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Moringa oleifera (M. oleifera), which belongs to the Moringaceae family, is a common herb, rich in plant compounds. It has a variety of bioactive compounds that can act as antioxidants, antibiotics, anti-inflammatory and anti-cancer agents, etc., which can be obtained in different body parts of M. oleifera. Isothiocyanates (ITCs) from M. oleifera are one class of these active substances that can inhibit cancer proliferation and promote cancer cell apoptosis through multiple signaling pathways, thus curbing cancer migration and metastasis, at the same time they have little adverse effect on normal cells. There are multiple variants of ITCs in M. oleifera, but the predominant phytochemical is 4-(α-L-rhamnosyloxy)benzyl isothiocyanate, also known as moringa isothiocyanate (MIC-1). Studies have shown that MIC-1 has the possibility to be used clinically for the treatment of diabetes, neurologic diseases, obesity, ulcerative colitis, and several cancer types. In this review, we focus on the molecular mechanisms underlying the anti-cancer and anti-chronic disease effects of MIC-1, current trends, and future direction of MIC-1 based treatment strategies. This review combines the relevant literature of the past 10 years, in order to provide more comprehensive information of MIC-1 and to fully exploit its potentiality in the clinical settings. 相似文献
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The synthesis of 3,5-substituted 1,2,4-oxadiazoles on solid support is described. Benzoic acids bound to the Wang linker on a polystyrene resin are activated and allowed to react with N-hydroxyamidines. The resulting acylated N-hydroxyamidines are converted into 1,2,4-oxadiazoles at 125°C. 相似文献
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The nonlinear Raman methods IRS and CARS are compared according to the signal detectability at excitation of molecules under the condition of one-photon resonance. At one photon resonance it is the background contribution resulting from the scattering molecules themselves that determines the maximum attainable signal to noise ratio. These contributions acting for IRS and CARS respectively are compared. The essential difference between IRS and CARS results from a 3rd order saturation contribution to IRS, which may mask the IRS Raman signal near exact resonance while it does not contribute to CARS. This gives to CARS the preference before IRS at resonance excitation. The situation for IRS with respect to background is similar to that of spontaneous Raman scattering, where the resonance fluorescence — corresponding to the saturation contribution at IRS — masks the resonance Raman signal. 相似文献
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