A FLASH of insight into cellular chemistry: genetically encoded labels for protein visualization in vivo

Genetically encoded fluorescent labels, such as green fluorescent protein, make it possible to visualize a protein's natural distribution and environment in living cells. A new approach to protein labeling in living cells has been devised in which a small, membrane-permeable ligand binds with high affinity and specificity to a short peptide motif that can be incorporated into the protein of interest; the ligand becomes brightly fluorescent after binding to the peptide.     

Diffractive dissociation reaction np → Λ0K0p for incident neutron momenta between 30 and 70 GeV/c BIS-2 collaboration

We present results of the exclusive diffractive reaction np ⁰K⁰p at 0·08 < |t|< 0·53 GeV²/c² and momenta between 30–70 GeV/c at the Serpukhov neutron beam. Thet-dependence is exp (Bt) withB= 11·4± 2·3 (GeV/c)^–2 and it exhibits the diffractive minimum at ¦t¦ 0·28 GeV²/c² for ⁰K⁰ massesM < 1·8 GeV/c².B decreases with increasingM. Correlation with the beam direction is observed in the rest frame of the ⁰K⁰ system: the cross section rises for the forward-going ⁰. The rise is more pronounced for higherM. The cross section of reaction np ⁰K⁰p for 0<|t|< 0·53 GeV²/c² is 10·3 ± 2·5 ± 2·8 b.     

Inclusive production of vector mesons in π+ p interactions at 250 GeV/c

We report on a study of ρ⁰, ρ⁺, ω, \(\bar K^{*0} (892)\) andK ^*0 (892) inclusive production in π⁺ p interactions at 250 GeV/c, for ρ⁺, \(\bar K^{*0} (892)\) for the first time in a π⁺ p experiment. The data are compared withK ⁺ p data in the same experiment, with results of other experiments and with quark-parton models. Interesting differences are found between ρ^+,0 and ω production.     

Functional analysis and boundary-value problems: An introductory treatment

Book Review

Functional analysis and boundary-value problems: An introductory treatmentB. Dayanand Reddy: Pitman Monographs and Survey in Pure and Applied Mathematics, Longman Scientific and Technical, 1986, 333 pp., £45.00 net     

Kaon production in\bar pp interactions at c.m. energies from 200 to 900 GeV

A detailed analysis ofK _s ⁰ production in \(\bar pp\) |<2.5 the average transverse momentum is found to be 0.53±0.07 GeV/c at 200 GeV and 0.62±0.08 GeV/c at 900 GeV, which is an increase with respect to data at c.m. energies below 60 GeV. TheK _s ⁰ production cross sections in inelastic collisions are 29±4 mb at 200 GeV and 63±6 mb at 900 GeV, showing an increase compared to lower energy data. The central kaon density is found to increase as a logarithmic function of energy. At 900 GeV, where statistics are sufficient to allow one to draw conclusions, the average transverse momentum is higher in events with large charged multiplicity than in events with low multiplicity.     

Phase space dependence of the multiplicity distribution in π+ andpp collisions at 250 GeV/c

The charged particle multiplicity distribution has been studied for non-single-diffractive π⁺ p andpp collisions at \(\sqrt s = 22\) GeV, for full phase space as well as for intervals in rapidity, azimuthal angle and transverse momentum. In general, the multiplicity distribution is well described by a negative binomial. From comparison of the distribution for negative or positive particles to that of all charged particles, cascading is favoured as an interpretation over stimulated emission. Interesting consequences follow from a comparison of our results to those at collider energies and toe ⁺ e ^? data at comparable energy. Furthermore, evidence is given that the multiplicity distribution is not exactly of negative binomial type in every (connected or disconnected) phase space region.     

Forward-backward multiplicity correlations in σ+ p,K + p andpp collisions at 250 GeV/c

Forward-backward multiplicity correlations in σ⁺,K ⁺ p andpp collisions at 250 GeV/c ( \(\sqrt s \) =22 GeV) are given for all charges and for the different charge combinations. The correlations are found to be caused predominantly by centrally produced particles. It is demonstrated that this result is an agreement with observations at the ISR and the CERNp \(\bar p\) -Collider. The results are compared to expectations from LUND, DPM and FRITIOF Monte Carlo models and a geometrical picture relating correlations in hadron-hadron collisions toe ⁺ e ^? data in terms of impact parameters is tested.     

New books

Few-Body Systems — News Section

New books     

A validated spectrofluorometric method for the determination of celecoxib in capsules

A rapid, selective, sensitive and simple fluorescence method was developed for the direct determination of celecoxib in capsules. The capsules were emptied, pulverized and dissolved in either ethanol or acetonitrile, sonicated and filtered. Direct fluorescence emission was measured at 355±5 nm (exciting at 272 nm). The method was fully validated and the recoveries were excellent, even in presence of excipients.