全文获取类型
收费全文 | 9248篇 |
免费 | 166篇 |
国内免费 | 46篇 |
专业分类
化学 | 5973篇 |
晶体学 | 84篇 |
力学 | 292篇 |
数学 | 1677篇 |
物理学 | 1434篇 |
出版年
2021年 | 97篇 |
2020年 | 94篇 |
2019年 | 79篇 |
2018年 | 70篇 |
2017年 | 63篇 |
2016年 | 143篇 |
2015年 | 134篇 |
2014年 | 154篇 |
2013年 | 519篇 |
2012年 | 371篇 |
2011年 | 478篇 |
2010年 | 264篇 |
2009年 | 239篇 |
2008年 | 480篇 |
2007年 | 445篇 |
2006年 | 441篇 |
2005年 | 433篇 |
2004年 | 341篇 |
2003年 | 326篇 |
2002年 | 354篇 |
2001年 | 148篇 |
2000年 | 134篇 |
1999年 | 102篇 |
1998年 | 95篇 |
1997年 | 118篇 |
1996年 | 147篇 |
1995年 | 87篇 |
1994年 | 106篇 |
1993年 | 110篇 |
1992年 | 111篇 |
1991年 | 105篇 |
1990年 | 101篇 |
1989年 | 83篇 |
1988年 | 94篇 |
1987年 | 95篇 |
1986年 | 72篇 |
1985年 | 153篇 |
1984年 | 147篇 |
1983年 | 121篇 |
1982年 | 136篇 |
1981年 | 152篇 |
1980年 | 149篇 |
1979年 | 125篇 |
1978年 | 132篇 |
1977年 | 127篇 |
1976年 | 117篇 |
1975年 | 104篇 |
1974年 | 106篇 |
1973年 | 105篇 |
1972年 | 65篇 |
排序方式: 共有9460条查询结果,搜索用时 0 毫秒
101.
Juglomycin A has been synthesized in four steps from 5-methoxy-1-naphthol. 相似文献
102.
Studies of the extraction of thallum(l) from aqueous solution in the absence and presence of aqueous complexing agents into chloroform containing 2-mercaptobenzothiazole are described. Fluoride, chloride, bromide, iodide, thiocyanair, cyanide, and sulfate were employed as aqueous complexing agents. A number of the participating species were identified and association constants are estimated. 相似文献
103.
Wei ZL Sakamuri S Petukhov PA George C Lewin NE Blumberg PM Kozikowski AP 《Organic letters》2002,4(13):2169-2172
[structures: see text] Both (2S,5R,6R)- and (2S,5R,6S)-6-hydroxy-8-(1-decynyl)benzolactam-V8 were designed and synthesized as PKC modulators. Biological assays reveal the (6R)-ligand to be 20-fold more potent than its (6S)-counterpart in binding to PKC alpha. 相似文献
104.
105.
Jaan A. Pesti Jill A. Downard Mark D. Lauritsen Goss S. Kauffman Walter M. Bryant George F. Huhn John F. Arnett Robert E. Yule James Segretario Kimberly A. Nelson Edward F. Gorko Gary O. Page Lisa M. Lloyd Richard E. Olson Christopher S. Bamum Joseph J. Mrowca 《Journal of heterocyclic chemistry》1998,35(1):249-255
The methanesulfonates of (α-(4-chlorophenyl)-α-[1-(2-chlorophenyl)ethenyl]-1H-1,2,4-triazole-1-ethanol and α-[1-(2-chlorophenyl)ethenyl]-α-(2,4-difluorophenyl)-1H-1,2,4-triazole-1-ethanol ( 1a, b ) are orally effective α-styryl carbinol derivatives developed for the treatment and prevention of systemic fungal infections. Practical new processes amenable for the large-scale production of these compounds are described. Of note is the selection of dichlorostyrene as a convenient precursor of the styryl portion, modification of a sensitive Grignard addition into a realistic preparative reaction and the use of 1,2,4-triazole simultaneously as a base transfer agent and nucleophile. 相似文献
106.
Bendazzoli Gianni L. Raimondi Mario Garetz Bruce A. George Thomas F. Morokuma Keiji 《Theoretical chemistry accounts》1977,44(4):341-350
Semiclassical calculations are carried out by two methods for the problem of collision-induced predissociation of electronically excited I2. The first method is that of surface-hopping with the Landau-Zener model. The second method is similar to surface-hopping, except that analytic continuation of the adiabatic potential energy surfaces replaces the Landau-Zener model. Results of the calculations by the two methods compare favorably with each other and with experiment. The possible advantages of the second method are discussed.Camille and Henry Dreyfus Teacher-Scholar, Alfred P. Sloan Research Fellow. 相似文献
107.
