全文获取类型
收费全文 | 463篇 |
免费 | 12篇 |
国内免费 | 4篇 |
专业分类
化学 | 324篇 |
晶体学 | 1篇 |
力学 | 12篇 |
数学 | 35篇 |
物理学 | 107篇 |
出版年
2022年 | 4篇 |
2021年 | 8篇 |
2020年 | 8篇 |
2019年 | 6篇 |
2018年 | 7篇 |
2017年 | 4篇 |
2016年 | 11篇 |
2015年 | 12篇 |
2014年 | 8篇 |
2013年 | 22篇 |
2012年 | 18篇 |
2011年 | 32篇 |
2010年 | 19篇 |
2009年 | 20篇 |
2008年 | 35篇 |
2007年 | 21篇 |
2006年 | 25篇 |
2005年 | 14篇 |
2004年 | 16篇 |
2003年 | 15篇 |
2002年 | 11篇 |
2001年 | 10篇 |
2000年 | 3篇 |
1999年 | 5篇 |
1997年 | 5篇 |
1996年 | 5篇 |
1995年 | 9篇 |
1994年 | 7篇 |
1993年 | 9篇 |
1992年 | 13篇 |
1991年 | 8篇 |
1990年 | 4篇 |
1989年 | 7篇 |
1988年 | 6篇 |
1987年 | 7篇 |
1986年 | 3篇 |
1985年 | 4篇 |
1984年 | 5篇 |
1983年 | 2篇 |
1982年 | 6篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1979年 | 4篇 |
1977年 | 5篇 |
1976年 | 4篇 |
1975年 | 10篇 |
1974年 | 2篇 |
1973年 | 5篇 |
1971年 | 3篇 |
1968年 | 3篇 |
排序方式: 共有479条查询结果,搜索用时 15 毫秒
471.
Hue T. B. Bui Duy D. Vo Yen N. T. Chau Cuc T. K. Tu Hieu V. Mai Kiet V. Truong 《合成通讯》2013,43(24):2861-2868
A facile synthetic method for the construction of 2-substituted-4-oxo-4H-quinolizine-based core structure has been successfully developed. The synthesis made use of a one-pot Stobbe condensation followed by cyclization starting from the commercially available 2-pyridinecarbaldehyde. The structure of the formed 4-oxo-4H-quinolizine-2-carboxylate was fully confirmed by mass spectra, 1H NMR and 13C NMR, correlation spectrography, heteronuclear multiple bond correlation, and heteronuclear single quantum coherence (HSQC) spectra. The ethyl carboxylate moiety was then further functionalized via direct aminolysis by a range of amines to afford the corresponding 4-oxo-4H-quinolizine-2-carboxamides 4a–i in moderate to good yields. 相似文献
472.
Vu TB Kalkman I Meerts WL Svartsov YN Jacoby C Schmitt M 《The Journal of chemical physics》2008,128(21):214311
The rotationally resolved electronic spectra of the electronic origin of the 7-azaindole-(H(2)O)(1) and of the 7-azaindole-(H(2)O)(2) clusters have been measured in a molecular beam. From the rotational constants the structures in the S(0) and S(1) electronic states were determined as cyclic with the pyrrolo NH and the pyridino N atoms being bridged by one and two water molecules, respectively. Excited state lifetimes of about 10 ns for both clusters have been found. In the spectrum of the 7-azaindole-(H(2)O)(2) cluster a splitting of the rovibronic band is observed, which can be traced back to a large amplitude motion, involving the out-of-plane hydrogen atoms of the water chain. Both the changes of the rotational constants upon electronic excitation and the orientation of the transition dipole point to a solvent induced state reversal between the L(a) and the L(b) states upon microsolvation. 相似文献
473.
We present a simple method based on the Cu2+ induced unfolding of G‐quadruplex (G4) of human telomere sequence d[AG3(T2AG3)3] to screen a number of 3,6‐bis(1‐methyl‐4‐vinylpyridinium)carbazole diiodide (BMVC) analogues for better G4 stabilizers. Using circular dichroism (CD), the screening results suggest that the tri‐cations of 9‐substituted BMVC derivatives are better G4 stabilizers than the bi‐cations of BMVC. In addition, 3,6‐bis(1‐methyl‐4‐vinylpyrazinium)carbazole diiodide (BMVC4) is likely a better core molecule than BMVC for G4 stabilizers. 相似文献
474.
Nguyen XN Phan VK Chau VM Bui HT Nguyen XC Vu KT Hoang le TA Jo SH Jang HD Kwon YI Kim YH 《Chemical & pharmaceutical bulletin》2010,58(10):1408-1410
One new monoterpenoid glycoside, myresculoside (1), and eleven known compounds, were isolated from methanol extract of Myrica esculenta leaves by repeated column chromatography. The effects of these compounds on angiotensin I-converting enzyme (ACE) inhibition were investigated. Compounds 3 and 4 showed the most potent ACE inhibition with rates of 29.97% and 25.63% at concentration of 100 μM, respectively. Compounds 5, 6, and 11 showed weak activity with inhibitory rates of 0.07-1.41% at concentration of 100 μM. 相似文献
475.
