全文获取类型
收费全文 | 468篇 |
免费 | 17篇 |
专业分类
化学 | 393篇 |
晶体学 | 3篇 |
力学 | 9篇 |
数学 | 18篇 |
物理学 | 62篇 |
出版年
2023年 | 8篇 |
2022年 | 3篇 |
2021年 | 8篇 |
2020年 | 11篇 |
2019年 | 10篇 |
2018年 | 9篇 |
2017年 | 10篇 |
2016年 | 13篇 |
2015年 | 13篇 |
2014年 | 21篇 |
2013年 | 23篇 |
2012年 | 41篇 |
2011年 | 40篇 |
2010年 | 20篇 |
2009年 | 14篇 |
2008年 | 40篇 |
2007年 | 32篇 |
2006年 | 33篇 |
2005年 | 23篇 |
2004年 | 20篇 |
2003年 | 9篇 |
2002年 | 19篇 |
2001年 | 6篇 |
2000年 | 5篇 |
1999年 | 2篇 |
1998年 | 3篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1992年 | 2篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 4篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1976年 | 2篇 |
1975年 | 6篇 |
1974年 | 1篇 |
1973年 | 6篇 |
1969年 | 2篇 |
1968年 | 3篇 |
1967年 | 1篇 |
1966年 | 1篇 |
1965年 | 2篇 |
排序方式: 共有485条查询结果,搜索用时 140 毫秒
481.
Dr. Kazuto Suzuki Dr. Joshua Kyle Stanfield Dr. Keita Omura Dr. Yuma Shisaka Dr. Shinya Ariyasu Chie Kasai Dr. Yuichiro Aiba Dr. Hiroshi Sugimoto Prof. Dr. Osami Shoji 《Angewandte Chemie (International ed. in English)》2023,62(13):e202215706
Catching the structure of cytochrome P450 enzymes in flagrante is crucial for the development of P450 biocatalysts, as most structures collected are found trapped in a precatalytic conformation. At the heart of P450 catalysis lies Cpd I, a short-lived, highly reactive intermediate, whose recalcitrant nature has thwarted most attempts at capturing catalytically relevant poses of P450s. We report the crystal structure of P450BM3 mimicking the state in the precise moment preceding epoxidation, which is in perfect agreement with the experimentally observed stereoselectivity. This structure was attained by incorporation of the stable Cpd I mimic oxomolybdenum mesoporphyrin IX into P450BM3 in the presence of styrene. The orientation of styrene to the Mo-oxo species in the crystal structures sheds light onto the dynamics involved in the rotation of styrene to present its vinyl group to Cpd I. This method serves as a powerful tool for predicting and modelling the stereoselectivity of P450 reactions. 相似文献
482.
Dewi Yana Tomoko Shimizu Keita Hamasaki Hisakazu Mihara Akihiko Ueno 《Macromolecular rapid communications》2002,23(1):11-15
A cyclodextrin‐peptide hybrid (17NNβ) bearing two naphthalene units in the peptide side chain has been designed and synthesized as a novel chemosensor molecule. Circular dichroism study of the compound revealed that the peptide has α‐helix structure with a helix content of 41%. The peptide revealed both monomer and excimer emission and the intensity of the excimer emission increased while that of the monomer emission decreased upon addition of the guest compound. This behavior was observed for various guest molecules, suggesting that the system can be used for detecting molecules in aqueous solution. 相似文献
483.
484.
Dr. Yoshiyuki Manabe Yuki Iizuka Ryuku Yamamoto Keita Ito Kanae Hatano Dr. Kazuya Kabayama Prof. Koichi Fukase 《Angewandte Chemie (International ed. in English)》2023,62(30):e202304779
Antibody dynamics on membranes, such as endocytosis and clustering, are vital in determining antibody functions. In this study, we demonstrated that glycan conjugation can modulate antibody dynamics through the glycan–lectin interaction to regulate its potency. The anti-HER2 antibody, an anti-breast-cancer antibody, was conjugated with galactose-containing N-glycan, and its internalization was suppressed by interaction with galectin-3, leading to enhanced complement-dependent cytotoxic (CDC) activity. This glycan–antibody conjugate is proposed as a new approach to modulate antibody activity and may provide an alternative strategy for redeveloping antibody drugs that do not exhibit sufficient activity. 相似文献
485.
Hawa Keita Prof. Simon J. Meek 《Angewandte Chemie (International ed. in English)》2023,62(34):e202306277
A practical method for the preparation of quaternary and tertiary allyl-substituted heteroarenes by site-selective couplings of heteroaryl nitriles and allylic nucleophiles is disclosed. Transformations utilize readily accessible stable reagents, proceed in the presence of a Lewis base activator, and undergo aryl-C(sp3) quaternary and tertiary carbon formation with high γ-selectivity (up to >98 : 2 γ : α). 相似文献