全文获取类型
收费全文 | 164篇 |
免费 | 13篇 |
国内免费 | 1篇 |
专业分类
化学 | 133篇 |
晶体学 | 1篇 |
力学 | 1篇 |
数学 | 28篇 |
物理学 | 15篇 |
出版年
2023年 | 2篇 |
2022年 | 4篇 |
2021年 | 10篇 |
2020年 | 4篇 |
2019年 | 5篇 |
2018年 | 9篇 |
2017年 | 4篇 |
2016年 | 4篇 |
2015年 | 7篇 |
2014年 | 9篇 |
2013年 | 14篇 |
2012年 | 13篇 |
2011年 | 19篇 |
2010年 | 9篇 |
2009年 | 7篇 |
2008年 | 15篇 |
2007年 | 10篇 |
2006年 | 9篇 |
2005年 | 11篇 |
2004年 | 6篇 |
2003年 | 1篇 |
2002年 | 3篇 |
2001年 | 1篇 |
1999年 | 1篇 |
1997年 | 1篇 |
排序方式: 共有178条查询结果,搜索用时 0 毫秒
31.
Merlet D Béguin L Courtieu J Giraud N 《Journal of magnetic resonance (San Diego, Calif. : 1997)》2011,209(2):315-322
The application of the G-SERFph pulse sequence is presented on enantiomeric mixtures dissolved in a chiral liquid crystal. It aims at editing, within one single 2D spectrum, every proton coupling which is experienced by a given proton site in the molecule, and leads to real phased T-edited spectroscopy (T=J+2D). This NMR experiment is based on the combination of homonuclear semi-selective refocusing techniques with a spatial frequency encoding of the sample. This approach, which consists in handling selectively each coupling in separate cross sections of the sample, is applied to the visualization of enantiomers dissolved in a chiral liquid crystalline phase. Advantages and limits of this methodology are widely discussed. 相似文献
32.
The stereoselective synthesis of both cis- and trans-β-fluorostyrene derivatives from a common intermediate, (Z)-1-aryl-2-fluoro-1-(trimethylsilyl)ethenes, is described. The trans isomers are obtained by a stereospecific replacement of the silyl group in the presence of water and a fluoride source, whereas the preparation of the cis isomers is achieved by a bromination/desilicobromination sequence followed by reduction of the newly created C-Br bond. A stereoselective transformation of both stereoisomers of β-fluorostyrene is also presented. 相似文献
33.
34.
Huber G Beguin L Desvaux H Brotin T Fogarty HA Dutasta JP Berthault P 《The journal of physical chemistry. A》2008,112(45):11363-11372
The interaction of xenon with cryptophane derivatives is analyzed by NMR by using either thermal or hyperpolarized noble gas. Twelve hosts differing by their stereochemistry, cavity size, and the nature and the number of the substituents on the aromatic rings have been included in the study, in the aim of extracting some clues for the optimization of (129)Xe-NMR based biosensors derived from these cage molecules. Four important properties have been examined: xenon-host binding constant, in-out exchange rate of the noble gas, chemical shift, and relaxation of caged xenon. This work aims at understanding the main characteristics of the host-guest interaction in order to choose the best candidate for the biosensing approach. Moreover, rationalizing xenon chemical shift as a function of structural parameters would also help for setting up multiplexing applications. Xenon exhibits the highest affinity for the smallest cryptophane, namely cryptophane-111, and a long relaxation time inside it, convenient for conservation of its hyperpolarization. However, very slow in-out xenon exchange could represent a limitation for its future applicability for the biosensing approach, because the replenishment of the cage in laser-polarized xenon, enabling a further gain in sensitivity, cannot be fully exploited. 相似文献
35.
Yancheva E Paneva D Danchev D Mespouille L Dubois P Manolova N Rashkov I 《Macromolecular bioscience》2007,7(7):940-954
Polyelectrolyte complexes (PECs) between (quaternized) poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) and (crosslinked) N-carboxyethylchitosan (CECh) or poly(2-acrylamido-2-methylpropane sodium sulfonate) (PAMPSNa) were prepared and characterized in terms of their stability, equilibrium water content, and surface morphology. The evaluation of the behavior of the studied PECs in contact with blood revealed that the (crosslinked) CECh/(quaternized) PDMAEMA complexes had lost the inherent PDMAEMA cytotoxicity but still preserved haemostatic activity. In contrast, the complex formation between (quaternized) PDMAEMA and PAMPSNa allowed the preparation of materials with improved blood compatibility. 相似文献
36.
37.
Condensed tannins take an important part in the sensory quality of food and beverage. Sensory analyses are usually carried out with various tannin fractions isolated from food or beverage, and their interpretation are limited by the lack of knowledge in the fine and accurate molecular composition of the tannin fractions. Besides, the studies of the chemical reactivity conducted in model solutions with ‘simple’ flavanols allow a better understanding of their evolution pathways, but they cannot take into account their reactivity as polymers, specifically regarding oxidation. In particular, competition between intramolecular and intermolecular reactions may strongly impact on the tannin structures (size, branching and conformation) and consequently on their properties. An ultra‐performance liquid chromatography‐mass spectrometry electrospray ionization mass spectrometer analytical method was thus developed in order to identify oxidized tannins generated by autoxidation. Given the difficulties to separate and detect tannins with high DP, samples were depolymerized by chemical depolymerization prior to analysis. Since the linkages created by oxidation are not cleavable in the usual depolymerization conditions (contrarily to the original interflavanic linkages), specific oxidation residues are released from tannins structures after their autoxidation. Oxidation markers of both intermolecular and intramolecular mechanisms have been identified; these are mainly dimers and trimers, more or less oxidized, and some contain additional hydroxyl groups. Furthermore, the nature of the subunits (extension vs terminal) making up these dimers and trimers was clearly established. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
38.
39.
Jean-Charles Boisson Laetitia Jourdan El-Ghazali Talbi Dragos Horvath 《Journal of Mathematical Modelling and Algorithms》2010,9(2):195-208
In this article, the impact of single-objective methods as intensification factors in a multi-objective approach is presented
for the flexible docking problem. Based on a novel tri-objective model, a parallel multi-objective genetic algorithm has been
designed. However, due to the high variability of the energy objective, intensification methods focused on this objective
have been also included in order to improve the convergence speed of the genetic algorithm and the quality of the results.
The corresponding approach, combining single- and multi-objective methods, has been proved efficient according to the tested
instances and the quality criterion used. 相似文献
40.
Marie-Éléonore Marmion Laetitia Jourdan Clarisse Dhaenens 《Journal of Mathematical Modelling and Algorithms》2013,12(1):3-26
Landscape analysis has been identified as a promising way to develop efficient optimization methods. Nevertheless, the links between properties of the landscape and efficiency of methods is not easy to understand. In this article, we propose to give a contribution in this field using a vehicle routing problem as an illustration. Metaheuristics use a neighborhood operator that connects solutions of the search space. Thus, this operator acts on the dynamics of the search and impacts metaheuristics efficiency. Therefore, we characterize two landscapes differenciated by their neighborhood function and then, we analyze the performance of classical metaheuristics using one or the other neighborhood operator. Finally, a discussion provides insights on the relations between results of the landscape analysis and results of methods performance. 相似文献