A Facile Synthesis of Fused Phosphorus-Heterocycle with Bioactivity via Lawesson's Reagent

A convenient one-pot synthesis of fused phosphorus-heterocycles with biological activity via the cyclization reactions of Lawesson's reagent with bifunctional substrates is reported.     

Interlayer shear strength of single crystalline graphite

Reported values(0.2 MPa-7.0 GPa) of the interlayer shear strength(ISS) of graphite are very dispersed.The main challenge to obtain a reliable value of the ISS using conventional measuring methods was the unavailability of sufficiently large single crystalline graphite.Here we present a novel experimental method to measure the ISS,and obtain the value as ～0.14 GPa.Our result can serve as an important basis for understanding mechanical behavior of graphite or graphene-based materials.     

Gd complexes of diethylenetriaminepentaacetic acid conjugates of low-molecular-weight chitosan oligosaccharide as a new liver-specific MRI contrast agent

This study was to describe the synthesis of complexes of gadolinium diethylenetriaminepentaacetic acid conjugates of low-molecular-weight chitosan oligosaccharide Gd-DTPA-CSn (n = 6, 8, 11) as a new class of contrast agent as well as its magnetic property in a pilot magnetic resonance imaging. The efficacy of the contrast agent was assessed by measuring the longitudinal relaxivity (r₁), FLASH imaging in phantoms in vitro and signal intensity in vivo of the rat abdominal axial imaging. The r₁ of Gd-DTPA-CS₁₁ was up to 11.65 mM^− 1·s^− 1, which was 3 times higher than that of the analogous MRI contrast agent Gd-DTPA in commercial use. In vivo MR images of rat obtained with Gd-DTPA-CS₁₁ showed strong signal enhancement in liver and the vessels of the liver parenchyma during the extended period of time. The present study suggests that the new synthesized gadolinium complexes can be used as a new class of practical liver-specific MRI contrast agent because of its superior performance compared with Gd-DTPA.     

不同尺寸的NdFeB稀土永磁体热退磁行为研究

针对不同类型及不同尺寸的两类NdFeB永磁体分别研究了它们随温度变化的热退磁行为。采用样品的整体剩余磁通来表征热退磁过程中磁体性能的变化。结果表明,Pc较小的永磁体温度稳定性较差,随温度的升高,样品的剩余磁通迅速衰减;Pc<<0.1的普通型永磁体,温度为100℃时样品的剩余磁通损失超过60%。高矫顽力型永磁体比普通型磁体具有更优越的温度稳定性和高温性能。温度升高主要导致磁体矫顽力降低,140℃时普通型磁体的矫顽力降低约80%,而高矫顽力型磁体的矫顽力只降低了约20%。     

Cu-catalyzed direct C–H amination of 2-alkylazaarenes with azodicarboxylates via nucleophilic addition

An efficient Cu-catalyzed C–H amination of 2-alkylazaarenes with azodicarboxylates has been developed through nucleophilic addition of sp³C–H bond to unsaturated nitrogen–nitrogen double bond. It provides an easy access to azaarene-containing hydrazines from simple and easily available starting materials.     

Synthesis and characterization of novel elastomeric poly(D,L-lactide urethane) maleate composites for bone tissue engineering

Here, we report the synthesis and characterization of a novel 4-arm poly(lactic acid urethane)-maleate (4PLAUMA) elastomer and its composites with nano-hydroxyapatite (nHA) as potential weight-bearing composite. The 4PLAUMA/nHA ratios of the composites were 1:3, 2:5, 1:2 and 1:1. FTIR and NMR characterization showed urethane and maleate units integrated into the PLA matrix. Energy dispersion and Auger electron spectroscopy confirmed homogeneous distribution of nHA in the polymer matrix. Maximum moduli and strength of the composites of 4PLAUMA/nHA, respectively, are 1973.31 ± 298.53 MPa and 78.10 ± 3.82 MPa for compression, 3630.46 ± 528.32 MPa and 6.23 ± 1.44 MPa for tension, 1810.42 ± 86.10 MPa and 13.00 ± 0.72 for bending, and 282.46 ± 24.91 MPa and 5.20 ± 0.85 MPa for torsion. The maximum tensile strains of the polymer and composites are in the range of 5–93%, and their maximum torsional strains vary from 0.26 to 0.90. The composites exhibited very slow degradation rates in aqueous solution, from approximately 50% mass remaining for the pure polymer to 75% mass remaining for composites with high nHA contents, after a period of 8 weeks. Increase in ceramic content increased mechanical properties, but decreased maximum strain, degradation rate, and swelling of the composites. Human bone marrow stem cells and human endothelial cells adhered and proliferated on 4PLAUMA films and degradation products of the composites showed little-to-no toxicity. These results demonstrate that novel 4-arm poly(lactic acid urethane)-maleate (4PLAUMA) elastomer and its nHA composites may have potential applications in regenerative medicine.