Conformational implications of some nucleotide sequences

The conformational properties of some nucleotide sequences result in their ability to bind specifically some ligands or tobe recognized by specific proteins. In order to investigate the dependence of conformational behavior of the DNA duplex on nucleotide sequence, we analyzed the interaction energy of nucleic acid bases as a function of conformational parameters and base sequence. Extended regions of minimum energy values were found for different sequences. Although these regions (valleys) largely overlap, each one shows specificity for a particular sequence. This suggests that a specific pathway of changes in conformational parameters exists for each sequence. the changes may be accompanied by considerable shifts (2–3 Å) of the atom positions and an only slight variation (1–2 kcal/mol) of energy. Even small shifts in other directions can cause a drastic energy increase. For some nucleotide sequences, the energetically preferable conformations are the B-like ones (e.g., ApA, TpA), whereas for others the A-like ones are preferable (e.g., GpG, ApT). IN general, Pyr-Pur sequences have a tendency to a larger τ and smaller H and D than Pur-Pyr sequences. A large body of experimental data on nucleic acid structure in fibers and in solutions can be explained by results obtained.     

Influence of the energy and velocity spread in the electron beam on the starting conditions and efficiency of a gyrotron

We study theoretically the influence of the spread of initial energies and velocities in the electron beam on the starting conditions and efficiency of a gyrotron. We compare various analytical and numerical models and the results of experimental studies of gyrotrons in which the interaction takes place at the first and second harmonics of the cyclotron frequency. The aftercavity interaction of the electron beam with the high-frequency field in the output waveguide transition is taken into account. The influence of the energy spread on the recuperation efficiency is estimated. Permissible spreads of the initial energies and electron velocities are determined. __________ Translated from Izvestiya Vysshikh Uchebnykh Zavedenii, Radiofizika, Vol. 49, No. 2, pp. 121–133, February 2006.     

Synthesis and conformational study of 1,2,3,4,5,6,7,8-octahydro-1,6-naphthiridines

A new class of endocyclic enamines, 1,6-disubstituted 1,2,3,4,5,6,7,8-octahydro-1,6-naphthiridines, was synthesized from 4-piperidone imines by successive subjecting the latter to lithiation with lithium diethylamide, to alkylation with 1-bromo-3-chloropropane, and to intramolecular cyclization. All stages were carried out as a unique process without isolation of the intermediate compounds. A thorough optimization of the process conditions, workup, and product storage was carried out. The conformational study of 1,6-disubstituted 1,2,3,4,5,6,7,8-octahydro-1,6-naphthiridines was performed.     

An unusual transformation of perfluorinated 1- and 3-phenylpropenes to polyfluorochloroindanes by the action of AlCl3

The reaction of perfluorinated 1- and 3-phenylpropenes with AlCl₃ gives polyfluorochloroindanes as the result of an intramolecular cyclization, apparently, by an electrophilic pathway.Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 12, pp. 2854–2857, December, 1989.     

Some quantum mechanical problems in Lobachevsky space

Quantum mechanical problems are considered for potentials satisfying Bertrand's problem in Lobachevsky space. The self-adjointness of the corresponding Schrödinger operators is proved. The energy levels are calculated both from the Schrödinger equation and by means of the Bohr-Sommerfeld method. The effect of the quantum binding of classically infinite motion was discovered and is presented for the first time. It is shown that the quasi-classical limit is equivalent, in a sense, to the Euclidean limit.Translated from Teoreticheskaya i Matematicheskaya Fizika, Vol. 109, No. 3, pp. 395–405, December, 1996.     

On the moment characteristics of distributions

We study different moment characteristics of (mostly discrete) distributions: general, central, binomial, and factorial moments, and also ordinary and factorial semi-invariants. We establish the relations that connect various kinds of “moments” of arbitrary order, and we derive recursion formulas. Translated fromMetody Matematicheskogo Modelirovaniya, pp. 34–41, 1998.     

Lyapunov’s direct method in estimates of topological entropy

An upper estimate for the topological entropy of a dynamical system defined by a system of ODE is obtained. The estimate involves the Lyapunov functions and Losinskii’s logarithmic norm. The proof uses the known fact that the topological entropy of a mapping acting in a compact space K can be estimated via the fractal dimension of K. Bibliography: 28 titles. Translated fromZapiski Nauchnykh Seminarov POMI, Vol. 231, 1995, pp. 62–75. Translated by V. A. Boichenko and G. A. Leonov.