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排序方式: 共有141条查询结果,搜索用时 15 毫秒
71.
Gerardo Cebrián-Torrejón Landry Kablan Maria Elena Ferreira David Rodríguez de la Cruz Antonio Doménech-Carbó Ninfa Vera de Bilbao 《Natural product research》2015,29(21):2054-2058
This article is focused on the seasonal variation in the contents of 5-methoxycanthin-6-one from the leaves of Zanthoxylum chiloperone (Rutaceae). Based on the pharmacological interest presented by 5-methoxycanthin-6-one, its seasonal variation in Z. chiloperone leaves was analysed in order to determine the best time for harvesting, optimising the 5-methoxycanthin-6-one content. The seasonal dynamics of canthinone alkaloids can be the key to improve the isolation from natural sustainable sources, such as leaves. Complementarily, this study describes the phytochemistry of leaf from this Ruraceae species. 相似文献
72.
Linear nickel nitrosyl compounds supported by tridentate nitrogen and selenium ligands, namely the tris(3,5-dimethylpyrazolyl)hydroborato and tris(2-seleno-1-mesitylimidazolyl)hydroborato complexes, [TpMe2]NiNO and [TseMes]NiNO, have been synthesized and structurally characterized by X-ray diffraction. Computational studies demonstrate that the linear nitrosyl ligand behaves as a trivalent X3 ligand such that the Ni-N interaction has multiple bond character. 相似文献
73.
The spontaneous hydrolysis of the methyl-ester group of cocaine ( 1 ) in vivo contributes to the metabolic clearance of the drug in man. Neighboring-group participation by the tropane N-atom of cocaine in this hydrolysis was suggested by the normal stability of the methyl-ester groups of pseudococaine and N-acylnorcocaine. For cocaine, the relative rate of methyl-ester to benzoyl-ester hydrolysis was ca. 10:1 at pH≤7.4, and, although absolute rates increased with increasing pH, their ratio collapsed at pH>pKa (8.6). These data are consistent with intramolecular acid catalysis of alkaline hydrolysis of the cocaine methyl-ester group under physiologic conditions. 相似文献
74.
Solidification/stabilization of lead with the aid of bagasse as an additive to Portland cement 总被引:1,自引:0,他引:1
Michael A. Janusa Chet A. Champagne Joseph C. Fanguy Grant E. Heard Patrick L. Laine April A. Landry 《Microchemical Journal》2000,65(3)
Solidification/stabilization (S/S) of hazardous waste is a widely used technology; therefore, it is crucial to evaluate its effectiveness and make attempts to improve the technique. A better matrix for S/S of hazardous waste was designed that is effective and economically feasible. This was accomplished by adding bagasse (byproduct of milling or diffusing sugar cane) to the waste/cement matrix. Lead nitrate was used as the model heavy metal waste with a 10 or 15% lead by weight to cement loading. Samples were cured for 7, 14, and 28 days at 24°C. Samples containing bagasse typically resulted in TCLP (modified) extract lead concentrations of approximately 0.5 mg/l of lead for all samples, while samples containing no bagasse had lead extract concentrations of approximately 5 mg/l for 10% samples and 45 mg/l for 15%. Results indicate that using bagasse as an additive to cement effectively improved the S/S of lead. 相似文献
75.
J.E. Macías-Díaz F.J. Avelar-González R.S. Landry 《Journal of Difference Equations and Applications》2013,19(11):1021-1043
In this work, we propose an efficient implementation of a finite-difference method employed to approximate the solutions of a system of partial differential equations that appears in the investigation of the growth of biological films. The associated homogeneous Dirichlet problem is discretized using a linear approach. This discretization yields a positivity- and boundedness-preserving implicit technique which is represented in vector form through the multiplication by a sparse matrix. A straightforward implementation of this methodology would require a substantial amount of computer memory and time, but the problem is conveniently coded using a continual reduction of the zero sub-matrices of the representing matrix. In addition to the conditions that guarantee the positivity and the boundedness of the numerical approximations, we establish some parametric constraints that assure that the same properties for the discrete total mass at each point of the mesh-grid and each discrete time are actually satisfied. Some simulations are provided in order to illustrate both the performance of the implementation, and the preservation of the positivity and the boundedness of the numerical approximations. 相似文献
76.
