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111.
Pishnyak OP Tang S Kelly JR Shiyanovskii SV Lavrentovich OD 《Physical review letters》2007,99(12):127802
We study electric-field-induced dynamics of colloids in a nematic cell, experimentally and by computer simulations. Solid particles in the nematic bulk create director distortions of dipolar type. Elastic repulsion from the walls keeps the particles in the middle of cell. The ac electric field reorients the dipoles and lifts them to top or bottom, depending on dipole orientation. Once near the walls, the colloids are carried along two antiparallel horizontal directions by nematic backflow. Computer simulations of the backflow agree with the experiment. 相似文献
112.
Baker JG van Meter JR McWilliams ST Centrella J Kelly BJ 《Physical review letters》2007,99(18):181101
General relativity predicts the gravitational wave signatures of coalescing binary black holes. Explicit waveform predictions for such systems, required for optimal analysis of observational data, have so far been achieved primarily using the post-Newtonian (PN) approximation. The quality of this treatment is unclear, however, for the important late-inspiral portion. We derive late-inspiral waveforms via a complementary approach, direct numerical simulation of Einstein's equations. We compare waveform phasing from simulations of the last approximately 14 cycles of gravitational radiation from equal-mass, nonspinning black holes with the corresponding 2.5PN, 3PN, and 3.5PN orbital phasing. We find phasing agreement consistent with internal error estimates for either approach, suggesting that PN waveforms for this system are effective until the last orbit prior to final merger. 相似文献
113.
The correlation properties of speckle fields are studied for general paraxial systems. The previous studies on lateral and longitudinal speckle size for the case of free-space propagation (Fresnel transform) are generalized to the case of the linear canonical transform. These results have implications for the control of speckle size, through appropriate design of optical systems, with particular relevance for speckle interferometry. 相似文献
114.
Hideyuki Tatsuno Kasper S. Kjr Kristjan Kunnus Tobias C. B. Harlang Cornelia Timm Meiyuan Guo Pavel Chbera Lisa A. Fredin Robert W. Hartsock Marco E. Reinhard Sergey Koroidov Lin Li Amy A. Cordones Olga Gordivska Om Prakash Yizhu Liu Mads G. Laursen Elisa Biasin Frederik B. Hansen Peter Vester Morten Christensen Kristoffer Haldrup Zoltn Nmeth Dorottya Srosin Szemes va Bajnczi Gyrgy Vank Tim B. Van Driel Roberto Alonso‐Mori James M. Glownia Silke Nelson Marcin Sikorski Henrik T. Lemke Dimosthenis Sokaras Sophie E. Canton Asmus O. Dohn Klaus B. Mller Martin M. Nielsen Kelly J. Gaffney Kenneth Wrnmark Villy Sundstrm Petter Persson Jens Uhlig 《Angewandte Chemie (International ed. in English)》2020,59(1):364-372
Iron N‐heterocyclic carbene (NHC) complexes have received a great deal of attention recently because of their growing potential as light sensitizers or photocatalysts. We present a sub‐ps X‐ray spectroscopy study of an FeIINHC complex that identifies and quantifies the states involved in the deactivation cascade after light absorption. Excited molecules relax back to the ground state along two pathways: After population of a hot 3MLCT state, from the initially excited 1MLCT state, 30 % of the molecules undergo ultrafast (150 fs) relaxation to the 3MC state, in competition with vibrational relaxation and cooling to the relaxed 3MLCT state. The relaxed 3MLCT state then decays much more slowly (7.6 ps) to the 3MC state. The 3MC state is rapidly (2.2 ps) deactivated to the ground state. The 5MC state is not involved in the deactivation pathway. The ultrafast partial deactivation of the 3MLCT state constitutes a loss channel from the point of view of photochemical efficiency and highlights the necessity to screen transition‐metal complexes for similar ultrafast decays to optimize photochemical performance. 相似文献
115.
Ganesh Shenoy Jessica Ettedgui Chandrasekhar Mushti Jennifer Hong Kelly Lane Burchelle Blackman Hak-Sung Jung Yasuharu Takagi Yeonee Seol Martin Brechbiel Rolf E. Swenson Keir C. Neuman 《Molecules (Basel, Switzerland)》2022,27(3)
Carboxylic acid is a commonly utilized functional group for covalent surface conjugation of carbon nanoparticles that is typically generated by acid oxidation. However, acid oxidation generates additional oxygen containing groups, including epoxides, ketones, aldehydes, lactones, and alcohols. We present a method to specifically enrich the carboxylic acid content on fluorescent nanodiamond (FND) surfaces. Lithium aluminum hydride is used to reduce oxygen containing surface groups to alcohols. The alcohols are then converted to carboxylic acids through a rhodium (II) acetate catalyzed carbene insertion reaction with tert–butyl diazoacetate and subsequent ester cleavage with trifluoroacetic acid. This carboxylic acid enrichment process significantly enhanced nanodiamond homogeneity and improved the efficiency of functionalizing the FND surface. Biotin functionalized fluorescent nanodiamonds were demonstrated to be robust and stable single-molecule fluorescence and optical trapping probes. 相似文献
116.