James W. Schweitert George B. Butler 《Journal of polymer science. Part A, Polymer chemistry》1978,16(6):1359-1365
The monomer series, o-, m-, and p-(2-vinyloxyethoxy)-β-nitrostyrenes, was studied. All three monomers were selectively polymerized through the electron-donating vinyloxy group via cationic initiation. The linear polymers from the meta and para isomers containing the electron-accepting nitrovinyl group were readily crosslinked via anionic initiation. The polymer derived from the ortho isomer was not crosslinked by this mechanism, an observation in accord with results previously reported from these laboratories in which it was shown that all o-substituted-β-nitrostyrenes having ortho substituents larger than fluorine exhibited a sterically inhibited propagation step. The meta and para isomers of this series were selectively polymerized through the electron-accepting nitrovinyl group via anionic initiation. Because of the fact that the resulting polymers were soluble only in highly polar solvents, subsequent crosslinking of these polymers via cationic initiation could not be accomplished. However, these polymers showed strong tendencies to undergo crosslinking upon long exposure to air. Because of the sterically induced ortho effect referred to above, no significant polymerization occurred in the case of the ortho isomer of this series via anionic initiation. However, it was shown in this case that initiation via the anion was rapid, and that the slow step was propagation. 相似文献
108.
Edie M. Rasmussen Peter Willett Terence Wilson Gordon A. Manson George A. Wilson 《Analytica chimica acta》1990
The use of two types of parallel computer hardware for increasing the efficiency of processing in chemical structure data bases is discussed. The distributed array processor can be used for the clustering of 2-D chemical structure data bases by using the Jarvis—Patrick clustering method and for the ranking of output in an experimental system for substructure searching in the 3-D macromolecules in the Protein Data Bank. The Inmos transputer can be used in the construction of PC-based systems for 2-D substructure searching and in the identification of the maximal substructures common to pairs of 3-D molecules. 相似文献
109.
(3-Mercaptopropyl)trimethoxysilane (MTS) forms a unique film on a platinum substrate by self-assembly and sol-gel cross-linking. The gelating and drying states of the self-assembled MTS sol-gel films were probed by use of electrochemical and spectroscopic methods. The thiol moiety was the only active group within the sol-gel network. Gold nanoparticles were employed to detect the availability of the thiol group and their interaction further indicated the physicochemical states of the sol-gel inner structure. It was found that the thiol groups in the open porous MTS aerogel matrix were accessible to the gold nanoparticles while thiol groups in the compact MTS xerogel network were not accessible to the gold nanoparticles. The characteristics of the sol-gel matrix change with time because of its own irreversible gelating and drying process. The present work provides direct evidence of gold nanoparticle binding with thiol groups within the sol-gel structures and explains the different permeability of "aerogel" and "xerogel" films of MTS on the basis of electrochemical and spectroscopic results. Two endogenous species, hydrogen peroxide and ascorbic acid, were used to test the permeability of the self-assembled sol-gel film in different states. The MTS xerogel film on the platinum electrode was extremely selective against ascorbic acid while maintaining high sensitivity to hydrogen peroxide in contrast to the relatively high permeability of ascorbic acid in the MTS aerogel film. This study showed the potential of the MTS sol-gel film as a nanoporous material in biosensor development. 相似文献
110.
Cheng A Diller DJ Dixon SL Egan WJ Lauri G Merz KM 《Journal of computational chemistry》2002,23(1):172-183
Very large data sets of molecules screened against a broad range of targets have become available due to the advent of combinatorial chemistry. This information has led to the realization that ADME (absorption, distribution, metabolism, and excretion) and toxicity issues are important to consider prior to library synthesis. Furthermore, these large data sets provide a unique and important source of information regarding what types of molecular shapes may interact with specific receptor or target classes. Thus, the requirement for rapid and accurate data mining tools became paramount. To address these issues Pharmacopeia, Inc. formed a computational research group, The Center for Informatics and Drug Discovery (CIDD).* In this review we cover the work done by this group to address both in silico ADME modeling and data mining issues faced by Pharmacopeia because of the availability of a large and diverse collection (over 6 million discrete compounds) of drug-like molecules. In particular, in the data mining arena we discuss rapid docking tools and how we employ them, and we describe a novel data mining tool based on a ID representation of a molecule followed by a molecular sequence alignment step. For the ADME area we discuss the development and application of absorption, blood-brain barrier (BBB) and solubility models. Finally, we summarize the impact the tools and approaches might have on the drug discovery process. 相似文献