Synthesis,characterization and electrochemical properties of novel metal free and zinc(II) phthalocyanines of ball and clamshell types

The phthalodinitrile derivative 1 was prepared by the reaction of 4-nitrophthalonitrile and 1,3-dimethoxy-4-tert-butylcalix[4]arene in dry dimethylsulfoxide as the solvent, in the presence of the base K₂CO₃, by nucleophilic substitution of an activated nitro group in an aromatic ring. The tetramerization of compound 1 gave a binuclear zinc(II) phthalocyanine and a metal-free phthalocyanine of the ball type, 2 and 3, respectively. Its condensation with 4,5-bis(hexylthio)phthalonitrile results in a binuclear phthalocyanine of the clamshell type, 4. The newly synthesized compounds were characterized by elemental analysis, UV–Vis, IR, MS and ¹H NMR spectra. The electronic spectra exhibit an intense π → π^∗ transition with characteristic Q and B bands of the phthalocyanine core. The electrochemical properties of 2–4 were examined by cyclic voltammetry in non-aqueous media. The voltammetric results showed that while there is no considerable interaction between the two phthalocyanine rings in 4, the splitting of a molecular orbital occurs as a result of the strong interaction between the phthalocyanine rings in 2 and 3.     

Better Optimization of Nonlinear Uncertain Systems (BONUS) for Vehicle Structural Design

With the continuous improvement of computational performance, vehicle structural design has been addressed using computational methods, resulting in more efficient development of new vehicles. Most simulation-based optimization approaches generate deterministic optimal designs without considering variability effects in modeling, simulation, and/or manufacturing. One of the main reasons for this omission is due to the fact that the computing time of a single crash analysis for vehicle structural design still requires significant computing time using a state-of-the-art computer. This calls for the development and implementation of an efficient optimization under uncertainty method. In this paper, a new integrated stochastic optimization method, which combines the advantages of metamodeling techniques and Better Optimization of Nonlinear Uncertain Systems (BONUS), is developed for vehicle side impact design. Nonlinear metamodels are built by using a stepwise regression method to replace the expensive computational model and BONUS is employed to obtain optimal designs under uncertainty. A benchmark problem for vehicle safety design is used to demonstrate the method. The main goal of this case study is to maintain or enhance the vehicle side impact test performance while minimizing the vehicle weight under various uncertainties.     

Adversarial Machine Learning for NextG Covert Communications Using Multiple Antennas

This paper studies the privacy of wireless communications from an eavesdropper that employs a deep learning (DL) classifier to detect transmissions of interest. There exists one transmitter that transmits to its receiver in the presence of an eavesdropper. In the meantime, a cooperative jammer (CJ) with multiple antennas transmits carefully crafted adversarial perturbations over the air to fool the eavesdropper into classifying the received superposition of signals as noise. While generating the adversarial perturbation at the CJ, multiple antennas are utilized to improve the attack performance in terms of fooling the eavesdropper. Two main points are considered while exploiting the multiple antennas at the adversary, namely the power allocation among antennas and the utilization of channel diversity. To limit the impact on the bit error rate (BER) at the receiver, the CJ puts an upper bound on the strength of the perturbation signal. Performance results show that this adversarial perturbation causes the eavesdropper to misclassify the received signals as noise with a high probability while increasing the BER at the legitimate receiver only slightly. Furthermore, the adversarial perturbation is shown to become more effective when multiple antennas are utilized.     

Structural variations among the aporphine-benzylisoquinoline dimers

$\text{Thalictrum}$$\text{minus}$ L. var. $\text{microphyllum}$ Boiss. (Ranunculaceae) has yielded (+)-istanbulamine ($\text{5}$) which is the first aporphine-benzylisoquinoline formed from one (+)-reticuline-type unit linked to a (+)-N-methylcoclaurine moiety. Other new dimers also present are (+)-bursanine ($\text{6}$) and (+)-iznikine ($\text{7}$).     

Multiplex identification of bacteria in bacterial mixtures with surface‐enhanced Raman scattering

Surface‐enhanced Raman scattering (SERS) is a technique capable of identifying each component in a mixture because of its intrinsically narrow spectral bands. In a clinical setting, the identification of bacteria from its initial culture by collecting the colonies on the culture plate significantly decreases the analysis time and the cost. The identification of bacteria from their mixtures is attempted using SERS. A simple mixing procedure of bacterial samples and concentrated colloidal suspension is proven to be mostly satisfactory for the generation of the reproducible SERS spectra that can be used for bacterial identification. The mixture of three different but related bacterial species Shigella sonnei, Proteus vulgaris, and Erwinia amylovara and three Escherichia coli strains (BFK13, BHK7, DH5 α) are used as model systems to test the feasibility of the approach. The results indicate that it is possible to identify the composition of a bacterial mixture. This approach can easily be utilized for the bacteria originating from the same source with similar growth profiles. Copyright © 2009 John Wiley & Sons, Ltd.     

Λ-strongly summable sequence spaces in n-normed spaces defined by ideal convergence and an Orlicz function

In this paper we introduce some certain new sequence spaces via ideal convergence, λ-sequence and an Orlicz function in n-normed spaces and study different properties of these spaces and also establish some inclusion results among them.     

PEG–Anthracene Hydrogels as an On‐Demand Stiffening Matrix To Study Mechanobiology

There is a growing interest in materials that can dynamically change their properties in the presence of cells to study mechanobiology. Herein, we exploit the 365 nm light mediated [4+4] photodimerization of anthracene groups to develop cytocompatible PEG‐based hydrogels with tailorable initial moduli that can be further stiffened. A hydrogel formulation that can stiffen from 10 to 50 kPa, corresponding to the stiffness of a healthy and fibrotic heart, respectively, was prepared. This system was used to monitor the stiffness‐dependent localization of NFAT, a downstream target of intracellular calcium signaling using a reporter in live cardiac fibroblasts (CFbs). NFAT translocates to the nucleus of CFbs on stiffening hydrogels within 6 h, whereas it remains cytoplasmic when the CFbs are cultured on either 10 or 50 kPa static hydrogels. This finding demonstrates how dynamic changes in the mechanical properties of a material can reveal the kinetics of mechanoresponsive cell signaling pathways that may otherwise be missed in cells cultured on static substrates.     

A Practical Approach for the Detection of Protein Tau with a Portable Potentiostat

Along with many factors, the change in protein tau isoforms, which has an obvious role in the function of microtubules, is an important biomarker of Alzheimer's disease. The aim of this study is to determine the protein Tau-441 with a portable potentiostat using a practical approach. For this purpose, screen printed electrodes (SPCEs) were first hydroxylated and then functional self-assembled monolayers were formed on the surface with 3-aminopropyltriethoxysilane (APTES). Evidence of anti-Tau being immobilized on to the surface was followed by techniques such as cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and Fourier transform infrared spectroscopy (FTIR). The constructed immunosensor showed a linear response within the concentration range of 0.0064–0.8 ng/mL for the target analyte Tau-441 and the limit of detection was found to be 0.0053 ng/mL. In addition, analytical behaviors such as reproducible measurements and storage life of the developed immunosensor with a portable potentiostat were also investigated. It has been demonstrated that Tau-441 can be captured with the help of portable device with sensitivity in CSF environment.