High-throughput purification of combinatorial libraries I: a high-throughput purification system using an accelerated retention window approach

We have developed a high-throughput purification system to purify combinatorial libraries at a 50-100-mg scale with a throughput of 250 samples/instrument/day. We applied an accelerated retention window method to shorten the purification time and targeted one fraction per injection to simplify data tracking, lower QC workload, and simplify the postpurification processing. First, we determined the accurate retention time and peak height for all compounds using an eight-channel parallel LC/UV/MS system, and calculated the specific preparative HPLC conditions for individual compounds. The preparative HPLC conditions include the compound-specific gradient segment for individual compounds with a fixed gradient slope and the compound-specific UV or ELSD threshold for triggering a fraction collection device. A unique solvent composition or solvent strength was programmed for each compound in the preparative HPLC in order to elute all compounds at the same target time. Considering the possible deviation of the predicted retention time, a 1-min window around the target time was set to collect peaks above a threshold based on UV or ELSD detection. Dual column preparative instruments were used to maximize throughput. We have purified more than 500 000 druglike compounds using this system in the past 3 years. We report various components of this high-throughput purification system and some of our purification results.     

Thermodynamic and Equilibrium Composition Analysis of Using Iron Oxide as an Oxygen Carrier in Nonflame Combustion Technology

1. Introduction The utilization of fossil fuels causes serious neg- ative impacts on the environment and human life. There are many pollutants such as SOx, NOx and CO2 emission produced from the combustion of coal, oil and natural gas. It has been known for more than 100 years that CO2 is a greenhouse gas and that the release of CO2 from fossil fuel combustion may affect the climate of the earth. In the last years the concern over the aspects of an increased release of greenhouse gases has…     

四价锗与3, 4－二羟墓苯甲醛配合物的极谱研究

本文采用极谱法研究了Ge(Ⅳ)-3,4-二羟基苯甲醛(DHB)配合物的组成,条件稳定常数.并对该配合物的极谱波性质进行了研究.     

白术挥发油中苍术酮氧化反应的动力学

白术挥发油;苍术酮;动力学方程;活化能;反应机理     

Thermodynamic and Equilibrium Composition of Using Iron Oxide as an Oxygen Carrier Nonflame Combustion Technology Analysis in

本文介绍了一种新的燃烧体系--熔融盐循环热载体无烟燃烧技术。这种燃烧体系杜绝环境污染气体NOx和CO2的排放，可以实现真正零排放的目标。计算了以Fe2O3作为氧载体的无烟燃烧体系的热力学参数。用最小吉布斯自由能原则，分析了Fe2O3与CH4的平衡组成。分析表明，如果要想在产物中产生高纯度的CH4完全氧化产物CO2和H2O，Fe2O3与CH4必须达到高摩尔比，如果Fe2O3的量不足，就会产生较多的部分氧化产物如CO，H2甚至C     

ZrO2对合成二甲醚双功能催化剂表面结构及催化性能的影响

采用共沉淀沉积法制备了Cu基双功能催化剂，并进行了合成气一步法制取二甲醚实验．XRD、XPS以及BET表征结果表明，催化剂中ZrO2以无定形状态存在，且随着其含量的增加，Zr^4 逐渐溶进CuO晶格，两者之间的电子交换使得Cu^2 在活化过程中很难被彻底还原为Cu^0，而是以Cu^0/Cu^ 的形式共存．活性评价结果表明，Cu^ 离子表现出优异的CO转化率和DME选择性．同时，ZrO2的存在能有效调节催化剂表面的Cu／Zn摩尔比以及促进Cu元素在表面的富集，从而改善催化剂性能．     

镉—溴化物—罗丹明B高灵敏显色反应的研究：离心光度法测定镉

本研究了一个高灵敏的测定镉的方法，离心光度法，该体系络合物λｍａｘ＝５６０ｎｍ，表观摩尔吸系数ε５６０＝５．０６×１０＾８Ｌ．ｍｏｌ＾－１．ｃｍ＾－１，Ｃｄ＾２＋浓度０．１０×１０＾－２－１．０×１０＾－２μｇ／１０ｍＬ呈线性关系，本法已用于血清和水中痕量镉的测定，探讨了高灵敏的显色反应机理。     

有机镓、铟芳酰腙配合物的制备与结构表征

通过芳酰腙与三甲基镓或三甲基铟的反应,制备得到了七个有机镓或铟的镓芳酰腙配合物,在配合物中金属直接与芳酰腙的氧和烯胺氮成键,形成五元环状分子内配合物。对得到的化合物通过元素分析、红外光谱、质子核磁共振和质谱进行了结构表征。     

Carbon nanotube assisted synthesis of CeO2 nanotubes

CeO₂ nanotubes have been synthesized facilely using carbon nanotubes (CNTs) as templates by a liquid phase deposition method. The properties of the CeO₂ nanotubes were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectrum (XPS) as well as thermogravimetry and differential thermal analysis (TG-DTA). The obtained CeO₂ nanotubes with a polycrystalline face-centered cubic phase have a uniform diameter ranging from 40 to 50 nm. The CeO₂ nanotubes are composed of many tiny interconnected nanocrystallites of about 10 nm in size. The pretreatment of CNTs and calcination temperature were confirmed to be the crucial factors determining the formation of CeO₂ nanotubes. A possible formation mechanism has been suggested to explain the formation of CeO₂ nanotubes.     

液晶的激光拉曼光谱研究——Ⅰ.十九种液晶的固相激光拉曼光谱

本文报道联苯、联苯酯、单酯、双酯、Schiff碱和氧化偶氮苯型十九种液晶化合物的固相激光拉曼光谱,讨论了2300～400 cm~(-1)范围内基团的特征谱带归属以及光谱与结构之间的关系.