Optimized and validated initial-rate method for the determination of perindopril erbumine in tablets

A simple and sensitive kinetic spectrophotometric method for the determination of perindopril in pharmaceutical preparations is described. The method is based on the interaction of drug with 1-chloro-2,4-dinitrobenzene (CDNB) in dimethylsulfoxide (DMSO) at 40+/-1 degrees C. The reaction is followed spectrophotometrically by measuring the rate of change of the absorbance at 420 nm. Under the optimized experimental conditions, the calibration curve showed a linear relationship over the concentration range of 20-140 microg/ml. The activation parameter such as E(a), deltaH*, deltaS* and deltaG* for this reaction were calculated and found to be 27.31 kJ/mol, 24.69 kJ/mol, -138.84 J/K/mol and 61.50 kJ/mol, respectively. The method has been successfully applied to the determination of perindopril in commercial dosage forms. Statistical comparison of the results with the Abdellatef's spectrophotometric method shows excellent agreement and indicates no significant difference between the methods compared in terms of accuracy and precision.     

Interaction of glycine with cationic, anionic, and nonionic surfactants at different temperatures: a volumetric, viscometric, refractive index, conductometric, and fluorescence probe study

A number of thermodynamic parameters viz. apparent molar volumes, ϕ _v , partial molar volumes, , transfer volumes, , Falkenhagen coefficients, A, Jones–Dole coefficients, B, free energies per mole of solute, , and per mole of solvent, , molar refraction, R _D , and limiting molar conductivity, , have been calculated by using the experimentally measured densities, ρ, viscosities, η, refractive indices, n _D , and specific conductivities, κ, data of glycine (0.02–0.10 m) in 0.01 m aqueous sodium dodecyl sulphate, cetyltrimethylammonium bromide, and triton X-100 (TX-100) solutions at 298.15, 303.15, 308.15, and 313.15 K. The above calculated parameters were found to be sensitive towards the interactions prevailing in the studied amino acid–surfactant–water systems. Moreover, fluorescence study using pyrene as a photophysical probe has also been carried out, the results of which support the conclusions obtained from other techniques.     

Generation and interrogation of a pure nuclear spin state by parahydrogen-enhanced NMR spectroscopy: a defined initial state for quantum computation

We describe a number of studies used to establish that parahydrogen can be used to prepare a two-spin system in a pure state, which is suitable for implementing NMR quantum computation. States are generated by pulsed and continuous-wave (CW) UV laser initiation of a chemical reaction between Ru(CO)(3)(L(2)) [where L(2) = dppe = 1,2-bis(diphenylphosphino)ethane or L(2) = dpae = 1,2-bis(diphenylarsino)ethane] with pure parahydrogen (generated at 18 K). This process forms Ru(CO)(2)(dppe)(H)(2) and Ru(CO)(2)(dpae)(H)(2) on a sub-microsecond time-scale. With the pulsed laser, the spin state of the hydride nuclei in Ru(CO)(2)(dppe)(H)(2) has a purity of 89.8 +/- 2.6% (from 12 measurements). To achieve comparable results by cooling would require a temperature of 6.6 mK, which is unmanageable in the liquid state, or an impractical magnetic field of 0.44 MT at room temperature. In the case of CW initiation, reduced state purities are observed due to natural signal relaxation even when a spin-lock is used to prevent dephasing. When Ru(CO)(3)(dpae) and pulsed laser excitation are utilized, the corresponding dihydride product spin state purity was determined as 106 +/- 4% of the theoretical maximum. In other words, the state prepared using Ru(CO)(3)(dpae) as the precursor is indistinguishable from a pure state.     

Development of agribiotechnology and biosafety regulations used to assess safety of genetically modified crops in Bangladesh

Bangladesh is on the verge of adopting genetically modified (GM) crops for commercial cultivation and consumption as feed and food. Most of the laboratories are engaged in tissue culture and molecular characterization on plants, whereas some have started living modified organism research with shortages of trained manpower, infrastructure, and funding. Nutritionally improved Golden Rice, biotech brinjal, and late blight-resistant potato are in contained trials in a greenhouse, and potato ring spot virus-resistant papaya is in the process of approval for a field trial. The government has taken some initiative in support of GM organism research, which include the formation of a Biotechnology Department in all institutes and the formation of the apex body, the National Task Force Committee on Biotechnology of Bangladesh under the chairpersonship of the Prime Minister. Biosafety policy guidelines and related aspects of biotechnology issues have been approved, and the laws are in the process of being promulgated. Being a party to the Cartagena Protocol, proper biosafety measures are regulated by the appropriate authority as stated. Although there are no laws made yet directly for biosafety of GM crops/foods, the relevant laws on agriculture, medicine, food, import, trade, environment, etc. may suffice and explain the situation.     

