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41.
Strontium aluminates are viewed as a promising persistent luminescent materials. There are many researches on strontium aluminates, including SrAl2O4, Sr4Al14O25. Between these two phases, Sr4Al14O25 shows much better properties than SrAl2O4. The traditional way to synthesize Sr4Al14O25 is the solid state reaction. However, it exists few problems, especially non-homogeneous product. As a result, there are two methods chosen to make homogeneous precursor. One is sol–gel method, the other is combustion with Urea as a fuel. Boric acid is added as a flux in both method. In this study, combustion process is found to be a better way for synthesizing Sr4Al14O25. We change the temperature, synthetic method. The samples are finely grinded and used for XRD analysis, photoluminescence measurement, and after-glow decay curve to figure out the optimizing luminescent parameters. 相似文献
42.
Regioselective Baeyer-Villiger lactonization of 2-substituted pyrrolidin-4-one. Synthesis of statine
Nine 2-substituted pyrrolidin-4-ones 4a-i were obtained via a series of functional group transformation of known prolinol 5 by facile six kinds of methodologies. The target structure of 1,3-amino alcohols 2a-i was constructed in the regioselective Baeyer-Villiger lactonization of ketones 4a-i and reduction of the resulting 4-substituted tetrahydro-1,3-oxazin-6-ones 3a-i. A new and straightforward synthesis of (3S,4S)-statine (6) has been established starting from trans-(2S,4R)-4-hydroxyproline (1). 相似文献
43.
Erlanson DA McDowell RS He MM Randal M Simmons RL Kung J Waight A Hansen SK 《Journal of the American Chemical Society》2003,125(19):5602-5603
Protein tyrosine phosphatases play important roles in many signaling cascades involved in human disease. The identification of druglike inhibitors for these targets is a major challenge, and the discovery of suitable phosphotyrosine (pY) mimetics remains one of the key difficulties. Here we describe an extension of tethering technology, "breakaway tethering", which is ideally suited for discovering such new chemical entities. The approach involves first irreversibly modifying a protein with an extender that contains both a masked thiol and a known pY mimetic. The extender is then cleaved to release the pY mimetic, unmasking the thiol. The resulting protein is screened against a library of disulfide-containing small molecule fragments; any molecules with inherent affinity for the pY binding site will preferentially form disulfides with the extender, allowing for their identification by mass spectrometry. The ability to start from a known substrate mimimizes perturbation of protein structure and increases the opportunity to probe the active site using tethering. We applied this approach to the anti-diabetic protein PTP1B to discover a pY mimetic which belongs to a new molecular class and which binds in a novel fashion. 相似文献
44.
Effect of conjugated linoleic acid immobilization on the hemocompatibility of cellulose acetate membrane 总被引:1,自引:0,他引:1
Conjugated linoleic acid (CLA) was covalently immobilized onto cellulose acetate (CA) membranes. The effects of CLA immobilization on the blood coagulation, platelet aggregation, and oxidative stress were evaluated using human blood. The resulting CLA grafting CA membranes were characterized with X-ray photoelectronic spectroscopy (XPS). The complete blood count (CBC) and coagulation time (CT) was evaluated in vitro for the hemocompatibility. Human serum albumin (HSA) and human plasma fibrinogen (HPF) was evaluated for the protein affinity. The production of reactive oxygen species (ROS) was measured by chemiluminescence (CL) method to evaluate the oxidative stress. The results showed that the CLA-immobilizing CA membrane could keep the CBC values more stable than unmodified CA membrane. The CLA-immobilized CA membranes also showed longer CT and less adsorption of plasma proteins. CLA-immobilized CA membrane could keep the CL counts of hydrogen peroxide and superoxide values more stable than unmodified CA membrane. These results suggest that a CLA-immobilized CA membrane could offer protection for patients against oxidative stress and would be helpful for reducing the dosage of anticoagulant during hemodialysis. 相似文献
45.
46.
The benzannulated enediynyl propargylic alcohol 8 was prepared from 1-bromo-2-iodobenzene by two consecutive Sonogashira cross-coupling reactions. The subsequent transformation to mesylate 9 followed by treatment with 4-substituted pyridines 10 then furnished the benzannulated enediynes 11. On exposure of 11 to triethylamine, the indeno-fused quinolizinium salts 15 were produced in quantitative yield. Presumably the reaction proceeded through a 1,3-prototropic rearrangement to form the benzannulated enyne-allenes 12, which then underwent either a concerted Diels-Alder reaction or a two-step process involving a Schmittel cyclization reaction to form biradical 13 followed by an intramolecular radical-radical coupling to afford 14. A subsequent prototropic rearrangement then produced 15. Similarly, 21a and 21b were produced from 19a and 19b, respectively. The use of the Sonogashira reaction for cross-coupling between 1-iodo-2-(phenylethynyl)benzene (7) and 1-(2-propynyl)-1H-imidazole (25) followed by treatment of the resulting adduct with potassium tert-butoxide gave the indeno-fused imidazo[1,2-a]pyridine 24 in 98% yield. Similarly, the indeno-fused pyrido[1,2-a]indole 32 and 4H-quinolizin-4-one 35 were obtained by starting from 7 for cross-coupling with 1-(2-propynyl)-1H-indole (30) and 1-(2-propynyl)-2(1H)-pyridinone (33), respectively, followed by treatment with potassium tert-butoxide. 相似文献
47.
