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41.
G. T. Jones R. W. L. Jones B. W. Kennedy D. R. O. Morrison M. M. Mobayyen S. Wainstein M. Aderholz D. Hantke E. Hoffmann U. F. Katz J. Kern N. Schmitz W. Wittek H. P. Borner G. Myatt D. Radojicic S. Burke 《Zeitschrift fur Physik C Particles and Fields》1991,51(2):205-208
Using data obtained with the bubble chamber BEBC at CERN, the inclusivef 2 (1270) meson production invp and \(\bar vp\) charged current reactions is studied. It is found thatf 2 production occurs mainly in events with a hadronic invariant massW?7 GeV. In these events, the averagef 2 multiplicity is about half the average ρO multiplicity, and thex F andp T 2 distributions of thef 2 agree in shape with those of the ρO. The predictions of a semi-empirical model (Wells model) are in accord with the measured multiplicities atW>7 GeV, whereas at lowerW the model predicts too largef 2 multiplicities. 相似文献
42.
Elyahu Katz 《Annali di Matematica Pura ed Applicata》1982,130(1):121-129
Summary The chain complex of a twisted free product A*t, FK, is chain homotopy equivalent to a differential graded algebra, which is identified to be a confibration of algebras as defined by Quillen. Under certain connectivity conditions we obtain a long exact sequence connecting the homologies of A, K, and A*t FK. In particular we derive a long exact sequence connecting the homologies of Y, X and (Y Ug CX) (, C, are the loop, the cone and the suspension constructions respectively). A chain complex equivalent to the chain complex of the Milnor free group FX is recognized, from which results a theorem of Bott and Samelson that H(X) is freely generated as a graded algebra by H(X). 相似文献
43.
Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts 总被引:1,自引:0,他引:1
Reeves CD Ward SL Revill WP Suzuki H Marcus M Petrakovsky OV Marquez S Fu H Dong SD Katz L 《Chemistry & biology》2004,11(10):1465-1472
Combinations of the five polyketide synthase (PKS) genes for biosynthesis of tylosin in Streptomyces fradiae (tylG), spiramycin in Streptomyces ambofaciens (srmG), or chalcomycin in Streptomyces bikiniensis (chmG) were expressed in engineered hosts derived from a tylosin-producing strain of S. fradiae. Surprisingly efficient synthesis of compounds predicted from the expressed hybrid PKS was obtained. The post-PKS tailoring enzymes of tylosin biosynthesis acted efficiently on the hybrid intermediates with the exception of TylH-catalyzed hydroxylation of the methyl group at C14, which was efficient if C4 bore a methyl group, but inefficient if a methoxyl was present. Moreover, for some compounds, oxidation of the C6 ethyl side chain to an unprecedented carboxylic acid was observed. By also expressing chmH, a homolog of tylH from the chalcomycin gene cluster, efficient hydroxylation of the 14-methyl group was restored. 相似文献
44.
Jantunen KC Haftbaradaran F Katz MJ Batchelor RJ Schatte G Leznoff DB 《Dalton transactions (Cambridge, England : 2003)》2005,(18):3083-3091
The high-yield synthesis, spectroscopic and structural determination of three new uranium(IV) and thorium(IV)ate complexes supported by three different diamido ether ligands are reported. The reaction of Li2[2,6-iPr2PhN(CH2CH2)]2O (Li2[DIPPNCOCN]) with 1 equiv. of UCl4 in THF generates [DIPPNCOCN]UCl3Li(THF)2(1), while reaction in toluene/ether gives salt-free [DIPPNCOCN]UCl2.1/2C7H8(2), which was identified by paramagnetically shifted 1H NMR. Reaction of 0.5 equiv. of {[tBuNON]UCl2}2([tBuNON]=[(CH3)3CN(Si(CH3)2)]2O2-) with 3.5 equiv. LiI in toluene and a minimal amount of THF results in [tBuNON]UI3Li(THF)2(3) and is very similar in structure to 1. {[MesNON]ThCl3Li(THF)}2(4), a dimeric complex with a Th2Li2Cl6 core, is prepared by reaction of Li2[2,4,6-Me3PhN(Si(CH3)2)]2O (Li2[MesNON]) with ThCl4 in THF. The analogous reaction in toluene did not yield the salt-free complex but rather a sterically crowded diligated compound, [MesNON]2Th (5), which was also structurally characterized. Complex 5 was prepared rationally by reacting 2 equiv. Li2[MesNON] with ThCl4 in toluene. The reaction of 1 and 3 with 2 equiv. of LiCH2Si(CH3)3 generates the stable, salt-free organoactinides [DIPPNCOCN]U(CH2Si(CH3)3)2(6) and [tBuNON]U(CH2Si(CH3)3)2(7). Complex 6 was structurally characterized. These reactions illustrate the viability of ate complexes as useful synthetic precursors. 相似文献
45.
