Magnolol as a Potential Anticancer Agent: A Proposed Mechanistic Insight

Cancer is a serious disease with high mortality and morbidity worldwide. Natural products have served as a major source for developing new anticancer drugs during recent decades. Magnolol, a representative natural phenolic lignan isolated from Magnolia officinali, has attracted considerable attention for its anticancer properties in recent years. Accumulating preclinical studies have demonstrated the tremendous therapeutic potential of magnolol via a wide range of pharmacological mechanisms against cancer. In this review, we summarized the latest advances in preclinical studies investigating anticancer properties of magnolol and described the important signaling pathways explaining its underlying mechanisms. Magnolol was capable of inhibiting cancer growth and metastasis against various cancer types. Magnolol exerted anticancer effects through inhibiting proliferation, inducing cell cycle arrest, provoking apoptosis, restraining migration and invasion, and suppressing angiogenesis. Multiple signaling pathways were also involved in the pharmacological actions of magnolol against cancer, such as PI3K/Akt/mTOR signaling, MAPK signaling and NF-κB signaling. Based on this existing evidence summarized in the review, we have conclusively confirmed magnolol had a multi-target anticancer effect against heterogeneous cancer disease. It is promising to develop magnolol as a drug candidate for cancer therapy in the future.     

On C classifications of hyperbolic vector fields

In this paper we study smooth classification of hyperbolic vector fields based on their linear approximations only and obtain the following. On Rⁿ, n?5, with only two kinds of exceptions, any two hyperbolic vector fields with generic nonlinear parts and where A_i are n×n matrices, are C¹ conjugate to each other if and only if A₁ and A₂ are strictly similar, and they are C¹ orbitally equivalent if and only if A₁ and A₂ are similar.     

Synthesis of spinel CuCo2O4 nanoparticles and its application in p-nitrophenol reduction

Journal of Sol-Gel Science and Technology - CuCo2O4 spinel nanoparticles were successfully preparedvia a sol–gel method, which were firstly employed in catalytic reduction of p-nitrophenol to...     

轴向冲击载荷下开孔薄壁方管吸能特性的研究

利用有限元软件ABAQUS对开孔薄壁方管在轴向冲击载荷作用下的变形规律与吸能特性进行了数值仿真分析,并根据数值模拟结果进行了多目标优化。在薄壁方管的每个侧面上开六个长方形孔,通过改变长方形孔的长度和宽度来研究开孔薄壁方管的耐撞性。结果表明:在研究的范围内,除开孔尺寸为20mm×5mm的薄壁方管外,其余开孔薄壁方管的破坏模式为外延式破坏模式,其变形过程为动态渐进屈曲;当开孔长度增大时,开孔薄壁方管初始峰值力减小;当开孔长度和宽度同时增大时,开孔薄壁方管平均载荷均减小;开孔面积越大,管吸收的能量和比吸能越小;开孔长度不变时,随着宽度的增大压缩力效率降低,当宽度不变时,随着长度的增大压缩力效率增大。基于开孔方管的数值模拟结果构造了响应面模型并对其进行了多目标优化,给出了Pareto前沿图,可根据各目标的偏好确定方管的开孔尺寸。     

梯度蜂窝夹芯板在爆炸荷载作用下的动力响应

利用弹道冲击摆锤系统对分层梯度蜂窝夹芯板在爆炸荷载下的动力响应进行了实验研究,分析了梯度蜂窝夹芯板在爆炸荷载作用下的变形失效模式,并与传统非梯度蜂窝夹芯板的抗爆性能做了对比。通过一维应力波理论,分析了应力波在梯度芯层中的传播规律。应力波透射系数在梯度试件中比非梯度芯层中小,而且相对密度递减的芯层组合有最小的应力波透射系数。综合考虑结构变形失效模式,后面板挠度,芯层压缩量以及应力波传播特点得到:分层梯度蜂窝夹芯板的抗爆性能明显优于传统的非梯度夹芯板,在所研究的荷载范围内,芯层相对密度从大到小排列试件的抗爆性能相对较好。     

激波在不同三角楔面内传播特性的数值研究

激波在收缩管内的反射与聚焦会形成高温高压区,点燃可燃混合气并诱导爆轰,因此对爆轰发动机的点火具有重要意义。本文基于二维N-S方程,结合五阶WENO格式,对马赫数为6的正激波在三角形楔面内的反射与聚焦现象进行了数值研究。结果表明,楔面顶角的变化对激波的反射类型以及聚焦均有明显的影响:随着顶角的增加,激波的反射类型从马赫反射向过渡马赫反射和双马赫反射转变,且壁面上的前向射流更加明显;三波点第一次碰撞产生的高温高压区足够满足可燃混合气体的点火条件,且其温度与压力值随顶角的增加而增大;当激波在楔面上发生临界双马赫反射时,温度与压力达到最大;当顶角增加到一定值时,激波在楔面反射转变为常规反射,不会产生激波对碰,因而没有高温高压区。     

惯性/高度表组合导航系统卡尔曼滤波算法的浑沌及其控制

本文研究了组合导航系统中应用卡尔曼滤波器进行信息最优估计时的浑沌现象和浑沌 控制,并以惯性系统和高度定位组合导航系统为例,研究了当载体受周期激励时,由于采样频 率选择不当,卡尔曼滤波算法将导致浑沌结果,从而影响系统导航精度。本文还提出了利用变 步长的参数调整法来抑制这种浑沌。     

航海-ⅢG陀螺罗经电源系统

本文介绍航海-ⅢG型陀螺罗经用大功率三相正弦波脉宽调制中频静止电源,它由EPROM构成的可编程正弦波脉宽调制信号发生器、A/D转换器组成的幅度调节器以及场效应管功率放大器等电路组成,输出频率、幅度、相位稳定的纯三相正弦波,具有效率高、负载能力强等优点,该电源还设置了多种故障检测、报警和多重过载保护电路,整机性能稳定,工作可靠.它不仅适用于航海型陀螺罗经的供电,对于其他功率较大的中频供电场合也是适宜的.     

Synthesis and thermal properties of antimony doped tin oxide/waterborne polyurethane nanocomposite films as heat insulating materials

The waterborne polyurethane (WPU) was synthesized from the polycondensation between isophorone diisocyanate (IPDI) and polyoxypropylene glycol (N‐210) and then dispersed into water. Subsequently, the WPU emulsion was modified with antimony doped tin oxide (ATO) nanoparticle by ultrasonic dispersion. The ATO/WPU emulsion was cast onto Teflon molds. After being dried, ATO/WPU films were prepared. TEM indicated that the ATO nanoparticles were homogeneously dispersed in the polymer matrix at the nanometer scale. DSC showed that the ATO/WPU nanocomposites displayed increased glass transition temperatures compared to the control WPU. The mechanical properties of the films were characterized by dynamic‐mechanical analysis (DMA). The higher glass transition temperature and storage modulus indicates the superior mechanical properties of WPU modified by ATO nanoparticles over the conventional unmodified WPU. The thermal behaviors of the films were evaluated by thermogravimetric analysis (TGA). It could be found that the incorporation of ATO into WPU can improve the thermal stability dramatically. The results from UV–visible–near infrared spectra indicated that the ATO/WPU films could decrease the infrared transmission effectively. The heat‐insulation measurements showed that glass coated with ATO/WPU films possessed better heat‐insulating effect than empty glass. Copyright © 2010 John Wiley & Sons, Ltd.