A simplistic convenient “arm‐first” catalytic synthesis method is demonstrated to render soft unimolecular star polyethylene nanoparticles. Low‐dispersity polyethylene arms of controllable length and topology are first synthesized via Pd‐catalyzed “living” ethylene polymerization. The subsequent addition of norbornadiene as a unique cross‐linker renders the block polymer containing a short polynorbornadiene (PNBD) sequence. Efficient and rapid catalytic cross‐linking of the PNBD sequences occurs in the polymer precipitation and drying steps to give rise to star polyethylene nanoparticles. The star polymers are featured with tunable arm length and topology, high molecular weight (as high as 1770 kg mol−1), high arm numbers (as high as 88), and desirable average nanoparticle size (29−72 nm).
77.
Duncan AK Klemm PJ Raymond KN Landry CC 《Journal of the American Chemical Society》2012,134(19):8046-8049
Particle-based magnetic resonance imaging (MRI) contrast agents have been the focus of recent studies, primarily due to the possibility of preparing multimodal particles capable of simultaneously targeting, imaging, and treating specific biological tissues in vivo. In addition, particle-based MRI contrast agents often have greater sensitivity than commercially available, soluble agents due to decreased molecular tumbling rates following surface immobilization, leading to increased relaxivities. Mesoporous silica particles are particularly attractive substrates due to their large internal surface areas. In this study, we immobilized a unique phosphonate-containing ligand onto mesoporous silica particles with a range of pore diameters, pore volumes, and surface areas, and Gd(III) ions were then chelated to the particles. Per-Gd(III) ionic relaxivities ranged from ~2 to 10 mM(-1) s(-1) (37 °C, 60 MHz), compared to 3.0-3.5 mM(-1) s(-1) for commercial agents. The large surface areas allowed many Gd(III) ions to be chelated, leading to per-particle relaxivities of 3.3 × 10(7) mM(-1) s(-1), which is the largest value measured for a biologically suitable particle. 相似文献
78.
79.
Vidović D Xie Y Rinderspacher A Deng SX Landry DW Chung C Smith DH Tautz L Schürer SC 《Journal of computer-aided molecular design》2011,25(9):873-883
The lymphoid tyrosine phosphatase (LYP), encoded by the PTPN22 gene, has recently been identified as a promising drug target
for human autoimmunity diseases. Like the majority of protein-tyrosine phosphatases LYP can adopt two functionally distinct
forms determined by the conformation of the WPD-loop. The WPD-loop plays an important role in the catalytic dephosphorylation
by protein-tyrosine phosphatases. Here we investigate the binding modes of two chemotypes of small molecule LYP inhibitors
with respect to both protein conformations using computational modeling. To evaluate binding in the active form, we built
a LYP protein structure model of high quality. Our results suggest that the two different compound classes investigated, bind
to different conformations of the LYP phosphatase domain. Binding to the closed form is facilitated by an interaction with
Asp195 in the WPD-loop, presumably stabilizing the active conformation. The analysis presented here is relevant for the design
of inhibitors that specifically target either the closed or the open conformation of LYP in order to achieve better selectivity
over phosphatases with similar binding sites. 相似文献
80.
We demonstrate an effective method for generating libraries of encoded compounds for fabricating large compound microarrays on solid supports. This method is based on one-bead, one-compound synthesis and employs a novel trilayer bead-partition scheme that ensures sufficient quantity of synthesized compounds releasable from each bead for compound microarray fabrication in high-throughput protein–ligand discovery assays.
[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.] 相似文献