全文获取类型
收费全文 | 4139篇 |
免费 | 234篇 |
国内免费 | 16篇 |
专业分类
化学 | 3422篇 |
晶体学 | 16篇 |
力学 | 67篇 |
数学 | 425篇 |
物理学 | 459篇 |
出版年
2023年 | 42篇 |
2022年 | 104篇 |
2021年 | 176篇 |
2020年 | 141篇 |
2019年 | 120篇 |
2018年 | 59篇 |
2017年 | 56篇 |
2016年 | 176篇 |
2015年 | 179篇 |
2014年 | 163篇 |
2013年 | 236篇 |
2012年 | 338篇 |
2011年 | 371篇 |
2010年 | 210篇 |
2009年 | 172篇 |
2008年 | 292篇 |
2007年 | 259篇 |
2006年 | 254篇 |
2005年 | 181篇 |
2004年 | 189篇 |
2003年 | 148篇 |
2002年 | 125篇 |
2001年 | 27篇 |
2000年 | 29篇 |
1999年 | 26篇 |
1998年 | 19篇 |
1997年 | 21篇 |
1996年 | 24篇 |
1995年 | 20篇 |
1994年 | 16篇 |
1993年 | 5篇 |
1991年 | 6篇 |
1990年 | 6篇 |
1989年 | 9篇 |
1988年 | 5篇 |
1987年 | 8篇 |
1986年 | 10篇 |
1985年 | 19篇 |
1984年 | 18篇 |
1983年 | 16篇 |
1982年 | 17篇 |
1981年 | 18篇 |
1980年 | 10篇 |
1979年 | 8篇 |
1978年 | 7篇 |
1977年 | 13篇 |
1976年 | 7篇 |
1975年 | 6篇 |
1974年 | 7篇 |
1973年 | 4篇 |
排序方式: 共有4389条查询结果,搜索用时 15 毫秒
951.
This paper presents a gas chromatography-mass spectrometry (GC-MS) study carried out on human urine to verify whether the administration of glucocorticoids can affect the urinary steroid profile, and especially the levels of endogenous glucocorticoids, androgens and their main metabolites.Betamethasone and beclomethasone, administered either systemically (per os or i.m.) or locally (by inhalation) have been studied. The determination of the urinary levels of endogenous glucocorticoids and androgens was carried out by GC-MS in electron impact ionization mode. Data were evaluated taking into account the baseline individual variability, and compared with values obtained on a control group.Detectable differences were recorded in the steroids metabolites excretion profiles between men and women. The circadian variability of the steroid profile was the same for both sexes, showing a maximum during the morning hours. After systemic treatment with synthetic glucocorticoids, the relative urinary concentrations of corticosteroids, androgens and of their metabolites were significantly altered, recording a transient decrease of the concentration of cortisol and tetrahydrocortisol and a parallel, although less pronounced, increase of the concentration of testosterone, epitestosterone and related androgenic steroids; while no effects were recorded if the administration was by inhalation. 相似文献
952.
Glassy carbon electrodes modified with coatings of poly-[1-methyl-3-(pyrrol-1-ylmethyl)pyridinium], poly-MPP, were employed for preconcentrating and detecting the anionic complex HgCl4(2-), which is the prevailing inorganic Hg(II) species in salt waters such as the pore-waters of sediments here examined. The application of ion-exchange voltammetry at poly-MPP coated electrodes in combination with an in situ pore-water sampler allowed the measurement of concentration vs. depth profiles for mercury dissolved in the pore-waters of a salt-marsh and of a mud-flat located in a polluted area of the Venice Lagoon. The trends of the mercury profiles are discussed in comparison with the trends measured from the same location for other trace metals (Zn, Cd, Cu and Pb) and reduced species such as S(-II) and Fe(II). 相似文献
953.
Molecular orbitals were determined for an analogue of reduced rubredoxin in an iterative extended Hückel (self-consistent charge) calculation. Zero field splittings and Mössbauer spectral parameters were then computed. The results are compared with available experimental data. 相似文献
954.
A method utilizing solvent extraction and analysis by gas chromatography-positive chemical ionization mass spectrometry (SE-GC-PCIMS) was developed for the analysis of three neutral hydrophobic perfluorooctanesulfonamide compounds [perfluorooctanesulfonamide (PFOSA), N-ethyl perfluorooctanesulfonamide (N-EtPFOSA), and N,N-diethyl perfluorooctanesulfonamide (N,N-Et2PFOSA)]. These compounds are suspected metabolic precursors of perfluorooctane sulfonate. The SE-GC-PCI-MS method was used to analyze all three perfluorooctanesulfonamides in fast food, fish, and Arctic marine mammal liver samples. The SE-GC-PCI-MS method produced relatively higher recoveries of the analytes (averaging 83 +/- 6%, 84 +/- 9%, and 89 +/- 19% for N,N-Et2PFOSA, N-EtPFOSA, and PFOSA, respectively) with lower coefficients of variation, and less susceptibility to matrix effects, than ion pair extraction-liquid chromatography-tandem mass spectrometric methods. Method detection limits (MDLs) were 100, 120, and 250 pg/g for N,N-Et2PFOSA, N-EtPFOSA, and PFOSA, respectively. The three compounds were found at concentrations ranging from below the MDL to 22 ng/g wet weight in fast food, fish, and Arctic marine mammal liver samples. 相似文献
955.
