displays a weaker broad peak attributed to the low amount of Al+ (Fig. 3d). Moreover, the structural stabilities of Al6{P4Mo6}6 and Al{P4Mo6}2 were investigated by soaking them in water for 24 hours. Fig. S9–S11 show the comparison of XRD, IR and XPS spectra of Al6{P4Mo6}6 and Al{P4Mo6}2 before and after soaking in water. It can be found that the characteristic diffraction peaks in XRD after soaking for 24 hours still show good agreement with the simulated data (Fig. S9). The characterized absorption bands in IR spectra also exhibit good match with the original Al6{P4Mo6}6 and Al{P4Mo6}2 (Fig. S10). The XPS spectra of Al6{P4Mo6}6 after soaking in water were also obtained. There is basically no change in the high-resolution spectra of Al 2p with the AlI/AlIII atomic ratios of ca. 1 : 1 (Fig. S11). The spectroscopic and theoretical observations verify that the low valence Al(i) species can stably exist in the reduced phosphomolybdates in the solid state (Fig. S12 and Table S6). Moreover, the acidities of Al6{P4Mo6}6 and Al{P4Mo6}2 were measured to be 0.27 and 0.442 mmol g−1, respectively, demonstrating the promising potential of Al6{P4Mo6}6 and Al{P4Mo6}2 as dual-acid catalysts.Open in a separate windowFig. 3(a and b) 27Al NMR spectra of solid Al6{P4Mo6}6 and Al{P4Mo6}2; (c and d) XPS spectra of Al in Al6{P4Mo6}6 and Al{P4Mo6}2.The catalytic performance of Al6{P4Mo6}6 and Al{P4Mo6}2 was evaluated via a solvent-free four-component domino reaction for the synthesis of pharmaceutical intermediate 1,5-benzodiazepine (Table 1). With Al6{P4Mo6}6 and Al{P4Mo6}2 as catalysts, the yields of the final product 8aaa reach 83% and 75%, respectively (Table 1, entries 1 and 2). Almost no 8aaa is observed without the acid catalysts, even when the reaction is set for a long time (Table 1, entry 3). This clarifies the excellent catalytic performance of Al6{P4Mo6}6 and Al{P4Mo6}2. Typical Brønsted acid p-TsOH and Lewis acid AlCl3 as control samples yield only 43% and 29% 8aaa, respectively (Table 1, entries 4 and 5), much lower than those attained by Al6{P4Mo6}6 and Al{P4Mo6}2 catalysts. Moreover, (H2en)12[{Na0.8K0.2(H2O)}2{Na[Mo6O12(OH)3(HPO4)2(PO4)2]2}2]·7H2O22,23 (abbr. {Na[P4Mo6]2}) in contrast achieved 72% yield of 8aaa in 30 min, slower than that of Al6{P4Mo6}6 and Al{P4Mo6}2. This indicates the advantage of the unique dual-acid features of Al(i)-stabilized reduced phosphomolybdate clusters with multiple Lewis and Brønsted acid active centers, in which the synergistic effect between the Al species and reduced phosphomolybdate cluster contributes to the catalytic activity.Comparison tests of one-pot synthesis of 1,5-benzodiazepine 8aaavia a four-component domino reactiona
EntryCatalystb t 1 f (h)Yieldc (%) 3a t 2 f (h)Yieldd (%) 5aa T 3 (°C) t 3 f (min)Yielde (%) 8aaa
1 Al6{P4Mo6}6 3.0 98 1.8 92 25 20 83
2Al{P4Mo6}23.2972.089252075
3No catalyst7.0985.56225120Trace
4 p-TsOH4.0923.073252643
5AlCl34.5943.082255829
6{Na[P4Mo6]2}3.5952.586253072
Open in a separate windowaOne-pot reaction conditions: acetophenone 1a (1.00 mmol), N,N-dimethylformamide dimethyl acetal 2 (1.00 mmol), 1,2-phenylenediamine 4a (1.00 mmol), ethyl pyruvate 6a (1.00 mmol) and catalyst (10.00 mg) for the four-component domino reaction.bCatalyst (10.00 mg).cIsolated yield in the first step.dTotal isolated yield for the first two steps.eOverall isolated yield for the 3 steps.fThe time taken for the reaction to complete.Furthermore, the Al6{P4Mo6}6 catalyst displays a wide substrate scope of auto-tandem catalytic reactions. A series of functional groups including carboxyl, ester and acyl groups on the 2-position of the seven-membered rings can be smoothly converted into the desired 1,5-benzodiazepine products with high and even excellent yields (Table S7). 1,2-Phenylenediamines 4 which contain both electron-deficient (p-Cl and p-Br) and electron-rich (p-Me and 3,4-di(Me)) 1,2-phenylenediamines also undergo the reaction smoothly, providing the corresponding products in high yields within the given reaction times (Table S7).Additionally, the Al6{P4Mo6}6 catalyst can be easily recovered by simple filtration. No significant decay in the catalytic activity or selectivity was observed even after 5 recycles of Al6{P4Mo6}6 (Fig. S14). The acquired XRD pattern, and IR and XPS spectra after 5 runs further revealed the good structural integrity and high solid-state stability of Al6{P4Mo6}6 (Fig. S15–S17). Accordingly, the Al6{P4Mo6}6 cluster coupled with dual-acid sites presents great potential application towards the four-component domino reaction.In summary, two cases of low valence Al-centered hourglass-type phosphomolybdates have been reported for the first time. {P4Mo6} subunits with highly negative charge and a benzene-like planar hexagonal-ring structure, display a similar π-type electron interaction with Al(i) to construct inorganic ‘ferrocene’ analogues of Al(i), thus effectively stabilizing Al(i) species. Al(i)-POM structures are confirmed and characterized using 27Al NMR and XPS spectra. When used as acid catalysts, both Al6{P4Mo6}6 and Al{P4Mo6}2 efficiently catalyze a solvent-free domino reaction to synthesize 1,5-benzodiazepines with high yield and selectivity. The Al(i)-stabilized reduced POM structures also exhibit excellent substrate compatibility and cycle stability. The design, synthesis and successful stabilization of the subvalent metallic aluminum compounds in the solid state unravel the significance of this study. This work is also important to develop highly active and multifunctional catalysts for organic reactions.  相似文献   
990.
We report the selection of a new orthogonal aminoacyl tRNA synthetase/tRNA pair for the in vivo incorporation of a photocrosslinker, p-azido-l-phenylalanine, into proteins in response to the amber codon, TAG. The amino acid is incorporated in good yield with high fidelity and can be used to crosslink interacting proteins.  相似文献   
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