Die Anwendung eines neuen Reagenses zur gravimetrischen Bestimmung einiger Metalle

Ohne Zusammenfassung     

Homochiral column structure of rac- and lambda-tris(ethylenediamine)cobalt(III) cyclotriphosphate dihydrate in crystal structures and cation-anion association in aqueous solution

rac- and Lambda-tris(ethylenediamine)cobalt(III) cyclotriphosphate dihydrate with the chemical formulas rac-[Co(en)(3)]P(3)O(9).2H(2)O (1) and Lambda-[Co(en)(3)]P(3)O(9).2H(2)O (2) were synthesized, and their crystal structures were determined by single-crystal X-ray analyses. In 1, the cationic complex molecule [Co(en)(3)](3+) with the Delta or Lambda enantiomer and cyclotriphosphate anion are alternately arrayed and connected by multiple hydrogen bonds to form a homochiral column structure. Adjacent homochiral columns with different chirality for 1 are connected by intercolumn hydrogen bonds through P(3)O(9)(3)(-) anions, as the bridging groups, to form a tetrameric cyclic cylindrical structure, while the adjacent columns with the same chirality are connected for 2 to form the cyclic cylindrical structure. All 6 amino groups per [Co(en)(3)](3+) participate in the formation of 12 hydrogen bonds, in which 8 hydrogen bonds contribute to the construction of a homochiral column and the remaining 4 hydrogen bonds contribute to the intercolumn interactions. The circular dichroism spectrum of the aqueous solution of Lambda-[Co(en)(3)](3+) changes drastically when excess P(3)O(9)(3)(-) is added, and this change is explained by ion-pair formation. The thermodynamic association constant of [Co(en)(3)](3+) with P(3)O(9)(3)(-), calculated from the conductivity data, was log K = 4.26 at 25 degrees C.     

Mikrogravimetrische Ni-Bestimmung mit Oxalendiamidoxim

Zusammenfassung Das Oxalendiamidoxim hat sich als billiges und gut geeignetes, wasserlösliches Reagens für quantitative Nickelbestimmungen erwiesen. Es wird dafür der Name Niccolox vorgeschlagen.     

Die Anwendung eines neuen Reagenses zur gravimetrischen Bestimmung einiger Metalle

Ohne Zusammenfassung     

Nuclear structure explored by β-delayed decay spectroscopy of spin-polarized radioactive nuclei at TRIUMF ISAC-1

Spin-polarized radioactive nuclear beams at TRIUMF enable a new spectroscopic method which efficiently assigns spins and parities of the daughter levels by taking advantage of the asymmetric β-decay of the polarized parent nucleus. This method was successfully applied to structure studies of ²⁹Mg and ³⁰Mg in connection with the physics of the “island of inversion”. In ²⁹Mg, two low-lying levels with intruder configuration were assigned. In ³⁰Mg, coexistence of spherical shape, prolate shape and γ-collectivity was strongly suggested.     

Statistische Auswertung der massenspektrometrischen Gruppenanalyse von Benzinen

A possibility has been found to carry out corrections on the mass spectrometric determination of the hydrocarbon groups in non-olefinic petrols on the basis of the measurements of a single test mixture with sufficient accuracy. A simple method is described for the elimination of the systematic errors in petrol analyses carried out with other instruments than those employed for the calibration factors. The results have also confirmed the conclusions of Benz that with such a method in different laboratories no extensive calibrations are required.     

Development and Validation of a GC–MS Method for the Determination of Methyl and Ethyl Camphorsulfonates in Esomeprazole Magnesium

A rapid gas chromatography–mass spectrometry method for the identification and determination of two carcinogenic impurities viz. methyl camphorsulfonate (MCS) and ethyl camphorsulfonate (ECS) in esomeprazole magnesium (EOM) is developed for the first time. The factors affecting method development and the fragmentation patterns of MCS and ECS based on the mass spectral analysis are described. The limit of detection and limit of quantitation values for both compounds were established as 3 and 10 ppm, respectively with respect to 50 mg mL^?1 of EOM. The method is linear within the range of 10–120 ppm and found to be precise, accurate, specific and robust.     

Anti-Inflammatory and Anti-Rheumatic Potential of Selective Plant Compounds by Targeting TLR-4/AP-1 Signaling: A Comprehensive Molecular Docking and Simulation Approaches

Plants are an important source of drug development and numerous plant derived molecules have been used in clinical practice for the ailment of various diseases. The Toll-like receptor-4 (TLR-4) signaling pathway plays a crucial role in inflammation including rheumatoid arthritis. The TLR-4 binds with pro-inflammatory ligands such as lipopolysaccharide (LPS) to induce the downstream signaling mechanism such as nuclear factor κappa B (NF-κB) and mitogen activated protein kinases (MAPKs). This signaling activation leads to the onset of various diseases including inflammation. In the present study, 22 natural compounds were studied against TLR-4/AP-1 signaling, which is implicated in the inflammatory process using a computational approach. These compounds belong to various classes such as methylxanthine, sesquiterpene lactone, alkaloid, flavone glycosides, lignan, phenolic acid, etc. The compounds exhibited different binding affinities with the TLR-4, JNK, NF-κB, and AP-1 protein due to the formation of multiple hydrophilic and hydrophobic interactions. With TLR-4, rutin had the highest binding energy (−10.4 kcal/mol), poncirin had the highest binding energy (−9.4 kcal/mol) with NF-κB and JNK (−9.5 kcal/mol), respectively, and icariin had the highest binding affinity (−9.1 kcal/mol) with the AP-1 protein. The root means square deviation (RMSD), root mean square fraction (RMSF), and radius of gyration (RoG) for 150 ns were calculated using molecular dynamic simulation (MD simulation) based on rutin’s greatest binding energy with TLR-4. The RMSD, RMSF, and RoG were all within acceptable limits in the MD simulation, and the complex remained stable for 150 ns. Furthermore, these compounds were assessed for the potential toxic effect on various organs such as the liver, heart, genotoxicity, and oral maximum toxic dose. Moreover, the blood–brain barrier permeability and intestinal absorption were also predicted using SwissADME software (Lausanne, Switzerland). These compounds exhibited promising physico-chemical as well as drug-likeness properties. Consequently, these selected compounds portray promising anti-inflammatory and drug-likeness properties.