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81.
Tesarova H Svobodova B Kokoska L Marsik P Pribylova M Landa P Vadlejch J 《Natural product communications》2011,6(2):213-216
In this study, the antioxidant capacities of main quinone constituents of Nigella sativa seeds, namely dithymoquinone (1), thymohydroquinone (2) and thymoquinone (3), were compared using DPPH and ORAC methods. The best scavenging activity was produced by 2, which showed a remarkable activity of 2.60 Trolox equivalents (TE) in a concentration range between 1.6 and 6.4 microg/mL and IC50 value of 2.4 microg/mL in ORAC and DPPH assays, respectively. Contrastingly, 3 possessed only weak DPPH scavenging efficacy (IC50 = 170 microg/mL) but significant antioxidative action of 1.91 TE in ORAC assay. No effect has been observed for 1. Additionally, modified protocol for synthesis of 2 has been developed with aim to enhance its availability for further studies as well as for its future potential use. Based on the results of this study, we conclude that 2 could be considered as a compound with prospective antioxidative properties. 相似文献
82.
Purushottam Kumar Aniruddh Khanna Seung-Young Son Jae Seok Lee Rajiv K. Singh 《Optics Communications》2011,284(19):4279-4282
Microlens array has been known to be effective in enhancing the out coupling efficiency of LEDs, OLEDs and other thin film light emitting devices. However, mechanism of efficiency enhancement by use of microlens arrays is still ambiguous, apart from suggestions that it leads to randomization of photons. We have studied the photon dynamics in the presence of microlens arrays and the effect of various parameters e.g. microlens contact angle, absorption and substrate refractive index using ray tracing simulations. Microlens array leads to extraction of a portion of photons outside the escape cone at the cost of reduced extraction from within the escape cone. The reduced extraction from within the escape cone is compensated by multiple reflections from the back surface. Increase in microlens contact angle reduces the number of reflections required for out-coupling hence reducing the absorption in the device. 相似文献
83.
Purushottam Kumar Seung Young Son Kannan Balasundaram Rajiv Singh 《Optics Communications》2011,284(20):4874-4878
Regular periodic textures e.g., microlens arrays, micro-pyramids, and cones on substrate surface have been used to enhance light out-coupling in light emitting devices. Photon randomization, often associated with surface roughening, has been suggested as the mechanism for out-coupling enhancement. This article analytically investigates the ray dynamics in a light emitting device when periodic texture is used as an external out-coupler. An attempt has been made to understand the relationship between enhancement in out-coupling and the surface inclination of these structures using classical ray optics. 相似文献
84.
June Izquierdo Noémie Demurget Dr. Aitor Landa Prof. Tore Brinck Prof. Jose M. Mercero Prof. Peter Dinér Prof. Mikel Oiarbide Prof. Claudio Palomo 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(53):12431-12438
A bifunctional amine/squaramide catalyst promoted direct aldol addition of an hydantoin surrogate to pyridine 2-carbaldehyde N-oxides to afford adducts bearing two vicinal tertiary/quaternary carbons in high diastereo- and enantioselectivity (d.r. up to >20:1; ee up to 98 %) is reported. Acid hydrolysis of adducts followed by reduction of the N-oxide group yields enantiopure carbinol-tethered quaternary hydantoin-azaarene conjugates with densely functionalized skeletons. DFT studies of the potential energy surface (B3LYP/6–31+G(d)+CPCM (dichloromethane)) of the reaction correlate the activity of different catalysts and support an intramolecular hydrogen-bond-assisted activation of the squaramide moiety in the transition state of the catalytic reaction. 相似文献
85.
Sensitive method for the determination of rocilinostat in small volume mouse plasma by LC‐MS/MS and its application to a pharmacokinetic study in mice 下载免费PDF全文
Manish Gupta Abhishek Dixit V. C. Devaraj Mohd Zainuddin Ravi Kanth Bhamidipati Mahanandeesha S. Hallur Purushottam Dewang Sridharan Rajagopal Sriram Rajagopal Ramesh Mullangi 《Biomedical chromatography : BMC》2016,30(7):1138-1144
A highly sensitive, specific and rapid LC‐ESI‐MS/MS method has been developed and validated for the quantification of rocilinostat in small volume mouse plasma (20 μL) using vorinostat as an internal standard (IS) as per regulatory guidelines. Sample preparation was accomplished through a protein precipitation procedure with acetonitrile. Chromatography was achieved on Prodigy ODS‐2 column using a binary gradient using mobile phase A (0.2% formic acid in water) and B (acetonitrile) at a flow rate of 0.38 mL/min. The total chromatographic run time was 4.1 min and the elution of rocilinostat and IS occurred at ~3.2 and 2.9 min, respectively. A linear response function was established in the concentration range of 0.28–1193 ng/mL in mouse plasma. The intra‐ and inter‐day accuracy and precisions were in the ranges of 3.12–8.93 and 6.41–11.6%, respectively. This novel method has been applied to a pharmacokinetic study in mice. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
86.
Landa A Minkkilä A Blay G Jørgensen KA 《Chemistry (Weinheim an der Bergstrasse, Germany)》2006,12(13):3472-3483
A new, short, and simplified procedure for the synthesis of optically active pyridine derivatives from pro-chiral pyridine-N-oxides is presented. The catalytic and asymmetric Mukaiyama aldol reaction between ketene silyl acetals and 1-oxypyridine-2-carbaldehyde derivatives catalyzed by chiral copper(II)-bis(oxazoline) complexes gave optically active 2-(hydroxyalkyl)- and 2-(anti-1,2-dihydroxyalkyl)pyridine derivatives in good yields and diastereoselectivities, and in excellent enantioselectivities-up to 99 % enantiomeric excess. As a synthetic application of the developed method, a full account for the asymmetric total synthesis of a nonnatural indolizine alkaloid is provided. 相似文献
87.
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89.
Jegorov A Paizs B Kuzma M Zabka M Landa Z Sulc M Barrow MP Havlicek V 《Journal of mass spectrometry : JMS》2004,39(8):949-960
Profiling of cyclic tetradepsipeptides beauverolides was tested as a chemotaxonomic tool for fungal strain identification/discrimination. Two new tetradepsipeptides, beauverolides Q and R, were characterized by tandem mass spectrometry. Specific elimination of 113 atomic mass units from both protonated and sodiated molecules of beauverolides is ubiquitous for all 12 most dominant congeners evaluated in this profiling study. Reconstruction of the total ion chromatogram, according to this neutral fragment release, was used for data filtering and selectivity enhancement. Selective ring opening and fragment ion formation of beauverolide I are discussed in detail utilizing high-level theoretical modeling of the fragmentation pathways. 相似文献
90.