全文获取类型
收费全文 | 120篇 |
免费 | 0篇 |
专业分类
化学 | 73篇 |
力学 | 9篇 |
数学 | 11篇 |
物理学 | 27篇 |
出版年
2023年 | 2篇 |
2022年 | 1篇 |
2021年 | 5篇 |
2020年 | 3篇 |
2019年 | 5篇 |
2014年 | 3篇 |
2013年 | 8篇 |
2012年 | 16篇 |
2011年 | 11篇 |
2010年 | 7篇 |
2009年 | 3篇 |
2008年 | 5篇 |
2007年 | 3篇 |
2006年 | 8篇 |
2005年 | 5篇 |
2004年 | 5篇 |
2003年 | 1篇 |
2002年 | 3篇 |
2001年 | 3篇 |
2000年 | 6篇 |
1999年 | 5篇 |
1998年 | 5篇 |
1997年 | 1篇 |
1996年 | 3篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1989年 | 1篇 |
排序方式: 共有120条查询结果,搜索用时 15 毫秒
91.
Sung-Kyu Kim Su-Dong Cho Deok-Heon Kweon Sang-Gyeong Lee Joo-Wha Chung Sung Chul Shin Yong-Jin Yoon 《Journal of heterocyclic chemistry》1996,33(2):245-248
1-Alkyl-4,5-dichloropyridazin-6-oncs and (4,5-dichloro-6-oxopyridazin-1-yl)methylcarboxylates were synthesized from 4,5-dichloro-1-hydroxymethylpyridazin-6-one and the corresponding alkyl halides or carboxylic acid chlorides. Also the reaction mechanisms via a fragmentation of retro-ene type are discussed. 相似文献
92.
Influence of Extracellular Polymeric Substances on Membrane Fouling and Cleaning in a Submerged Membrane Bioreactor 总被引:2,自引:0,他引:2
Chackrit Nuengjamnong Ji Hyang Kweon Jinwoo Cho Kyu-Hong Ahn Chongrak Polprasert 《Colloid Journal》2005,67(3):351-356
There is little information available on the correlation between the concentration of extracellular polymeric substances (EPS) and membrane fouling as well as cleaning efficiency. In this study, two lab-scale flat submerged membrane bioreactors (SMBRs) at sludge retention times (SRTs) of 25 and 250 days were operated at a constant permeate flux (12.5 l m−2 h−1). Samples of activated sludge were tested to quantify the concentration of extractable EPS using cation exchange resin. Batch filtration tests were also performed to determine the specific cake resistances and the flux recoveries. The extractable EPS and protein concentrations were relatively low at the prolonged SRT, leading to cake layers easily removable by the physical manual cleaning or the de-ionized water backwashing and the chemical cleaning with sodium hypochlorite methods. The extent of flux recoveries (both in SMBRs and batch filtration tests) and macroscopic as well as microscopic images indicated that the chemical cleaning could enhance the effectiveness of cleaning. The membrane fouling and cleaning mechanisms were also discussed.__________From Kolloidnyi Zhurnal, Vol. 67, No. 3, 2005, pp. 392–397.Original English Text Copyright © 2005 by Chackrit Nuengjamnong, Ji Hyang Kweon, Jinwoo Cho, Kyu-Hong Ahn, Chongrak Polprasert.This article was submitted by the authors in English. 相似文献
93.
Max Wienhold Byeongseok Kweon Dr. Calum McLaughlin Matthias Schmitz Till J. B. Zähringer Dr. Constantin G. Daniliuc Prof. Dr. Christoph Kerzig Prof. Dr. Ryan Gilmour 《Angewandte Chemie (International ed. in English)》2023,62(27):e202304150
Amide groups are pervasive across the chemical space continuum, where their structural and pharmacological importance, juxtaposed with the hydrolytic vulnerabilities, continues to fuel bioisostere development. Alkenyl fluorides have a venerable history as effective mimics (Ψ[CF=CH]) owing to the planarity of the motif and intrinsic polarity of the C(sp2)−F bond. However, emulating the s-cis to the s-trans isomerisation of a peptide bond with fluoro-alkene surrogates remains challenging, and current synthetic solutions only enable access to a single configuration. Through the design of an ambiphilic linchpin based on a fluorinated β-borylacrylate, it has been possible to leverage energy transfer catalysis to affect this unprecedented isomerisation process: this provides geometrically-programmable building blocks that can be functionalised at either terminus. Irradiation at λmax=402 nm with inexpensive thioxanthone as a photocatalyst enables rapid, effective isomerisation of tri- and tetra-substituted species (up to E/Z 98 : 2 in 1 h), providing a stereodivergent platform for small molecule amide and polyene isostere discovery. Application of the methodology in target synthesis and initial laser spectroscopic studies are disclosed together with crystallographic analyses of representative products. 相似文献
94.
