Visualization of Real‐Time Degradation of pH‐Responsive Polyglycerol Nanogels via Atomic Force Microscopy

Polyglycerol nanogels (nPG) have a huge impact in biomedical applications as drug deliverer due to their high biocompability. For such nPG nanogels, particle degradation is widely used as drug delivery method. The knowledge of this degradation process is limited up to date. In this communication, a real time visualization of such a degradation process is presented for pH‐responsive nPG nanogels via atomic force microscopy (AFM) under ambient and in liquid conditions. The particle height plays a major role in the degradation process and decays exponentially in the beginning of this process. The particle width increases during the process indicating a “decross‐linking” step of the particles into their starting monomers. Measurements under ambient conditions confirm this assumption and provide further insight in the “decross‐linking” step of the nanogels into individual dendritic particles. The present work gives a detailed insight in the particle degradation process, which is essential for further progress for the development of new drug delivery systems.

     

Scanning of silicon wafers in contact with aqueous CTAB solutions below the CMC

Hydrophilic silicon wafers are studied against aqueous solutions of hexadecyl trimethyl ammonium bromide (CTAB) at concentrations between 0.05 mM up to 1 mM (CMC). AFM studies show that nanobubbles are formed at concentrations up to 0.4 mM. From 0.5 mM upward, no bubbles could be detected. This is interpreted as the formation of hydrophobic domains of surfactant aggregates, becoming hydrophilic at about 0.5 mM. The high contact angle of the nanobubbles (140-150° through water) indicates that the nanobubbles are located on the surfactant domains. A combined imaging and colloidal probe AFM study serves to highlight the surfactant patches adsorbed at the surface via nanobubbles. The nanobubbles have a diameter between 30 and 60 nm (after tip deconvolution), depending on the surfactant concentration. This corresponds to a Laplace pressure of about 30 atm. The presence of the nanobubbles is correlated with force measurements between a silica probe and a silicon wafer surface. The study is a contribution to the better understanding of the short-range attraction between hydrophilic surfaces exposed to a surfactant solution.     

Quantized ν = 5/2 state in a two-subband quantum hall system

The evolution of the fractional quantum Hall state at filling 5/2 is studied in density tunable two-dimensional electron systems formed in wide wells in which it is possible to induce a transition from single- to two-subband occupancy. In 80 and 60 nm wells, the quantum Hall state at 5/2 filling of the lowest subband is observed even when the second subband is occupied. In a 50 nm well, the 5/2 state vanishes upon second subband population. We attribute this distinct behavior to the width dependence of the capacitive energy for intersubband charge transfer and of the overlap of the subband probability densities.     

Cyclotron resonance in a two-dimensional electron system with self-organized antidots

Experimental data are reported on studying cyclotron resonance in a two-dimensional electron system with an artificial random scattering potential generated by an array of self-organized AlInAs quantum islands formed in the plane of an AlGaAs/GaAs heterojunction. A sharp narrowing of the cyclotron resonance line is observed as the magnetic field increases, which is explained by the specific features of carrier scattering in this potential. The results obtained point to the formation of a strongly correlated electron state in strong magnetic fields at carrier concentrations smaller than the concentration of antidots.     

Magnetoplasmon replica in the recombination radiation spectra of a quasi-two-dimensional electron gas in GaAs/AlGaAs quantum wells

The radiative recombination spectra of two-dimensional electrons with free photoexcited holes are investigated for a wide variety of GaAs/ AlGaAs quantum wells, with different thicknesses and electron densities. It is found that for certain, close to integral, filling factors an intense line corresponding to an Auger process — radiative recombination with the emission of an additional magnetoplasmon — appears in the luminescence spectrum. The new line is shifted to lower energies with respect to the zero Landau level, and the magnetic field dependence of the energy splitting between these lines agrees with the theoretical concepts of the dispersion of magnetoplasmon excitations. This makes it possible to estimate the magnetoplasmon energy at the roton minimum. Pis’ma Zh. éksp. Teor. Fiz. 66, No. 8, 539–544 (25 October 1997)     

Indirect excitons and double electron-hole layers in a wide single GaAs/AlGaAs quantum well in a strong electric field

The recombination spectra of indirect excitons and double electron-hole layers in a wide single quantum well in an electric field are studied. It is found that electrons and holes in the wide well become spatially separated in a sufficiently strong electric field. This leads to a substantial reorganization of the radiative recombination spectrum and to a significant increase in the carrier lifetime. It is shown that the total charge of the electron-hole system can be changed by varying the photoexcitation frequency and the applied electric field, thus passing from the neutral case of indirect excitons to the case of charged double electron-hole layers. The concentration of excess carriers in the well is measured as a function of the electric field strength. The behavior of the excited states of indirect heavy-hole and light-hole excitions is studied for a neutral excitonic system in a strong electric field. It is shown that the electric-field dependences allow the excited states of indirect excitons with a light hole to be distinguished from the excited states with a heavy hole.