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41.
Toru Tachihara Susumu Ishizaki Yoshiko Kurobayashi Hiroshi Tamura Youichi Ikemoto Atsushi Onuma Keisuke Yoshikawa Tetsuya Yanai Takeshi Kitahara 《Helvetica chimica acta》2003,86(2):274-279
All possible stereoisomers of imine derivatives 1 – 4 , which have the characteristic roast odor of seafood, were synthesized. As a result of odor evaluation of all isomers, we found that each isomer has a different and characteristic odor of roasted seafood. 相似文献
42.
43.
Sugimoto K Nishida M Otsuka M Makino K Ohkubo K Mori Y Morii T 《Chemistry & biology》2004,11(4):475-485
Real-time observation of messenger molecules in individual intact cells is essential for physiological studies of signaling mechanisms. We have developed a novel inositol 1,4,5-trisphosphate (IP(3)) sensor based on the pleckstrin homology (PH) domain from phospholipase C (PLC) delta. The environmentally sensitive fluorophore 6-bromoacetyl-2-dimethyl-aminonaphtalene was conjugated to the genetically introduced cysteine at the mouth of the IP(3) binding pocket for enhanced IP(3) selectivity and for rapid and direct visualization of intracellular IP(3) > or = 0.5 microM as fluorescence emission decreased. The probe, tagged with arginine-rich sequences for efficient translocation into various cell types, revealed a major contribution of Ca2+ influx to PLC-mediated IP(3) production that boosts Ca2+ release from endoplasmic reticulum. Thus, our IP(3) probe was extremely effective to quantitatively assess real-time physiological IP(3) production via those pathways formed only in the intact cellular configuration. 相似文献
44.
Oxetanes were reacted with lithium enolates generated from esters or amides in the presence of boron trifluoride etherate to give δ-hydroxyesters or amides in high yield, which were hydrolyzed and converted to δ-lactones. 相似文献
45.
Abstract —An action spectrum for the inactivation of ribonuclease A photosensitized with 4-thiouridylic acid follows the shape of the absorption spectrum of an RNase-thiouridylate complex or of the unbound nucleotide. The quantum yield is 3.3 times 10-3 . Statistical analysis of the data suggests that only the bound nucleotide participates in the photoinactivation. An Arrhenius plot for the first-order rate constants of inactivation gives a straight line in the range 0–40C and an apparent activation energy of photoinactivation of 5.7 kcal/mol. The 4-thiouridylate-sensitized photoinactivation of ribonuclease A is regarded as a kind of photodynamic action in which the substrate analogue plays the role of photosensitizer. 相似文献
46.
Majima K Takita R Okada A Ohshima T Shibasaki M 《Journal of the American Chemical Society》2003,125(51):15837-15845
We describe the development of a general catalytic asymmetric Michael reaction of acyclic beta-keto esters to cyclic enones, in which asymmetric induction occurs at the beta-position of the acceptors. Among the various asymmetric catalyst systems examined, the newly developed La-NR-linked-BINOL complexes (R = H or Me) afforded the best results in terms of reactivity and selectivity. In general, the NMe ligand 2 was suitable for the combination of small enones and small beta-keto esters, and the NH ligand 1 was suitable for bulkier substrates (steric tuning of the catalyst). Using the La-NMe-linked-BINOL complex, the Michael reaction of methyl acetoacetate (8a) to 2-cyclohexen-1-one (7b) gave the corresponding Michael adduct 9ba in 82% yield and 92% ee. The linker heteroatom in linked-BINOL is crucial for achieving high reactivity and selectivity in the Michael reaction of beta-keto esters. The amine moiety in the NR-linked-BINOL can also tune the Lewis acidity of the central metal (electronic tuning of the catalyst), which was supported by density functional studies and experimental results. Another advantage of the NR-linked-BINOL ligand as compared with O-linked-BINOL is the ease of modifying a substituent on the amine moiety, making it possible to synthesize a variety of NR-linked-BINOL ligands for further improvement or development of new asymmetric catalyses by introducing additional functionality on the linker with the amine moiety. The efficiency of the present asymmetric catalysis was demonstrated by the synthesis of the key intermediate of (-)-tubifolidine and (-)-19,20-dihydroakuammicine in only five steps compared to the nine steps required by the original process from the Michael product of malonate. This strategy is much more atom economical. On the basis of the results of mechanistic studies, we propose that a beta-keto ester serves as a ligand as well as a substrate and at least one beta-keto ester should be included in the active catalyst complex. Further improvement of the reaction by maintaining an appropriate ratio of the La-NMe-linked-BINOL complex and beta-keto esters is also described. 相似文献
47.
