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41.
Polymeric melaminium sulfate [(LH2)2(SO4)2]n has been synthesized by reaction of melamine L with sulfuric acid in aqueous solution. The compound was characterized by elemental analysis, 1H NMR, ESI MS and a single crystal X‐ray diffraction analysis. The architecture of the assembly formed is based on hydrogen bonded dimers of diprotonated melaminium cations (LH2)2+ which are linked by a hydrogen bonded network with sulfate ions forming 2D sheets. A 3D polymeric structure results from the presence of mutual hydrogen bonds between sulfate ions and melaminium cations in different sheets. Significant π‐π stacking is also present between the aromatic cations in this supramolecular arrangement. 相似文献
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Ghizlane Choukrani Jimena Álvarez Freile Natasha Ustyanovska Avtenyuk Wei Wan Kerstin Zimmermann Edwin Bremer Lars Dähne 《Particle & Particle Systems Characterization》2021,38(7):2100012
Nanoparticles may limit off-tumor/on-target ubiquitous activation of signaling by protein-based drugs. However, many challenges still exist in the design of a nanoparticle for protein delivery. In this study, conditions to establish vaterite nanoparticles as a pH-sensitive drug delivery system (DDS) for encapsulated protein drugs are comprehensively evaluated. Low coprecipitation pH of vaterite and protein prevents protein denaturation and yields high loading efficiency. Unprotected vaterite recrystallizes in aqueous solutions within 3 h to calcite and releases the loaded protein completely, but surface-modified particles with carboxyl groups containing polymers prove stable for more than 5 months. Notably, modification of vaterite with sulfonated polymers increases the loading of cationic proteins by a multiple. A system is developed for vaterite exposure to (pH) conditions under body-like-flow rates, with the dissolution of vaterite and simultaneous release of active proteins at tumor microenvironmental pH reaching up to 80% and only 20% at physiological pH within 2 h. Importantly, the immunomodulatory protein tumor necrosis factor preserves its native structure and fully retains functional activity in vitro after release from the particles. In conclusion, the studies described here provide a framework for the development of vaterite-based DDS as a carrier for bioactive protein-based therapeutics. 相似文献
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Holschumacher D Bannenberg T Ibrom K Daniliuc CG Jones PG Tamm M 《Dalton transactions (Cambridge, England : 2003)》2010,39(44):10590-10592
Frustrated carbene-borane Lewis pairs are able to affect the selective cleavage of one of the six P-P bonds in white phosphorus (P(4)) to afford an adduct, in which an abnormal carbene of the imidazolium-4-yl type and B(C(6)F(5))(3) are bound in a trans,trans fashion to a butterfly-like bicyclo[1.1.0]tetraphosphabutane moiety. 相似文献
46.
Harriet Okatch Barbara Ngwenya Keleabetswe M. Raletamo Kerstin Andrae-Marobela 《Analytica chimica acta》2012
The determination of four potentially toxic heavy metals, arsenic, chromium, lead and nickel in twelve plant species used for the treatment of perceived HIV and AIDS-associated opportunistic infections by traditional healers in Ngamiland District in Northern Botswana, a metal mining area, was carried out using atomic absorption spectrometry. The medicinal plants; Dichrostachys cinerea, Maerua angolensis, Mimusops zeyheri, Albizia anthelmintica, Plumbago zeylanica, Combretum imberbe, Indigofera flavicans, Clerodendrum ternatum, Solanum panduriforme, Capparis tomentosa, Terminalia sericea and Maytenus senegalensis contained heavy metals in varying quantities: arsenic 0.19–0.54 μg g−1, chromium 0.15–1.27 μg g−1, lead 0.12–0.23 μg g−1 and nickel 0.09–0.21 μg g−1 of dry weight. Chromium was found to be the most abundant followed by arsenic and lead. Nickel was undetectable in nine plant species. M. senegalensis contained the largest amounts of arsenic, chromium and lead. All metals determined were below the WHO permissive maximum levels. The possible maximum weekly intakes of the heavy metals following treatment regimes were insignificant compared to the provisional tolerable weekly intake levels recommended by WHO and the Joint FAO/WHO Expert Committee on Food Additives. This suggests that heavy metal exposure to patients originating from consumption of traditional medicinal plant preparations is within non health-compromising limits. 相似文献
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Oliver Neudert Dmitry Germanovich Zverev Christian Bauer Peter Blümler Hans Wolfgang Spiess Dariush Hinderberger Kerstin Münnemann 《Applied magnetic resonance》2012,43(1-2):149-165
Power-dependent Overhauser dynamic nuclear polarization (DNP) enhancements and continuous-wave electron paramagnetic resonance (EPR) spectra of nitroxide radicals were measured in the magnetic field of a mobile Halbach-array permanent magnet and compared with results from a commercially available electromagnet. DNP saturation factors for varying microwave power were obtained from both measurement series and used to investigate how the increased magnetic field inhomogeneity present in the Halbach magnet affects the saturation efficiency. An EPR detection system was designed to allow continuous-wave EPR measurements at microwave power up to 20?W. Our results show that despite the lower magnetic field homogeneity, a Halbach-array magnet can be used for EPR and DNP-enhanced nuclear magnetic resonance of high quality providing almost the same performance as a more homogeneous electromagnet. 相似文献
49.
Kerstin T. Wiss Patrick Theato 《Journal of polymer science. Part A, Polymer chemistry》2010,48(21):4758-4767
The synthesis of block copolymers via polymer conjugation of well‐defined building blocks offers excellent control over the structures obtained, but often several coupling strategies need to be explored to find an efficient one depending on the building blocks. To facilitate the synthesis of polymers with adjustable functional end‐groups for polymer conjugation, we report on the combination of activated ester chemistry with RAFT polymerization using a chain transfer agent (CTA) with a pentafluorophenyl ester (PFP‐CTA), which allows for flexible functionalization of either the CTA prior to polymerization or the obtained polymer after polymerization. Different polymethacrylates, namely PMMA, P(t‐BuMA) and PDEGMEMA, were synthesized with an alkyne‐CTA obtained from the aminolysis of the PFP‐CTA with propargylamine, and the successful incorporation of the alkyne moiety could be shown via 1H and 13C NMR spectroscopy and MALDI TOF MS. Further, the reactive α‐end‐groups of polymers synthesized using the unmodified PFP‐CTA could be converted into azide and alkyne end‐groups after polymerization, and the high functionalization efficiencies could be demonstrated via successful coupling of the resulting polymers via CuAAC. Thus, the PFP‐CTA allows for high combinatory flexibility in polymer synthesis facilitating polymer conjugation as useful method for the synthesis of block copolymers. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010 相似文献
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