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11.
Summary 2-(2-Pyridyl)-1, 3-propanediol was converted into the diacetate, which was then condensed with phthalimide. The product was hydrolyzed with hydrochloric acid to give 2-(2-pyridyl)-1, 3-diaminopropane. The free amine gave 12 complexes with copper(II), nickel(II), and cobalt(III), which were characterized spectroscopically and magnetically. Features of the amine as a ligand are discussed. A few related complexes were also studied. 相似文献
12.
Onoda M Tokuyama H Uchiyama S Mawatari K Santa T Kaneko K Imai K Nakagomi K 《Chemical communications (Cambridge, England)》2005,(14):1848-1850
Strong fluorescence signals were observed after the reaction of novel reagents with hydroperoxides. 相似文献
13.
Methyl-p-benzoquinone (MQ) gives a single polarographic wave in methyl cellosolve media containing perchlorate as supporting electrolyte, but a prewave corresponding to the reaction Q + 2HA + 2e ái H2Q + 2A-, is found when an acid is added. The height of the prewave is proportional to the concentration of added acid. Traces (ca. 0.2%) of free perchloric acid can be determined in crude lithium perchlorate.The half-wave potential of the prewave depends on the pKa value of the acid; if the dissociation constants of acids differ sufficiently, two prewaves are found and each acid species can be determined simultaneously. This method was applied to the MQ-HClO4-CH3COOH, MQ-CCl3COOH-CH3COOH and MQ-CHCl2COOH- CH3COOH systems. 相似文献
14.
Kiryu S Inoue Y Watanabe M Izawa K Shimada M Tojo A Yoshikawa K Ohtomo K 《Magnetic resonance imaging》2009,27(1):101-107
We investigated the characteristics of gadoxetate disodium (Gd-EOB-DTPA) as a contrast agent for magnetic resonance imaging of the mouse liver. Mice were imaged sequentially under isoflurane anesthesia using a T1-weighted, three-dimensional fast low-angle shot (3D FLASH) sequence after an intravenous injection of Gd-EOB-DTPA or gadobenate dimeglumine (Gd-BOPTA), and the time course of the contrast effect was examined. The time course of the contrast effect of Gd-EOB-DTPA was also assessed after intravenous injection under pentobarbital anesthesia and after subcutaneous injection while awake or under isoflurane or pentobarbital anesthesia. Moreover, different doses of Gd-EOB-DTPA or Gd-BOPTA were injected subcutaneously into conscious mice, and the clarity of the liver border was evaluated visually. Intravenous injection under isoflurane anesthesia caused rapid contrast enhancement in the liver with both Gd-EOB-DTPA and Gd-BOPTA, and the contrast effect was 41% stronger with Gd-EOB-DTPA. Subcutaneous injection of Gd-EOB-DTPA caused delayed but favorable contrast enhancement in the liver. Washout of Gd-EOB-DTPA was faster in mice injected while awake than in those injected under anesthesia. After intravenous injection, washout was faster under pentobarbital anesthesia than under isoflurane anesthesia. The peak liver contrast was 11% and 18% stronger under pentobarbital anesthesia than under isoflurane anesthesia, after intravenous and subcutaneous injections, respectively. Subcutaneous injection of Gd-EOB-DTPA or Gd-BOPTA caused dose-dependent contrast effects in the liver. At a given dose, the contrast effect tended to be stronger and liver demarcation tended to be clearer with Gd-EOB-DTPA than with Gd-BOPTA. In conclusion, intravenous or subcutaneous injection of Gd-EOB-DTPA produces a favorable contrast effects in the mouse liver, indicating its potential in investigating mouse models of liver diseases. The contrast effects vary between conscious mice and anesthetized mice and among anesthetic agents used. 相似文献
15.