The determination of dithiocarbamates by catalytic thermometric titration is described. The dithiocarbamates can be determined in the range 0.5-20 mumole with relative errors of about 5%. 相似文献
48.
Fluoroalkanoyl peroxides were reacted with adamantane in the presence of radical polymerizable monomers such as acrylic acid, acryloylmorpholine, and N,N‐dimethylacrylamide to afford fluoroalkyl end‐capped oligomers having adamantane units in the main chains via a radical process under very mild conditions. Thermal stability of these new fluorinated adamantane co‐oligomers thus obtained became higher than that of the corresponding fluorinated homo‐oligomers having no adamantane units. Interestingly, these fluorinated adamantane co‐oligomers exhibited good solubility in traditional organic solvents such as methanol, ethanol, tetrahydrofuran, chloroform, benzene, dimethylsulfoxide and N,N‐dimethylformamide including water, although the parent adamantane exhibited no solubility in water, methanol and dimethylsulfoxide. Furthermore, these adamantane co‐oligomers were able to reduce the surface tension effectively to form the nanometer size‐controlled self‐assembled fluorinated molecular aggregates. Copyright © 2005 John Wiley & Sons, Ltd. 相似文献
49.
Hiroshi Tanaka Toru Masuko Keisuke Homma Saburo Okajima 《Journal of polymer science. Part A, Polymer chemistry》1969,7(7):1997-2006
Polypropylene films of various isotacticities and crystallinities were stretched biaxially in one step in air at 140–152°C or polyaxially in poly(ethylene glycol) at 130–160°C, and the morphological changes were studied by electron microscopy (replica). In the initial stage of stretching, with vA = 1.4, the spherulites of one of the films used for the experiment were broken both from the centers and boundaries, and those of another film were broken mainly from the center. This difference in the deformation behavior seems to be characteristic of the film properties and independent of the method of stretching, although the factors involved are still unknown. On further stretching (vA = 22), well annealed spherulites were broken into many small blocklike fragments with unfolded fibrils running among them, particularly at the low stretching temperature (140°C), and fibrillation proceeded at the expense of the residual fragments. In the case of quenched or slightly crystallized material, the fragments were dendritic and divided into finer and finer fibrils on stretching. At elevated temperature, however, even for well annealed spherulites, the deformation behavior resembles that of the quenched material, and at a high degree of stretching the spherulites take on the fibrillar net structure in every case. In films containing a high amount of atactic fraction, radial, tangential, and boundary cracking occurred more easily, and broad fibrils were observed across the cracks. 相似文献
50.
Masami Sawada Yasuo Okumura Hitoshi Yamada Yoshio Takai Shigetoshi Takahashi Takahiro Kaneda Keiji Hirose Soichi Misumi 《Journal of mass spectrometry : JMS》1993,28(12):1525-1528
Using fast atom bombardment (FAB) mass spectrometry (MS), cross-chiral relationships were confirmed for the first time for the diasteromeric host-guest complexations between the chiral crown ether host (1) and the chiral organic ammonium ion guest (2) on the basis of the relative peak intensities (RPI). Both host–guest combinations (R, R, R, R) – 1, (R) – 2 and (S, S, S, S) – 1, (S) – 2 obviously provided larger RPI values than the combination of both (R, R, R, R) – 1, (S) – 2 and (S, S, S, S) – 1, (R) – 2 by a factor of 1.6 as an averaged value: 1.87 (n = 4)/1.16 (n = 4) = 1.6. These results are consistent with the expected stabilities of the host-guest complexations by CPK model examinations. Successfully observed cross-chiral examinations strongly suggest a potentially useful FABMS/RPI methodology for rapidly searching newly designed and synthesized crown ether-like host compounds with a higher degree of enantioselectivity. 相似文献