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991.
Schade D Kotthaus J Klein N Kotthaus J Clement B 《Organic & biomolecular chemistry》2011,9(14):5249-5259
N(ω)-Hydroxy-L-arginine (NOHA)--the physiological nitric oxide precursor--is the intermediate of NO synthase (NOS) catalysis. Besides the important fact of releasing NO mainly at the NOS-side of action, NOHA also represents a potent inhibitor of arginases, making it an ideal therapeutic tool to treat cardiovascular diseases that are associated with endothelial dysfunction. Here, we describe an approach to impart NOHA drug-like properties, particularly by wrapping up the chemically and metabolically instable N-hydroxyguanidine moiety with different prodrug groups. We present synthetic routes that deliver several more or less highly substituted NOHA derivatives in excellent yields. Versatile prodrug strategies were realized, including novel concepts of bioactivation. Prodrug candidates were primarily investigated regarding their hydrolytic and oxidative stabilities. Within the scope of this work, we essentially present the first prodrug approaches for an interesting pharmacophoric moiety, i.e., N-hydroxyguanidine. 相似文献
992.
Francisco C. C. Arantes Antonio C. Moro Iolanda S. Klein Cristiana da Silva Adelino V. G. Netto Antonio E. Mauro Vânia M. Nogueira 《Journal of Thermal Analysis and Calorimetry》2011,106(2):379-383
The synthesis, spectroscopic characterization, and thermal analysis of the compounds [Pd(X)2(mtu)(PPh3)] (X = Cl− (1), SCN− (2); mtu = N-methylthiourea; PPh3 = triphenylphosphine) and [Pd(X)2(phtu)(PPh3)] (X = Cl− (3), SCN− (4); phtu = N-phenylthiourea) are described. The thermal decomposition of the compounds occurs in two, three, or four stages and the final
decomposition products were identified as Pd0 by X-ray powder diffraction. The thermal stability order of the complexes is 4 > 3>2 > 1. 相似文献
993.
994.
Snelders DJ van Koten G Klein Gebbink RJ 《Chemistry (Weinheim an der Bergstrasse, Germany)》2011,17(1):42-57
The effects of introducing ionic functionalities in phosphine ligands on the coordination chemistry of these ligands and the catalytic behavior of the corresponding metal complexes are reviewed. The steric and electronic consequences of such functionalizations are discussed. Apart from these steric and electronic effects, the presence of charged groups often leads to additional, supramolecular interactions that occur in the second coordination sphere of the metal complex, such as intramolecular, interligand hydrogen bonding and Coulombic repulsion. These interactions can significantly alter the behavior of the phosphine ligand in question. Such effects have been observed in phosphine-metal association/dissociation equilibria, ligand substitution reactions, and stereoisomerism in phosphine-metal complexes. By drawing general conclusions, this review offers an insight into the coordination and catalytic behavior of phosphine ligands containing ionic functionalities and their corresponding metal complexes. 相似文献
995.
Naumann I Klein BC Bartel SJ Darsow KH Buchholz R Lange HA 《Rapid communications in mass spectrometry : RCM》2011,25(17):2517-2523
The pharmaceutical industry is interested in identifying novel target compounds. Due to their versatile pharmacological activities (e.g. antiviral, anti-carcinogen and immunosuppressive) sulfoquinovosyldiacylglycerides (SQDGs) are potential drug candidates. The present publication deals with the purification and structural characterization of SQDGs from three different strains of Phaeodactylum tricornutum. Besides detection of SQDGs (sn-1: C16:1/sn-2: C16:0 and sn-1: C20:5/sn-2: C16:0), two novel 2'-O-acylsulfoquinovosyldiacylglyerides (Ac-SQDGs, sn-1: C16:0/ sn-2: C16:0/2' C20:5 and sn-1: C20:5/sn-2: C16:0/2' C20:5) were identified by using matrix-assisted laser desorption/ionization (MALDI) QTrap time-of-flight (ToF) hybrid mass spectrometry (MS) with multistage MS(n). The analytical method enables the sn-position verification of fatty acids (MS(2)) as well as the confirmation of the regioposition of eicospentanoic acid at the sulfoquinovose (MS(3)). 相似文献
996.
