An expedient route to tetracyclo[6.5.2.02,7.09,13]pentadec-2(7),11-dien-14-one and tetracyclic framework of conidiogenol have been reported. Cycloaddition of annulated cyclohexa-2,4-dienone with cyclopentadiene, photochemical oxa-di-π-methane reaction and a highly unusual dehalogenation of bridgehead halogen are the key features of our methodology. 相似文献
A cylindrically symmetric inhomogeneous cosmological model with electromagnetic field for perfect fluid distributions is obtained. To get a determinate solution, a supplementary conditionA=(BC)n between metric potentials is used whereA, B, andC are functions of bothx andt andn is a constant. Some physical and geometrical properties of the model and behavior of electromagnetic field tensors are also discussed. 相似文献
The herbal medicament derived from the lipid soluble fraction obtained from Curcuma longa L. (Zingiberaceae) has shown potential neuroprotective activity in disorders like stroke. HM has been standardized with three biomarkers: ar-turmerone, α/β-turmerone and curlone, major bisabolane sesquiterpenes of turmeric oil. Development of a biaonalytical method for these sesquiterpenes was initiated to characterize its preclinical pharmacokinetics in rabbits to accelerate its development as a potential candidate for vascular complications. Since, the compounds are structurally and chemically very similar, gradient elution was utilized on a C-18 reversed phase column with a mobile phase comprising of acetonitrile and deionised water. The UV detector was set at wavelengths 240 and 270 nm. The sample clean-up was performed by protein precipitation with acetonitrile. The method was reasonably sensitive with limits of quantitation (LOQ) of 0.098 μg mL?1 in plasma for all the analytes. Accuracy and precision were within the acceptable limits, as indicated by relative standard deviation (% RSD) varying from 1.3 to 13.6% and bias values ranging from ?5.5 to 10.3%, respectively. Moreover, the analytes were stable in plasma even after three freeze-thaw cycles. The method was applied to generate preliminary pharmacokinetics of turmeric oil in rabbits after intravenous administration. 相似文献
The authors describe an electrochemical method for the determination of the anti-cancer drug nilutamide. The method is based on the use of a composite prepared from β-cyclodextrin, gold nanoparticles and graphene oxide (β-CD-AuNP/GO). An alkaline solution of glucose was used as a reducing agent to reduce the gold ions, rather than citric acid and a harmful reducing agent such as hydrazine and sodium borohydride. The structure and surface morphology of the β-CD-AuNP/GO composite was characterized by Raman spectroscopy, transmission electron microscopy and energy-dispersive X-ray spectroscopy. A screen printed carbon electrode was modified with the nanocomposite, and the resulting electrode used as a disposable sensor for the determination of nilutamide by differential pulse voltammetry. Best operated at a working voltage of 0.43 V (vs Ag/AgCl), it exhibits excellent electrocatalytic activity and a detection limit as low as 0.4 nM. The sensor was applied to the determination of nilutamide in (spiked) human serum, as well as in a tablet, where it displays good recovery and accuracy. The sensor is repeatable, reproducible, stable and selective even in the presence of other aromatic nitro compounds.
Graphical abstract An electrochemical method for the determination of the anti-cancer drug nilutamide is described. A screen printed carbon electrode is modified with the nanocomposite prepared from β-cyclodextrin, gold nanoparticles and graphene oxide (β-CD-AuNP/GO). Best operated at a working voltage of 0.43 V (vs Ag/AgCl), it exhibits excellent electrocatalytic activity and a detection limit as low as 0.4 nM. The sensor was applied to the determination of nilutamide in (spiked) human serum and a tablet where it displays good recovery and accuracy.
