Synthesis and antimicrobial activity of some novel benzofuran based 1,2,3-triazoles

In the present study, a series of novel {6-[(1H-1,2,3-triazol-4-yl)methoxy]-3-methylbenzofuran-2-yl}(phenyl)methanones (7a–7o) have been synthesized using click chemistry approach. The structures of all newly synthesized compounds were characterized by FT-IR, ¹H and ¹³C NMR, and MASS spectral data. Most of products demonstrated high antimicrobial activity.

     

Studies towards the stereoselective total synthesis of Gliomasolide A

The first synthetic approach towards the Gliomasolide A is described in 15 linear steps with 4% overall yield. The key steps in this approach are RCM protocol for the construction of 14-member macrolide, a Sharpless kinetic resolution, Keck and Brown’s allylations for the installation of desired stereocenters.     

A convergent approach towards the synthesis of the 2-alkyl-substituted tetrahydroquinoline alkaloid (−)-cuspareine

A convergent approach towards the synthesis of the 2-alkyl-substituted tetrahydroquinoline alkaloid (?)-cuspareine via enantiospecific construction of the (R)-benzyl 2-formyl-3,4-dihydroquinoline-1(2H)-carboxylate. We have achieved an efficient enantiospecific synthesis of (?)-cuspareine starting from known key starting materials. The reactions employed for individual transformations are simple and high yielding, and the strategy could potentially be easily extended.     

A simple efficient sequential one-pot intermolecular aza-Michael addition and intramolecular Buchwald–Hartwig α-arylation of amines: synthesis of functionalized tetrahydroisoquinolines

An efficient one-pot sequential intermolecular aza-Michael addition and Pd-catalyzed intramolecular Buchwald–Hartwig α-arylation of secondary amines have been investigated, for the synthesis of tetrahydroisoquinolines. This method is simple and furnished products in very good yield and also successfully applied for the synthesis of novel aza-spirotricylcic ethers.     

An eco-safe approach to benzopyranopyrimidines and 4H-chromenes in ionic liquid at room temperature

An environmentally benign, ionic liquid promoted multicomponent protocol to benzopyrano(2,3-d)pyrimidines and 4H-chromenes has been developed at room temperature. Results of the reaction depend on the nature of the nucleophile used in the reaction. Secondary amines result in the formation of benzopyrano(2,3-d)pyrimidines, whereas thiols give rise to 4H-chromenes under the same set of reaction conditions.     

New Chromogenic Spray Reagent for Detection and Identification of Carbosulfan

JPC – Journal of Planar Chromatography – Modern TLC - A new chromogenic spray reagent has been used for detection and identification of carbosulfan in HPTLC. Alkaline hydrolysis of...     

Molecular conformation and liquid structure of 2-propanol through neutron diffraction

The neutron diffraction data analysis of deuterated liquid 2-propanol at room temperature to define its molecular conformation is presented. 2-Propanol being a large molecule with twelve atomic sites, the conformation analysis is tricky and an improved method of data analysis is given. The intermolecular structural correlations, i.e., hydrogen-bonded liquid structure, can be modelled accurately to extract the nature of the average hydrogen-bonded molecular association in liquid state at room temperature. Like other alcohols these are mostly hexamer ring chain (HRC) clusters. The cluster analysis of recent X-ray data available in the literature also support the same liquid structure.