Mild Alkaline Hydrolysis of Aconitine Hydrolysis of aconitine ( 1 ) with 0.04N K2CO3 in 90% MeOH at room temperature yields, besides the alkamine aconine 3 considerable amounts of 8-O-methylaconine ( 6 ) and smaller quantities of desbenzoyl-pyroaconitine ( 4 ) and 16-epi-desbenzoyl-pyroaconitine ( 5 ). Better yields of 4 and 5 are obtained when heating a solution of aconitine in 0.04N K2CO3 in 90% EtOH. 相似文献
46.
A constrained form of the Weber problem is formulated in which no path is permitted to enter a prespecified forbidden region of the plane. Using the calculus of variations the shortest path between two points which does not intersect is determined. If is unconstrained distance, we denote the shortes distance along a feasible path by . The constrained Weber problem is, then: given points and positive weights wj, j = 1,2,…,n, find a point such that is a minimum.An algorithm is formulated for the solution of this problem when is Euclidean distance and is a single circular region. Numerical results are presented. 相似文献
47.
The FT-infrared spectra of two sexithiophenes having their end ,′-positions substituted by n-hexyl or -thiohexyl groups, in neutral and doped states, are studied with the main aim of deriving information about the π-electrons delocalization and about the electronic structure of the charged defects created upon doping with iodine. The analysis of the experimental data is aided by Density Functional Theory calculations. The modifications in the electronic structure of the sexithiophene backbone induced by the n-thiohexyl encapsulation are discussed from the point of view of single molecule interactions in thiol-terminated π-conjugated oligomers bound to metallic or cluster electrodes. 相似文献
48.
Yang Sung Sohn Anat losub-Amir Alfredo E. Cardenas Ola Karmi Merav Darash Yahana Tal Gruman Linda Rowland Henri-Baptiste Marjault Lauren J. Webb Ron Mittler Ron Elber Assaf Friedler Rachel Nechushtai 《Chemical science》2022,13(23):6929
An effective anti-cancer therapy should exclusively target cancer cells and trigger in them a broad spectrum of cell death pathways that will prevent avoidance. Here, we present a new approach in cancer therapy that specifically targets the mitochondria and ER of cancer cells. We developed a peptide derived from the flexible and transmembrane domains of the human protein NAF-1/CISD2. This peptide (NAF-144-67) specifically permeates through the plasma membranes of human epithelial breast cancer cells, abolishes their mitochondria and ER, and triggers cell death with characteristics of apoptosis, ferroptosis and necroptosis. In vivo analysis revealed that the peptide significantly decreases tumor growth in mice carrying xenograft human tumors. Computational simulations of cancer vs. normal cell membranes reveal that the specificity of the peptide to cancer cells is due to its selective recognition of their membrane composition. NAF-144-67 represents a promising anti-cancer lead compound that acts via a unique mechanism.An effective anti-cancer therapy should exclusively target cancer cells and trigger in them a broad spectrum of cell death pathways that will prevent avoidance. 相似文献
49.