Studies on the optimal immunization schedule of experimental animals. VI. Antigen dose-response of aluminum hydroxide-aided immunization and booster effect under low antigen dose

The dose-response relationships of a viomycin (VM) immunogen for total immunoglobulin (Ig) G and anti-VM antibody response of mouse using aluminum hydroxide as adjuvant was studied. The condition required to absorb a protein on aluminum gel was first established. The effective immunogen dose for total and specific IgG response of mouse using aluminum hydroxide as the adjuvant was found to be in the narrow range of 5 to 20 micrograms, and 10 micrograms per mouse was optimal. The most effective number and intervals of booster injections were studied; when mice were immunized with a lower antigen dose than the optimal, both the number and interval period of booster injections greatly affected the immune response; the more boosters were given, the higher was the response level of specific IgG. The results are contrary to those obtained by immunizing with the optimal or a higher antigen dose.     

Rapid enantioseparation of 1-aminoindan by microchip electrophoresis with linear-imaging UV detection.

Chiral separations of 1-aminoindan (AI) by cyclodextrin electrokinetic chromatography (CDEKC) were investigated on microfluidic quartz chips. By using a microchip electrophoresis (MCE) instrument equipped with a linear-imaging UV detector, the separation process of the enantiomeric compounds was observed. When sulfated beta-cyclodextrin was employed as a chiral selector, the baseline separation of AI could be achieved within 1 min with a high repeatability. The relative standard deviation of the migration time was less than 6%. The fastest separation was achieved in 14 s, utilizing a separation length of only 6.1 mm. These results show that the MCE analysis employing a linear imaging UV detector has a significant potential for fast chiral analysis.     

Electromagnetic moments of the doubly closed shell ±1 nucleon nuclei and on-line nuclear polarization

Electromagnetic moments of doubly closed shell ±1 nucleon nuclei were studied. Recent technical developments of the β-NMR was shown that was applicable for the polarized β emitters. Also, the implication of those new moments were discussed especially on the nuclear interactions and non nucleonic degrees of freedom.     

An incremental theory of large strain and large displacement problems and its finite element formulation

Summary This paper is concerned with the development of an incremental finite'element theory for the large strain and the large displacement problems, referred to the current configuration of the body. Using the convected coordinate system which is embedded in the body, the incremental representations of strain and stress tensors and the energy relations are presented, and then the general procedure to construct the so-called element stiffness matrix in incremental form is considered. The finite element formulation is developed for a typical constitutive relation and it is shown that some correction matrices, some of which have been omitted in the previous works, are to be added to the element stiffness matrix. Finally the method to assemble the equations of the element to the global system is discussed and a simple finite element model satisfying the compatibility condition is presented.The finite element theory developed in this paper is able to be extended to the problems for the general thermodynamical process of a broad class of nonlinear materials.

---

Übersicht Mit Hilfe der Methode der finiten Elemente wird eineZuwachstheorie zurBehandlung von Problemen mit endlicher Verformung abgeleitet. Dabei wird ein im Körper eingebettetes, der momentanen Form angepaßtes Bezugssystem verwendet. Es werden Ausdrücke für die Energie sowie für die Änderungen der Spannungs- und Verformungs-Tensoren abgeleitet und es wird ein Verfahren zur Konstruktion der Steifigkeitsmatrix für ein Element angegeben. Ein typisches Stoffgesetz wird dabei zugrundegelegt. Dabei zeigt es sich, daß einige in früheren Arbeiten vernachlässigte Korrektur-Matrizen zu der Steifigkeits-Matrix des Elementes hinzugefügt werden müssen. Die Möglichkeiten der Zusammenfassung der für die Elemente geltenden Gleichungen zu einem globalen Gleichungssystem werden diskutiert und es wird ein den Verträglichkeitsbedingungen genügendes Elemente-Modell angegeben.Das angegebene Verfahren kann für allgemeine thermodynamische Prozesse in einer breiten Klasse nichtlinearer Materialien erweitert werden.

     

Unconventional Magnetic and Resistive Hysteresis in an Iodine‐Bonded Molecular Conductor

Simultaneous manipulation of both spin and charge is a crucial issue in magnetic conductors. We report on a strong correlation between magnetism and conductivity in the iodine‐bonded molecular conductor (DIETSe)₂FeBr₂Cl₂ [DIETSe=diiodo(ethylenedithio)tetraselenafulvalene], which is the first molecular conductor showing a large hysteresis in both magnetic moment and magnetoresistance associated with a spin‐flop transition. Utilizing a mixed‐anion approach and iodine bonding interactions, we tailored a molecular conductor with random exchange interactions exhibiting unforeseen physical properties.