Ellen de Nazar S. da Cruz Luana de Sousa Peixoto Jamile S. da Costa Rosa Helena V. Mouro Walnice Maria O. do Nascimento Jos Guilherme S. Maia William N. Setzer Joyce Kelly da Silva Pablo Luis B. Figueiredo 《Molecules (Basel, Switzerland)》2022,27(8)
Eugenia patrisii Vahl is a native and non-endemic myrtaceous species of the Brazilian Amazon. Due to few botanical and phytochemical reports of this species, the objective of the present work was to evaluate the seasonal variability of their leaf essential oils, performed by GC and GC-MS and chemometric analysis. The results indicated that the variation in oil yields (0.7 ± 0.1%) could be correlated with climatic conditions and rainy (R) and dry seasons (D). (E)-caryophyllene (R = 17.1% ± 16.0, D = 20.2% ± 17.7) and caryophyllene oxide (R = 30.1% ± 18.4, D = 14.1% ± 19.3) are the major constituents and did not display significant differences between the two seasons. However, statistically, a potential correlation between the main constituents of E. patrisii essential oil and the climatic parameters is possible. It was observed that the higher temperature and insolation rates and the lower humidity rate, which are characteristics of the dry season, lead to an increase in the (E)-caryophyllene contents, while lower temperature and insolation and higher humidity, which occur in the rainy season, lead to an increase in the caryophyllene oxide content. The knowledge of variations in the E. patrisii essential oil composition could help choose the best plant chemical profile for medicinal purposes. 相似文献
117.
Isabel V. L. Wilkinson Kelly J. Perkins Hannah Dugdale Lee Moir Aini Vuorinen Maria Chatzopoulou Sarah E. Squire Sebastian Monecke Alexander Lomow Marcus Geese Philip D. Charles Peter Burch Jonathan M. Tinsley Graham M. Wynne Stephen G. Davies Francis X. Wilson Fraydoon Rastinejad Shabaz Mohammed Kay E. Davies Angela J. Russell 《Angewandte Chemie (International ed. in English)》2020,59(6):2420-2428
Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disease arising from mutations in the dystrophin gene. Upregulation of utrophin to compensate for the missing dystrophin offers a potential therapy independent of patient genotype. The first‐in‐class utrophin modulator ezutromid/SMT C1100 was developed from a phenotypic screen through to a Phase 2 clinical trial. Promising efficacy and evidence of target engagement was observed in DMD patients after 24 weeks of treatment, however trial endpoints were not met after 48 weeks. The objective of this study was to understand the mechanism of action of ezutromid which could explain the lack of sustained efficacy and help development of new generations of utrophin modulators. Using chemical proteomics and phenotypic profiling we show that the aryl hydrocarbon receptor (AhR) is a target of ezutromid. Several lines of evidence demonstrate that ezutromid binds AhR with an apparent KD of 50 nm and behaves as an AhR antagonist. Furthermore, other reported AhR antagonists also upregulate utrophin, showing that this pathway, which is currently being explored in other clinical applications including oncology and rheumatoid arthritis, could also be exploited in future DMD therapies. 相似文献
118.
Prinessa Chellan Kelly Chibale Gregory S. Smith 《Journal of chemical crystallography》2011,41(5):747-750
Abstract
Reaction of a salicylaldehyde semicarbazone ligand with PdCl2(PPh3)2 yields an unexpected binuclear Pd(II) complex, 2. The complex crystallizes in a triclinic system with a P-1 space group, with unit cell parameters a = 14.0283(3) ?, b = 15.2603(3) ?, c = 18.7142(3) ?, α = 66.662(10)°, β = 86.162(10)°, γ = 76.265(10)°, Z = 2. The semicarbazone ligand acts as a tridentate chelating donor to one palladium metal centre, forming a five- and six- membered ring, and a monodentate donor to the second palladium centre. There are four molecules of solvent per complex molecule in the asymmetric unit. Each metal centre is contained within a slightly distorted square-planar environment. 相似文献119.
120.