Development of chromatographic fingerprint (CF) and related chemometric methods and their applications to quality control of traditional Chinese medicines (TCMs) were discussed. CF is essentially a kind of quality control method for TCMs (or Chinese herbal medicines). Also, it is a quality‐relevant‐data high‐throughput and integral tool to explore chemically the complexity of TCMs. With the help of chemometrics, some difficulties in evaluation and analysis of CFs, such as calculation of information content, peak alignment, pattern analysis, deconvolution of overlapping peaks, etc. could be well solved. To further explore TCMs synergic quality, intensive study of CF coupled with chemometrics will create the possibility to achieve the aim to reveal the working mechanisms of TCMs and to further control and strengthen TCMs' intrinsic quality in a comprehensive manner. 相似文献
476.
Yuye He Chin Yee Liew Nitin Sharma Sze Kwang Woo Yi Ting Chau Chun Wei Yap 《Journal of computational chemistry》2013,34(7):604-610
ADMET (absorption, distribution, metabolism, excretion, and toxicity)‐related failure of drug candidates is a major issue for the pharmaceutical industry today. Prediction of PD‐PK‐T properties using in silico tools has become very important in pharmaceutical research to reduce cost and enhance efficiency. PaDEL‐DDPredictor is an in silico tool for rapid prediction of PD‐PK‐T properties of compounds from their chemical structures. It is free and open‐source software that, has both graphical user interface and command line interface, can work on all major platforms (Windows, Linux, and MacOS) and supports more than 90 different molecular file formats. The software can be downloaded from http://padel.nus.edu.sg/software/padelddpredictor . © 2012 Wiley Periodicals, Inc. 相似文献
477.
Two analogous multipolar chromophores ( 1 and 2 ) that contained 2,3,8‐trisubstituted indenoquinoxaline moieties have been synthesized and characterized for their two‐photon absorption properties, both in the femtosecond and nanosecond time regimes. We demonstrated that their multi‐branched framework structures, which incorporated appropriately functionalized indenoquinoxaline units, afforded large molecular nonlinear absorptivities within the studied spectroscopic range. Effective optical‐power‐limiting and stabilization behaviors in the nanosecond regime of dye molecule ( 2 ) were also investigated and the results indicated that such a structural motif could be a useful approach to the molecular design of highly active two‐photon systems for quick‐response and related broadband optical‐suppressing applications, in particular for confronting laser pulses of a long duration. 相似文献
478.
Jingqin Chen Adam C. Sedgwick Sajal Sen Yaguang Ren Qinchao Sun Calvin Chau Jonathan F. Arambula Tridib Sarma Liang Song Jonathan L. Sessler Chengbo Liu 《Chemical science》2021,12(29):9916
Photoacoustic imaging (PAI) relies on the use of contrast agents with high molar absorptivity in the NIR-I/NIR-II region. Expanded porphyrins, synthetic analogues of natural tetrapyrrolic pigments (e.g. heme and chlorophyll), constitute as potentially attractive platforms due to their NIR-II absorptivity and their ability to respond to stimuli. Here, we evaluate two expanded porphyrins, naphthorosarin (1) and octaphyrin (4), as stimuli responsive PA contrast agents for functional PAI. Both undergo proton-coupled electron transfer to produce species that absorb well in the NIR-II region. Octaphyrin (4) was successfully encapsulated into 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) (DSPE-PEG2000) nanoparticles to afford OctaNPs. In combination with PAI, OctaNPs allowed changes in the acidic environment of the stomach to be visualized and cancerous versus healthy tissues to be discriminated.In this study, two expanded porphyrins, octaphyrin and naphthorosarin were evaluated as potential PA agents. The nanoparticle encapsulation of octaphyrin successfully enabled the visualization of acidic environments and the discrimination between cancerous and healthy tissues. 相似文献
479.
Sabrina Groth Christoph Budke Timo Weber Susanne Neugart Sven Brockmann Martina Holz Bao Chau Sawadski Diemo Daum Sascha Rohn 《Molecules (Basel, Switzerland)》2021,26(9)
Notable parts of the population in Europe suffer from allergies towards apples. To address this health problem, the analysis of the interactions of relevant allergens with other substances such as phenolic compounds is of particular importance. The aim of this study was to evaluate the correlations between the total phenolic content (TPC), polyphenol oxidase (PPO) activity, antioxidant activity (AOA), and the phenolic compound profile and the content of the allergenic protein Mal d 1 in six apple cultivars. It was found that the PPO activity and the content of individual phenolic compounds had an influence on the Mal d 1 content. With regard to the important constituents, flavan-3-ols and phenolic acids, it was found that apples with a higher content of chlorogenic acid and a low content of procyanidin trimers and/or epicatechin had a lower allergenic potential. This is probably based on the reaction of phenolic compounds (when oxidized by the endogenous PPO) with proteins, thus being able to change the conformation of the (allergenic) proteins, which further corresponds to a loss of antibody recognition. When apples were additionally biofortified with selenium, the composition of the apples, with regard to TPC, phenolic profile, AOA, and PPO, was significantly affected. Consequently, this innovative agronomic practice seems to be promising for reducing the allergenic potential of apples. 相似文献