Wisanin und andere amide der 5-(2-methoxy-4,5-methylendioxyphenyl)-2,4-pentadiensäure: Synthesen,spektroskopische untersuchungen und prüfung auf antibakterielle wirksamkeit

Wisanine, a constituent of piper guineense (a plant of which antibacterial activity has been reported and other amides of 5 - (2 - methoxy - 4, 5 - methylenedioxyphenyl) - pentadienoic acid were synthesized from 3,4 -dioxymethylen - phenel and investigated spectroscopically. The amides prepared have been tested against grampositive and gramnegative bacteria. Only some of the amides prepared show weak antibacterial activity.     

The neuroblast and angioblast chemotaxic factor SDF-1 (CXCL12) expression is briefly up regulated by reactive astrocytes in brain following neonatal hypoxic-ischemic injury

Background  

Stromal cell-derived factor 1 (SDF-1 or CXCL12) is chemotaxic for CXCR4 expressing bone marrow-derived cells. It functions in brain embryonic development and in response to ischemic injury in helping guide neuroblast migration and vasculogenesis. In experimental adult stroke models SDF-1 is expressed perivascularly in the injured region up to 30 days after the injury, suggesting it could be a therapeutic target for tissue repair strategies. We hypothesized that SDF-1 would be expressed in similar temporal and spatial patterns following hypoxic-ischemic (HI) injury in neonatal brain.     

Structure of neutron-rich nuclei around the N = 126 closed shell; the yrast structure of 205Au126 up to spin-parity I^{\pi} = (19/2+)

Heavy neutron-rich nuclei have been populated through the relativistic fragmentation of a $\ensuremath ^{208}_{\ 82}{\rm Pb}$ beam at $\ensuremath E/A = 1$ GeV on a $\ensuremath 2.5 {\rm g/cm^2}$ thick Be target. The synthesised nuclei were selected and identified in-flight using the fragment separator at GSI. Approximately 300 ns after production, the selected nuclei were implanted in an $\ensuremath \sim 8$ mm thick perspex stopper, positioned at the centre of the RISING $\ensuremath \gamma$ -ray detector spectrometer array. A previously unreported isomer with a half-life $\ensuremath T_{1/2} = 163(5)$ ns has been observed in the N = 126 closed-shell nucleus $\ensuremath ^{205}_{\ 79}{\rm Au}$ . Through $ \gamma$ -ray singles and $ \gamma$ - $ \gamma$ coincidence analysis a level scheme was established. The comparison with a shell model calculation tentatively identifies the spin-parity of the excited states, including the isomer itself, which is found to be $\ensuremath I^{\pi} = (19/2^+)$ .