Ming‐Yi Chen Jian‐Xun Wang Kung‐Tung Chen Bi‐Zhou Wen Wei‐Chieh Lin Chiing‐Chang Chen 《中国化学会会志》2012,59(2):170-175
Calcium carbide residue (CCR) was investigated in transesterification reaction of triglycerides to determine its viability as a solid catalyst for biodiesel synthesis. Literature survey showed that CCR has never been studied as a solid catalyst in the transesterification of triglyceride. The scope of the study includes the effects of CCR calcination temperature, calcination time, the alcohol/oil molar ratio, the catalyst amount (wt % of oil) and the reaction time. The relationship between chemical composition and catalytic activity of waste cement was also investigated. These CCR catalysts, thermally activated at 600 °C, can give rise to fatty acid methyl esters (FAME) purity higher than 99.5%, after 3 h of reaction, when oil/methanol molar ratio of 1/12 and 1 wt % of the catalyst were employed. Application of CCR as catalyst for biodiesel production in this study may not only provide a cost‐effective and environment friendly way of recycling CCR waste but also reduce hopefully the cost of biodiesel production. 相似文献
48.
Strachan JD Adler H Alling P Ancher C Anderson H Anderson JL Ashcroft D Barnes CW Barnes G Batha S Bell MG Bell R Bitter M Blanchard W Bretz NL Budny R Bush CE Camp R Caorlin M Cauffman S Chang Z Cheng CZ Collins J Coward G Darrow DS DeLooper J Duong H Dudek L Durst R Efthimion PC Ernst D Fisher R Fonck RJ Fredrickson E Fromm N Fu GY Furth HP Gentile C Gorelenkov N Grek B Grisham LR Hammett G Hanson GR Hawryluk RJ Heidbrink W Herrmann HW Hill KW Hosea J Hsuan H Janos A Jassby DL Jobes FC 《Physical review letters》1994,72(22):3526-3529
49.
Harihara Padhy Duryodhan Sahu Dhananjaya Patra Murali Krishna Pola Jen‐Hsien Huang Chih‐Wei Chu Kung‐Hwa Wei Hong‐Cheu Lin 《Journal of polymer science. Part A, Polymer chemistry》2011,49(15):3417-3425
Two β‐cyano‐thiophenevinylene‐based polymers containing cyclopentadithiophene ( CPDT‐CN ) and dithienosilole ( DTS‐CN ) units were synthesized via Stille coupling reaction with Pd(PPh3)4 as a catalyst. The effects of the bridged atoms (C and Si) and cyano‐vinylene groups on their thermal, optical, electrochemical, charge transporting, and photovoltaic properties were investigated. Both polymers possessed the highest occupied molecular orbital (HOMO) levels of about ?5.30 eV and the lowest unoccupied molecular orbital (LUMO) levels of about ?3.60 eV, and covered broad absorption ranges with narrow optical band gaps (ca. 1.6 eV). The bulk heterojunction polymer solar cell (PSC) devices containing an active layer of electron‐donor polymers ( CPDT‐CN and DTS‐CN ) blended with an electron‐acceptor, that is, [6,6]‐phenyl‐C61‐butyric acid methyl ester (PC61BM) or [6,6]‐phenyl‐C71‐butyric acid methyl ester (PC71BM), in different weight ratios were explored under 100 mW/cm2 of AM 1.5 white‐light illumination. The PSC device based on DTS‐CN: PC71BM (1:2 w/w) exhibited a best power conversion efficiency (PCE) value of 2.25% with Voc = 0.74 V, Jsc = 8.39 mA/cm2, and FF = 0.36. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011. 相似文献
50.
Yi‐Chun Kung Sheng‐Huei Hsiao 《Journal of polymer science. Part A, Polymer chemistry》2011,49(16):3475-3490
A series of novel aromatic polyamides with pyrenylamine in the backbone were prepared from a newly synthesized dicarboxylic acid monomer, N,N‐di(4‐carboxyphenyl)‐1‐aminopyrene, and various aromatic diamines via the phosphorylation polyamidation technique. These polyamides were readily soluble in many organic solvents and could be solution‐cast into tough and amorphous films. They had useful levels of thermal stability with glass‐transition temperatures in the range of 276–342 °C and 10% weight loss temperatures in excess of 500 °C. The dilute N‐methyl‐2‐pyrrolidone (NMP) solutions of these polymers exhibited fluorescence maxima around 455–540 nm with quantum yields up to 56.9%. The polyamides also showed remarkable solvatochromism of the emission spectra. Their films showed reversible electrochemical oxidation and reduction accompanied by strong color changes from colorless neutral state to purple oxidized state and to yellow reduced state. The polyamide 4g containing the pyrenylamine units in both diacid and diamine sides exhibited easily accessible p‐ and n‐doped states, together with multicolored electrochromic behaviors. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011 相似文献