The chemical reactions of hypofluorous acid with aromatic and olefinic substrates show considerable variety. Hypofluorous acid reacts with naphthalene to give 1-naphthol, 2-naphthol and 1,4-naphtho-quinone; with benzo[b]thiophen to give the 1,1-dioxide; with trans-stilbene to give threo-2-fluoro-1-hydroxy-1, 2-diphenylethane, benzophenone and diphenylacetaldehyde; and with cholesteryl acetate to give the two epoxides (α:β = 6.3:1) and two fluorohydrins (6β-fluoro-5β-o1 and 5α-fluoro-6β-o1). 相似文献
956.
Laura Sereni 《Tetrahedron》2004,60(38):8561-8577
6-Acylmino-1-alkyl/aryl-4-oxo-1,4-dihydrocinnoline-3-carboxamides were synthesized in parallel from 6-nitro-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid. The latter formed amides with amines bound to polystyrene-based resins via acid-labile linkers. N1 and N2-alkylation, followed by alkyl migration yielded only N1-alkylated products. Reduction of the 6-nitro group and acylation concluded the synthesis. 相似文献
957.
Laura Fernández‐Llano M. Carmen Blanco‐López M. Jesús Lobo‐Castañón Arturo J. Miranda‐Ordieres Paulino Tuñón‐Blanco 《Electroanalysis》2007,19(15):1555-1561
A molecularly imprinted polymer for diclofenac (DCF) was prepared by thermal polymerization over silica beads using 2‐(dimethylamino)ethyl‐methacrylate as functional monomer. After silica elimination by HF treatment, the polymer was applied to the selective solid‐phase extraction of the drug from urine followed by its quantification by adsorptive differential pulse voltammetry. Results indicate that the drug could be selectively extracted from the sample and quantified at clinically relevant concentrations (μg/mL). 相似文献
958.
Edoardo Cesarotti Maria Grassi Laura Prati
Francesco Demartin
《Journal of organometallic chemistry》1989,370(1-3):407-419The DANTE technique and NOESY two-dimensional method have been employed to observe the isomerization of the chiral cationic complex [Pd(η3-CH2CMeCH2(P-P′)]+ (1a), where P-P′ = the chiral chelating ligand (S)(N-diphenylphosphino)(2-diphenylphosphinoxymethyl)pyrrolidine. The rate constant was found to be 0.5 s−1 in CHCl3 at 295 K and 1.50 s−1 in the presence of added free ligand. In the latter case the epimerization proceeds by a π-σ-π mechanism via the intermediacy of a primary η1-allylpalladium complex. Although the intermediate was not detected, the NMR findings reveal that it has the allylic terminus η1-bonded to palladium. The structure of 1a in its PF6− salt has been determined. The compound crystallizes in the orthorhombic space group P212121 with a 10.029(4) b 19.203(8) c 36.115(6) Å, Z = 8, R = 0.0572 and Rw = 0.0712 for 3716 observed reflections with I > 3σ(I). 相似文献
959.
Alunni S Del Giacco T De Maria P Fontana A Gasbarri C Ottavi L 《The Journal of organic chemistry》2004,69(18):6121-6123
Second-order rate constants have been determined for the title reactions in OH(-)/H(2)O and in OH(-)/ (CH(3)CN/H(2)O) [30/70, 60/40, and 85/15 (v/v) mixtures]. A relatively small increase in reactivity is observed for the four substrates upon increasing the percentage of CH(3)CN in the solvent mixture. The methyl activating factors (/) are also slightly affected by the solvent composition. On the other hand, the high acceleration of the reaction by methylation of the pyridine ring amounts to 10(4)-10(6) according to an E1cb mechanism. 相似文献
960.
Rosaria Villano Maria Rosaria Acocella Antonio Massa Laura Palombi Arrigo Scettri 《Tetrahedron: Asymmetry》2006,17(24):3332-3334
Chiral δ-hydroxy-β-ketoesters are easily available through the enantioselective vinylogous aldol reaction of Chan’s diene promoted by a SiCl4/chiral phosphoramide catalytic system. The procedure is conveniently exploited for a very rapid approach to (+)-kavain, a natural bio-active -pyrone compound. 相似文献