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931.
The synthesis of 3,5-substituted 1,2,4-oxadiazoles on solid support is described. Benzoic acids bound to the Wang linker on a polystyrene resin are activated and allowed to react with N-hydroxyamidines. The resulting acylated N-hydroxyamidines are converted into 1,2,4-oxadiazoles at 125°C. 相似文献
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Moringa oleifera (M. oleifera), which belongs to the Moringaceae family, is a common herb, rich in plant compounds. It has a variety of bioactive compounds that can act as antioxidants, antibiotics, anti-inflammatory and anti-cancer agents, etc., which can be obtained in different body parts of M. oleifera. Isothiocyanates (ITCs) from M. oleifera are one class of these active substances that can inhibit cancer proliferation and promote cancer cell apoptosis through multiple signaling pathways, thus curbing cancer migration and metastasis, at the same time they have little adverse effect on normal cells. There are multiple variants of ITCs in M. oleifera, but the predominant phytochemical is 4-(α-L-rhamnosyloxy)benzyl isothiocyanate, also known as moringa isothiocyanate (MIC-1). Studies have shown that MIC-1 has the possibility to be used clinically for the treatment of diabetes, neurologic diseases, obesity, ulcerative colitis, and several cancer types. In this review, we focus on the molecular mechanisms underlying the anti-cancer and anti-chronic disease effects of MIC-1, current trends, and future direction of MIC-1 based treatment strategies. This review combines the relevant literature of the past 10 years, in order to provide more comprehensive information of MIC-1 and to fully exploit its potentiality in the clinical settings. 相似文献
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Chinese word recognition (CWR) test was conducted by grades 3 and 5 children under the different conditions of reverberation time (RT), background noise level (BNL) and speech sound pressure level (SSPL) in three primary-school classrooms. The CWR scores and signal to noise ratios (SNRs) have been obtained at listening positions. Results show that the CWR score for grades 3 and 5 children increases with increase of SSPL, decrease of RT or increase of age, but it decreases with increase of BNL under the same conditions. For a mixed noise of 56 dBA (speech-spectrum-like noise and ambient noise), the CWR scores in the classroom for grades 3 and 5 children reach a peak at SNR of 15–20 dBA under the same RT and age of children condition. For the natural ambient noise, the CWR score for grades 3 and 5 children gradually increases with increase of the SNR. The high SSPL could not guarantee good CWR for children in classroom, which also depends on RT and BNL in classroom. When the classroom has long RT or high BNL, the increase of SSPL would not be necessarily to achieve better CWR. The novelty of the present study is to further evaluate and confirm the results under environments of real classrooms (not simulated room in laboratory). 相似文献
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