Homotopy simulation of nanofluid dynamics from a non-linearly stretching isothermal permeable sheet with transpiration

In this article we derive semi-analytical/numerical solutions for transport phenomena (momentum, heat and mass transfer) in a nanofluid regime adjacent to a nonlinearly porous stretching sheet by means of the Homotopy analysis method (HAM). The governing equations are reduced to a nonlinear, coupled, non-similar, ordinary differential equation system via appropriate similarity transformations. This system is solved under physically realistic boundary conditions to compute stream function, velocity, temperature and concentration function distributions. The results of the present study are compared with numerical quadrature solutions employing a shooting technique with excellent correlation. Furthermore the current HAM solutions demonstrate very good correlation with the non-transpiring finite element solutions of Rana and Bhargava (Commun. Nonlinear Sci. Numer. Simul. 17:212–226, 2012). The influence of stretching parameter, transpiration (wall suction/injection) Prandtl number, Brownian motion parameter, thermophoresis parameter and Lewis number on velocity, temperature and concentration functions is illustrated graphically. Transpiration is shown to exert a substantial influence on flow characteristics. Applications of the study include industrial nanotechnological fabrication processes.     

Dual solutions of time-dependent magnetohydrodynamic stagnation point boundary layer micropolar nanofluid flow over shrinking/stretching surface

Time-dependent, two-dimensional(2 D) magnetohydrodynamic(MHD)micropolar nanomaterial flow over a shrinking/stretching surface near the stagnant point is considered. Mass and heat transfer characteristics are incorporated in the problem. A model of the partial differential expressions is altered into the forms of the ordinary differential equations via similarity transformations. The obtained equations are numerically solved by a shooting scheme in the MAPLE software. Dual solutions are observed at different values of the specified physical parameters. The stability of first and second solutions is examined through the stability analysis process. This analysis interprets that the first solution is stabilized and physically feasible while the second one is un-stable and not feasible. Furthermore, the natures of various physical factors on the drag force, skin-friction factor, and rate of mass and heat transfer are determined and interpreted. The micropolar nanofluid velocity declines with a rise in the suction and magnetic parameters, whereas it increases by increasing the unsteadiness parameter.The temperature of the micropolar nanofluid rises with increase in the Brownian motion,radiation, thermophoresis, unsteady and magnetic parameters, but it decreases against an increment in the thermal slip constraint and Prandtl number. The concentration of nanoparticles reduces against the augmented Schmidt number and Brownian movement values but rises for incremented thermophoresis parameter values.     

The variation of heat transfer in a two‐sided lid‐driven differentially heated square cavity with nanofluids containing carbon nanotubes for physical properties of fluid dependent on temperature

The behavior of nanofluids containing cylindrical nanoparticles are investigated numerically inside a two‐sided lid‐driven differentially heated square cavity to gain insight into the convective recirculation and flow processes induced by a nanofluid. The physical properties of the base fluid such as viscosity, thermal conductivity and thermal expansion coefficient are, respectively, assumed to be temperature independent (taking the mean temperature of the left and right walls) and temperature dependent. A model is developed to analyze the behavior of nanofluids taking into account the nanoparticle volume fraction whereas the transport equations are solved numerically with finite volume approach using SIMPLEC algorithm. The left and right moving walls are maintained at different constant temperatures while the upper and bottom walls are thermally insulated. The directions of the moving walls were considered in a way that the force and natural convections aid each other. The governing parameter Richardson number was 0.1<Ri<50.0 but due to space constraints only the results for 0.1<Ri<10.0 from fluid flow are presented. It was found that the temperature dependency of physical properties at different Richardson numbers and nanoparticle volume fractions affects the fluid flow and heat transfer in the cavities. Finally, comparisons between the behaviors of the average Nusselt number at the left wall for two cases are presented. Copyright © 2011 John Wiley & Sons, Ltd.     

Di­chloro­bis­(tri­methyl­ene­thio­urea‐κS)antimony(III) chloride

In the title compound, [SbCl₂(C₄H₈N₂S)₂]Cl, the coordination around the Sb atom can be described as distorted pseudo‐octahedral. Both rings of the tri­methyl­ene­thio­urea ligands [alternatively 3,4,5,6‐tetrahydropyrimidine‐2(1H)‐thione] adopt an envel­ope conformation. The mol­ecules are connected into dimers in the ab plane by two intermolecular hydrogen bonds. The dimers are arranged into infinite one‐dimensional chains along the a axis as a result of the Cl^? ions forming intermolecular hydrogen bonds with three NH groups.     

Preparation of iron oxide nanocrystals by surfactant-free or oleic acid-assisted thermal decomposition of a Fe(III) alkoxide

A new non-hydrolytic, alkoxide-based route was developed to synthesize iron oxide nanocrystals. Surfactant-free thermal decomposition of the iron 2-methoxy-ethoxide precursors results in the formation of uniform iron oxide nanocrystals with an average size of 5.6 nm. Transmission electron microscope study shows that the nanocrystals are protected against aggregation by a repulsive surface layer, probably originating from the alkoxy-alkoxide ligands. Addition of oleic acid resulted in monodisperse nanocrystals with an average size of 4 nm. Mössbauer analysis confirmed that the nanocrystals mainly consisted of maghemite. Analysis of the magnetic hysteresis loop measurements and the zero field and field cooled measurements displayed an excellent fit to established theories for single-domain superparamagnetic nanocrystals and the size of the magnetic domains correlated well to the crystallite size obtained from transmission electron microscope.