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51.
Couturier M Ménard F Ragan JA Riou M Dauphin E Andresen BM Ghosh A Dupont-Gaudet K Girardin M 《Organic letters》2004,6(11):1857-1860
Lewis-base-catalyzed cycloisomerization of bis(enones) to decalins has been demonstrated as an alternative to the traditional Lewis acid catalyzed Diels-Alder cycloaddition. In this process, a trialkylphosphine mediates both bond formation steps in two distinct catalytic cycles. The single-pot operation generates two carbon-carbon bonds and up to five contiguous stereocenters in one step, starting from achiral, aliphatic substrates; eight examples are provided. [reaction: see text] 相似文献
52.
Gilbert KM Skawinski WJ Misra M Paris KA Naik NH Buono RA Deutsch HM Venanzi CA 《Journal of computer-aided molecular design》2004,18(11):719-738
Summary Methylphenidate (MP) binds to the cocaine binding site on the dopamine transporter and inhibits reuptake of dopamine, but does not appear to have the same abuse potential as cocaine. This study, part of a comprehensive effort to identify a drug treatment for cocaine abuse, investigates the effect of choice of calculation technique and of solvent model on the conformational potential energy surface (PES) of MP and a rigid methylphenidate (RMP) analogue which exhibits the same dopamine transporter binding affinity as MP. Conformational analysis was carried out by the AM1 and AM1/SM5.4 semiempirical molecular orbital methods, a molecular mechanics method (Tripos force field with the dielectric set equal to that of vacuum or water) and the HF/6-31G* molecular orbital method in vacuum phase. Although all three methods differ somewhat in the local details of the PES, the general trends are the same for neutral and protonated MP. In vacuum phase, protonation has a distinctive effect in decreasing the regions of space available to the local conformational minima. Solvent has little effect on the PES of the neutral molecule and tends to stabilize the protonated species. The random search (RS) conformational analysis technique using the Tripos force field was found to be capable of locating the minima found by the molecular orbital methods using systematic grid search. This suggests that the RS/Tripos force field/vacuum phase protocol is a reasonable choice for locating the local minima of MP. However, the Tripos force field gave significantly larger phenyl ring rotational barriers than the molecular orbital methods for MP and RMP. For both the neutral and protonated cases, all three methods found the phenyl ring rotational barriers for the RMP conformers/invertamers (denoted as cte, tte, and cta) to be: cte, tte> MP > cta. Solvation has negligible effect on the phenyl ring rotational barrier of RMP. The B3LYP/6-31G* density functional method was used to calculate the phenyl ring rotational barrier for neutral MP and gave results very similar to those of the HF/6-31G* method. 相似文献
53.
Orrling K Nilsson P Gullberg M Larhed M 《Chemical communications (Cambridge, England)》2004,(7):790-791
This communication describes the development of a controlled microwave methodology for rapid milliliter-scale PCR. 相似文献
54.
Håkansson K Hudgins RR Marshall AG O'Hair RA 《Journal of the American Society for Mass Spectrometry》2003,14(1):23-41
We report electron capture dissociation (ECD) and infrared multiphoton dissociation (IRMPD) of doubly protonated and protonated/alkali metal ionized oligodeoxynucleotides. Mass spectra following ECD of the homodeoxynucleotides polydC, polydG, and polydA contain w or d "sequence" ions. For polydC and polydA, the observed fragments are even-electron ions, whereas radical w/d ions are observed for polydG. Base loss is seen for polydG and polydA but is a minor fragmentation pathway in ECD of polydC. We also observe fragment ions corresponding to w/d plus water in the spectra of polydC and d(GCATGC). Although the structure of these ions is not clear, they are suggested to proceed through a pentavalent phosphorane intermediate. The major fragment in ECD of d(GCATGC) is a d ion. Radical a- or z-type fragment ions are observed in most cases. IRMPD primarily results in base loss, but backbone fragmentation is also observed. IRMPD provides more sequence information than ECD, but the spectra are more complex due to extensive base and water losses. It is proposed that the smaller degree of sequence coverage in ECD, with fragmentation mostly occurring close to the ends of the molecules, is a consequence of a mechanism in which the electron is captured at a P=O bond, resulting in a negatively charged phosphate group. Consequently, at least two protons (or alkali metal cations) must be present to observe a w or d fragment ion, a requirement that is less likely for small fragments. 相似文献
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57.
Ilie-Radu Mitric Kristina P. Sendova Cary Chi-Liang Tsai 《Statistics & probability letters》2010,80(5-6):366-375
We consider a multi-layer compound Poisson surplus process perturbed by diffusion and examine the behaviour of the Gerber–Shiu discounted penalty function. We derive the general solution to a certain second order integro-differential equation. This permits us to provide explicit expressions for the Gerber–Shiu function depending on the current surplus level. The advantage of our proposed approach is that if the diffusion term converges to zero, the above-mentioned explicit expressions converge to those under the classical compound Poisson model, provided that the same initial conditions apply. This is subsequently illustrated by an extended example related to the probability of ultimate ruin. 相似文献
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Kristina Star?evi? Marijana Hranjec Dejana Cari? Grace Karminski-Zamola 《Monatshefte für Chemie / Chemical Monthly》2008,19(2):975-983
A series of novel substituted derivatives related to furyl-phenyl-acrylates and naphthofurans, was synthesized and characterized
by UV/Vis and fluorescence spectroscopy. Acyclic compounds can undergo photochemical dehydrocyclization by visible light irradiation
in order to obtain their cyclic derivatives. The interactions of the prepared compounds with calf thymus DNA was investigated by means of electronic absorption and fluorescence spectra. It is intriguing that addition of ct-DNA induced a fluorescence increase of acyclic derivatives, exactly the opposite of the strong fluorescence quenching observed
for cyclic derivatives 10 and 12. Compound 11 showed decreasing fluorescence intensity for lower concentrations of ct-DNA, while increasing of fluorescence is observed for high excess of added ct-DNA. 相似文献