Identification of prototypes from Ligustri Lucidi Fructus in rat plasma based on a data-dependent acquisition and multicomponent pharmacokinetic study

The identification and quantization of traditional Chinese medicine (TCM) are a challenge for researchers and industry. Using untargeted analytical methods, the in vivo detection and identification of TCM compounds are difficult because of the significant interference of endogenous substances. Fortunately, the ongoing development of new analytical technologies, especially Q-Orbitrap–MS, offers some solutions. Our team developed a holistic MS method, combining untargeted data-dependent MS² (dd-MS²) modes to extensively identify TCM prototypes in vivo. The method was successfully applied to the analysis of Ligustri Lucidi Fructus (LLF). LLF is a widely used TCM with a remarkable nourishing effect on the liver and kidney. In the study, we aimed to identify the prototypes in rat plasma after oral administration of LLF extract. Following separation on an HSS T₃ column, LLF extract and rat plasma were performed in untargeted dd-MS² mode. Forty-seven compounds were characterized in rats plasma as prototypes of LLF extract. Furthermore, seven major prototypes were chosen as pharmacokinetic markers to investigate LLF's pharmacokinetic properties. The results provides comprehensive determination of compounds in LLF both in vitro and in vivo, which is important for quality control, pharmacology studies and clinical use of LLF.     

Mössbauer study of the effect of potassium on iron oxide catalysts

One kind of catalyst used for dehydrogenation of ethylbenzene to styrene was investigated by⁵⁷Fe Mössbauer spectroscopy. The results show that the area ratioS _B /S _A of two Mössbauer subspectra of Fe_3-vO₄ produced after catalytic reaction depends on the amounts of potassium added to the catalysts. A tentative conclusion is that the effect of potassium in iron oxide catalysts could be related to the reduction of Fe³⁺ to Fe²⁺.     

EXISTENCE OF WEAK SOLUTIONS TO A p-LAPLACIAN PROBLEM INVOLVING DIRICHLET BOUNDARY CONDITION

In this paper, by virtue of Leray-Lions theorem, we are mainly concerned with the existence of weak solutions to a Dirichlet boundary value problem with the p-Laplacian operator.     

Effect of spatial refractive-index nonuniformities existed in a large-scale rapid growth KDP crystal on third-harmonic conversion

Effect of spatial refractive-index nonuniformities existed in a large-scale rapid growth KDP crystal (a type I frequency doubler at the wavelength of 1053 nm) on third-harmonic conversion is studied. Spatial refractive-index nonuniformities due to imperfections in the crystal structure which prohibit the attainment of phase matching at all locations in the crystal are measured with the orthogonal polarization interferometry technique. And a third-harmonic conversion experiment is conducted on a large-scale facility to investigate the influence of refractive-index nonuniformities on conversion efficiency and third-harmonic beam nearfield. According to the experimental results, refractive-index nonuniformities in this large-scale rapid growth KDP doubler do not reduce the third-harmonic conversion efficiency, but affect the third-harmonic beam nearfield.     

Network analyses for transmission characteristics of several kinds of curve-shaped groove waveguides

In this paper, the several kinds of the novel curve-shaped groove guides including the whole elliptic-, whole cosine- and hyperbolic-groove guides as the new millimeter wave transmission lines are presented. The dispersion, cut-off and band characteristics of the dominant mode for the several kinds of the curve-shaped groove guides are analysed by using the equivalent network method with transverse resonance. The obtained results have important values in their theoretical studies and actual applications of the curve-shaped groove waveguides.     

含环氧基的丙烯酸酯共聚物改性环氧树脂

合成了一系列含环氧基团的丙烯酸酯聚合物（ＨＧＭＢ），并对其改性环氧树脂／４，４‘－二氨基二苯基甲烷的抗冲性能，动态力学行为进行了考察，结果表明：当必性体系中加入质量分数为１５％的ＨＧＭＢ（甲基丙烯酸缩水甘油酯、甲基丙烯酸羟乙基酯、甲基丙烯酸甲酯、丙烯酸丁酯的摩尔分数分别为４．３％、５％、２５．７％、６５％）时，与空白体系相比，改性体系的冲击强度提高５０％，且玻璃化有所提高，模量没有降低。     

聚甲基丙烯酸羟乙酯树脂对胆红素的吸附研究

本文通过水相悬浮聚合制备了大孔交联聚甲基丙烯酸羟乙酯（PHEMA）树脂，研究了PHEMA树脂以及用乙醇胺功能基化后的PHEMA树脂对胆红素的吸附性能。结果表明，PHEMA树脂对胆红素的吸附性能受树脂孔结构，吸附温度，离子强度以及溶液中白蛋白的影响。该类吸附剂对胆红素有良好的吸附性能，其中用乙醇胺功能基化的树脂表现出更好的吸附能力。     

Cu_xZn_（1-x）O纳米复合物的制备及其抗菌性能

用柠檬酸溶胶-凝胶法制备了Cu2＋掺杂纳米ZnO复合粉末（CuxZn1-xO,x=0.02,0.05,0.08,0.10）,用X射线衍射、扫描电子显微镜、透射电子显微镜等表征了样品的物相、结构和形貌.结果表明纳米CuxZn1-xO粒子为六角纤锌矿结构,平均晶粒尺寸为25~35 nm.该纳米复合粉末对大肠杆菌、金黄色葡萄球菌和白色念珠菌具有强效抗菌性能,且随Cu2＋掺杂浓度的增加抗菌性能增强.其中,Cu0.1Zn0.9O对大肠杆菌、金黄色葡萄球菌和白色念珠菌的最小抑菌浓度分别为50,50,25 mg/L.该纳米复合粉末的抗菌性能明显优于普通无机抗菌剂.     

Analysis for dispersion characteristics of trapezoidal-groove waveguide

In this paper, the dispersion characteristics of the main mode for the trapezoidal-groove guides are analysed by using the approach of equivalent network with transverse resonance. The relationship curves between guide wavelength, phase constant and guide dimensions, frequency are obtained. The characteristics have important values in design, manufacture and application of groove guides.