Zero path-length difference interferometry is demonstrated using the filter response of an unbalanced interferometer to the
spontaneous/spontaneous beat noise spectrum of an amplified spontaneous emission source. The method is applicable to path-length
differences ranging from a few centimeters to several kilometers. 相似文献
95.
Hyun‐A Chung Young‐Jin Kang D. H. Kweon Woo Song Lee Yong‐Jin Yoon 《Journal of heterocyclic chemistry》2000,37(6):1443-1446
This paper presents the synthesis of 1‐[(pyrazol‐3‐yl)methyl]pyridazin‐6‐ones from ethyl 4‐(4,5‐dichloro‐6‐oxopyridazin‐1‐yl)‐3‐oxobutanoate. 相似文献
96.
97.
Cancer cachexia syndrome is a major cause of morbidity and mortality in cancer patients in the advanced stage. It is a devastating disorder characterized by nutritional impairment, weakness, and wasting, and it affects treatment success and quality of life. Two major symptoms of cancer cachexia are anorexia and weight loss. Weight loss in cachexia is not reversed through increased food intake, suggesting that anorexia and weight loss in cancer patients are regulated by independent molecular mechanisms. Although the wasting phenotype mostly occurs in skeletal muscle and adipose tissue, other organs, such as the brain, liver, pancreas, heart, and gut, are also involved in cachexia. Thus, cachexia is a multiorgan syndrome. Although the molecular basis of cancer cachexia-induced weight loss is known, the mechanism underlying anorexia is poorly understood. Here, we highlight our recent discovery of a new anorexia mechanism by which a tumor-derived humoral factor induces cancer anorexia by regulating feeding-related neuropeptide hormones in the brain. Furthermore, we elucidated the process through which anorexia precedes tissue wasting in cachexia. This review article aims to provide an overview of the key molecular mechanisms of anorexia and tissue wasting caused by cancer cachexia.Subject terms: Cancer metabolism, Cancer metabolism 相似文献
98.
Hae Yong Kweon Joo Hong Yeo Kwang Gill Lee Yong Woo Lee Young Hwan Park Joong‐Hee Nahm Chong‐Su Cho 《Macromolecular rapid communications》2000,21(18):1302-1305
Effects of the concentration of poloxamer 407, temperature, and the concentration of sericin on the gelation of silk sericin (SS) were studied. Gelation of SS was accelerated with an increase in poloxamer concentration and temperature. The sol‐gel transition of SS became irreversible with respect to the temperature in the presence of poloxamer, whereas the sol‐gel transition of SS itself was reversible. Infrared (IR) and circular dichroism (CD) spectra show that the conformational change of SS in the presence of poloxamer was accelerated from random coil to β‐structure. X‐ray diffraction and differential scanning calorimetry (DSC) show that the crystalline structure of poloxamer in the mixture was affected by the presence of SS and that its melting temperature was shifted to lower temperature with increasing SS content, indicating an interaction between poloxamer and SS through hydrogen and hydrophobic bondings. 相似文献
99.
This study was conducted to examine the effects of dietary grape extracts on preneoplastic foci formation in rat hepatocarcinogenesis, and related hepatic enzymes. Male Sprague-Dawley rats were fed basal diet or grape diet containing 15% concentrated grape extracts (68 bricks). The grape diet groups were divided into whole-period grape diet group (DEN-GW; grape diet group fed throughout experimental period) and postinitiation grape diet group (DEN-GP; grape diet group fed from post initiation stage) according to the starting time point of the grape diet. Hepatocarcinogenesis was induced by diethylnitrosamine (DEN; 200 mg/kg bw) and 2/3 partial hepatectomy (DEN-B; DEN-treated basal diet group, DEN-GW, and DEN-GP groups), while the control group treated with saline and sham operation (Control group). The formation of placental glutathione (GSH) S-transferase positive (GST-P+) foci in DEN-GW group was moderately but significantly suppressed, however, not in DEN- GP group. Thiobarbituric acid reactive substances content of DEN-GW group was significantly lower than that of DEN-B group. The activity of fatty acid synthase (FAS) in the grape diet groups was decreased about 1/2 of the DEN-B group. The content of GSH and GSH peroxidase activity were increased by carcinogen treatment, but not modulated by grape diet. The activities of GSH S-transferase, p-nitrophenol hydroxylase, and catalase were not affected by diet or treatment. Conclusively, the grape diet-induced reduction of FAS activity that was expressed highly in neoplastic tissues, might be one of the contributing mechanisms of hepatic cancer prevention. 相似文献
100.
Park Jae-Bum Kim Jin-Seong Kweon Deok-Ho Kweon Dae-Hyuk Seo Jin-Ho Ha Suk-Jin 《Applied biochemistry and biotechnology》2019,189(2):459-470
Applied Biochemistry and Biotechnology - Xylitol is a valuable substance utilized by food and biochemical industries. NAD(P)H-dependent xylose reductase (XR)—encoded by the yeast KmXYL1... 相似文献