Goldberg JM Wissner RF Klein AM Petersson EJ 《Chemical communications (Cambridge, England)》2012,48(10):1550-1552
Thioamides quench tryptophan and tyrosine fluorescence in a distance-dependent manner and thus can be used to monitor the binding of thioamide-containing peptides to proteins. Since thioamide analogs of the natural amino acids can be synthetically incorporated into peptides, they can function as minimally-perturbing probes of protein/peptide interactions. 相似文献
997.
Axel Klein Katharina Butsch Sait ElmasChristian Biewer Dominikus Heift Sara NitscheIrene Schlipf Helmut Bertagnolli 《Polyhedron》2012,31(1):649-656
The oxido-pincer ligand pydotH2 (2,6-bis(1-hydroxy-1-o-tolyl-ethyl-η2O,O′)pyridine) forms two different CuII containing complexes when prepared from anhydrous CuCl2. A combination of EPR spectroscopy and EXAFS allowed to structurally characterise the light-green dimer of the formula [(pydotH2)CuCl(μ-Cl)2ClCu(pydotH2)] and the penta-coordinate olive-green monomer [(pydotH2)CuCl2]. The molecular entities imply that the ligand remains protonated upon coordination. When dissolved in DMF both compounds form monomeric species [(pydotH2)CuCl2(DMF)] which could be characterised in detail by EPR, UV-Vis/NIR spectroscopy and electrochemical measurements. The assignments were supported by comparison with CuII complexes of the related ligands 2,6-bis(hydroxymethyl)pyridine (pydimH2) and 2,6-bis(1-hydroxy-1-methyl)pyridine (pydipH2). 相似文献
998.
From solid state reactions of Ag2O, HgO, and Sb2O3 at high temperatures under elevated oxygen pressures a new silver mercury antimonate, Ag5HgSbO6, has been obtained. According to a single crystal structure determination Ag5HgSbO6 crystallizes in space group P$\bar{3}$ 1c (no. 163) with a = 5.9263(4), c = 12.3023(7) Å, V = 374.18(4) Å3, Z = 2, 498 independent reflections, R1 = 0.030, wR2 = 0.059 (I ≥ 2 σ (I). Ag5HgSbO6 consists of HgSbO6 layers, analogous to BiI3, which are separated by Kagome nets formed by Ag+ ions. Perpendicular to these layers and along the c axis linear strings of Ag+ ions run through the large voids of the layers. Accordingly, Ag5HgSbO6 adopts the Ag5Pb2O6 type of structure where the lead positions are occupied by mercury and antimony alternatingly. The finding of mercury in octahedral coordination, particularly besides the lower charged Ag+ cations in linear coordination, which is also highly preferred by Hg2+ ions, is rather unexpected. Ag5HgSbO6 starts to decompose at 450 °C and, in contrast to subvalent and metallic Ag5Pb2O6, the new compound is charge balanced and semiconducting (ρ = 5.7 Ωcm at ambient temperature, Ea = 0.047 eV). 相似文献
999.
We study Markovian stochastic motion on a graph with finite number of nodes and adiabatically periodically driven transition rates. We show that, under general conditions, the quantized currents that appear at low temperatures are a manifestation of topological invariants in the counting statistics of currents. This observation provides an approach for classification of topological properties of the counting statistics, as well as for extensions of the phenomenon of the robust quantization of currents at low temperatures to the properties of the counting statistics which persist to finite temperatures. 相似文献
1000.
Klein JM Clegg JK Saggiomo V Reck L Lüning U Sanders JK 《Dalton transactions (Cambridge, England : 2003)》2012,41(13):3780-3786
Six new lanthanide complexes of two 44-membered macrocycles have been prepared and characterised in solution. An analysis of the conformations of the free macrocycles and their lanthanide complexes both in solution (2D NMR) and in solid state (X-ray crystallography) demonstrate that the complexation induces changes in folding of the macrocycles. 相似文献