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DSPMP: Discriminating secretory proteins of malaria parasite by hybridizing different descriptors of Chou's pseudo amino acid patterns 下载免费PDF全文
Guo‐Liang Fan Xiao‐Yan Zhang Yan‐Ling Liu Yi Nang Hui Wang 《Journal of computational chemistry》2015,36(31):2317-2327
Identification of the proteins secreted by the malaria parasite is important for developing effective drugs and vaccines against infection. Therefore, we developed an improved predictor called “DSPMP” (Discriminating Secretory Proteins of Malaria Parasite) to identify the secretory proteins of the malaria parasite by integrating several vector features using support vector machine‐based methods. DSPMP achieved an overall predictive accuracy of 98.61%, which is superior to that of the existing predictors in this field. We show that our method is capable of identifying the secretory proteins of the malaria parasite and found that the amino acid composition for buried and exposed sequences, denoted by AAC(b/e), was the most important feature for constructing the predictor. This article not only introduces a novel method for detecting the important features of sample proteins related to the malaria parasite but also provides a useful tool for tackling general protein‐related problems. The DSPMP webserver is freely available at http://202.207.14.87:8032/fuwu/DSPMP/index.asp . © 2015 Wiley Periodicals, Inc. 相似文献
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Wenzhong Huang Lingli Nang Xiangguang Li Lin Yuan Yinhai Ma Deqiang Liang 《中国化学》2015,33(10):1167-1172
Under the catalysis of only 3 mol% of Br2 at room temperature, indoles reacted rapidly with isatins to form biologically important 3,3‐bis(indole‐3‐yl)indoline‐2‐(1H)‐ones with high efficiency and wide substrate scope. Moreover, we demonstrated that p‐toluenesulfonic acid (TsOH) could serve as a surrogate to catalyze this transformation. 相似文献
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The composition dependence of the refractive index and its photo-induced variation have been calculated for the Ge1?xSex and As1?xSex binary glass systems, using the random network model. It is found that the refractive index has a minimum in Ge1?xSex at x = 0.8, while it shows a monotomic increase with increasing As content in As1?xSex glasses. The refractive index of the Ge1?xSex system decreases with illumination and the variation Δn of GeSe2 is ?0.0316, while the refractive index of the As1?xSex system increases with illumination and the variation of As2Se3 is 0.01. These results are in agreement with the experimental results reported by several workers. 相似文献
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An aqueous acidic polysaccharide, named rhamnogalacturonan (designated as TIP-D2) was isolated from Tribulus terrestris L by means of DEAE-cellulose chromatography and gel filtration. The molecular mass of TTP-D2 was estimated to be 26 KDa by gel filtration.TTP-D2 is composed of galacturonic acid, rhamnose, arabinose, galactose,fucose,mannose,xylose and glucose in a ratio of 71.4:13.5:5.6:4.9:3.1:1.9:1.9:1.0. The main chain structure of TTP-D2 was elucidated as an acidic hetero-polysaccaride with the connection of α-(1-4) galacturonic acid with α-(1-3) rhamnose by GC analysis of partially hydrolyzed products and determination of ^1H,^13C-NMR spectra. 相似文献
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We show that the Milnor monodromy and the Milnor numbers naturally appear in the characteristic cycles of irreducible perverse sheaves having the singularities of a complex hypersurface. We find also a new numerical constraint on the Milnor monodromy for general hypersurface singularities.Mathematics Subject Classification (1991): 14B05, 32C38, 32S40, 35A27Dedicated to the 60th anniversary of Prof P. Schapira who taught us the theory of D-modules 相似文献
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Hung LC Basri M Tejo BA Ismail R Nang HL Abu Hassan H May CY 《Colloids and surfaces. B, Biointerfaces》2011,87(1):180-186
Heat-sensitive bioactive compounds such as β-carotene and tocols, are widely used in the pharmaceutical and cosmetic fields. Their chemical stability in delivery systems is one of the major concerns in the production of nanostructured lipid carriers (NLCs). A previously established high-temperature high-pressure homogenisation technique involved in the preparation of NLCs can cause degradation of heat-sensitive compounds. Therefore, a novel preparation process needs to be developed to minimise the degradation of heat-sensitive active compounds during the preparation of NLCs. In this work, modified methods A and B were designed to minimise the degradation of β-carotene and tocols during the production of NLCs. These methods improved the chemical stability of heat-sensitive bioactive compounds (β-carotene and tocols) significantly compared to the previously established method. The physical stability of the formulation was maintained throughout study duration. 相似文献
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Hong Ha Thi Vu Timur Sh. Atabaev Nang Dinh Nguyen Yoon-Hwae Hwang Hyung-Kook Kim 《Journal of Sol-Gel Science and Technology》2014,71(3):391-395
Bifunctional magneto-optical nanocomposites with Fe3O4 nanoparticles as a core and erbium and lithium codoped gadolinium (Gd2O3:Er3+, Li+) as the shell were synthesized successfully using a simple urea homogeneous precipitation method. The fabricated Fe3O4@Gd2O3:Er3+, Li+ particles were characterized by X-ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, photoluminescence spectroscopy and quantum design vibrating sample magnetometry. The upconversion emission intensity was enhanced significantly comparing to that without Li+ ions. These bifunctional composites are expected to be potentially applied for drug delivery, cell separation and bioimaging. 相似文献
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