The reactions of N‐([1]benzofuro[3,2‐d]pyrimidin‐4‐yl)formamidines with hydroxylamine hydrochloride gave rearranged cyclization products via ring cleavage of the pyrimidine component accompanied by a ring closure of the 1,2,4‐oxadiazole to give N‐[2‐([1,2,4]oxadiazol‐5‐yl)[1]benzofuran‐3‐yl)formamide oximes. N‐([1]Benzothieno[3,2‐d]pyrimidin‐4‐yl)formamidines and N‐(pyrido[2,3‐d]pyrimidin‐4‐yl)formamidines with hydroxylamine hydrochloride gave similar results. 相似文献
16.
The redox and adsorption behaviour of some redox coenzymes involved in an electron-transport chain, i.e. ubiquinone-10 (CoQ), flavocoenzymes [flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)] and nicotinamide adenine dinucleotide (NAD+), has been studied at a gold electrode by cyclic voltammetry and specular reflectivity measurement. All the coenzymes investigated were found to participate in electron transport in adsorbed states on the electrode surface. Adsorbed CoQ and flavocoenzymes are reduced and the resulting products remain adsorbed at the surface. Contrary to them, adsorbed NAD+ is reduced and then desorbed immediately. Possible models for the surface orientation of adsorbed molecules were proposed based on the experimental data.Some analogies can be noted between the interfacial behaviour of these coenzymes at the electrode and that in mitochondria. 相似文献
17.
Kimura M Lehmann K Gopalan-Kriczky P Lotlikar PD 《Experimental & molecular medicine》2004,36(4):351-357
Effects of diets on hepatic aflatoxin B1 (AFB1)- DNA binding and AFB1-induced glutathione S- transferase placental (GST-P) form positive hepatic foci have been examined in young male Fischer rats. Animals were fed either AIN-76A or Purina Chow (PC) diet for 1 wk before AFB1- DNA binding studies in vivo and in vitro. Animals were injected i.p. with AFB1 (1 mug/kg body wt) and 3 days later were given either AIN-76A or PC diet with or without 0.1% phenobarbital (PB) in their drinking water. All animals were sacrificed 10 wks after AFB1 dosing for analysis of AFB1-induced GST-P positive hepatic foci by immunochemistry. Two h after i.p. injection of AFB1, hepatic AFB1-DNA binding in AIN-76A fed rats was twice as much as those in PC fed animals without affecting GSH levels. There was no significant effect of diet on either cytochrome P-450 content, GSH levels or microsomal cytochrome P-450 mediated AFB1-DNA binding to exogenous DNA. There was a 40% increase in cytosolic GSH S-transferase activity with 1-chloro-2,4-dinitrobenzene as a substrate in PC fed animals compared to those given AIN- 76A diet. The number and area of AFB1-induced GST-P positive hepatic foci were twice and fivefold as much in AIN-76A fed compared to those in PC fed rats. The number of AFB1-induced GST-P positive foci was increased 5-10 fold in the presence of PB in both groups. In summary, the present data indicate that feeding of PC diet compared to AIN-76A diet inhibits the initiation phase whereas AIN-76A stimulates the promotion phase of AFB1 hepatocarcinogenesis in rats by inhibiting AFB1-DNA binding and increasing AFB1-induced hepatic foci respectively. 相似文献
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20.
Takane Uchida Shigeharu Tsubokawa Kiyoko Harihara Kiyoshi Matsumoto 《Journal of heterocyclic chemistry》1978,15(8):1303-1307
1,3-Dipolar cycloaddition reactions of anhydro-5-hydroxyoxazolium hydroxide 3 generated from 2-piperidinecarboxylic acid and acetic anhydride, with dimethyl and diethyl acetylene-dicarboxylates, dibenzoylacetylene, p-benzoquinone, and 1,4-naphthoquinone gave the corresponding tetrahydroindolizines. In the case of the reaction with p-benzoquinone, the dihydroindolizine 12 was also formed. The primary N-bridged lactone intermediate 4 was isolated from the reaction of 2 with dibenzoylacetylene. Several attempted conversions of these tetrahydroindolizines into the corresponding aromatic indolizines were fruitless. 相似文献