全文获取类型
收费全文 | 646篇 |
免费 | 14篇 |
专业分类
化学 | 479篇 |
晶体学 | 6篇 |
力学 | 11篇 |
数学 | 28篇 |
物理学 | 136篇 |
出版年
2021年 | 7篇 |
2020年 | 8篇 |
2019年 | 10篇 |
2018年 | 5篇 |
2017年 | 6篇 |
2016年 | 7篇 |
2015年 | 5篇 |
2014年 | 15篇 |
2013年 | 24篇 |
2012年 | 14篇 |
2011年 | 22篇 |
2010年 | 15篇 |
2009年 | 10篇 |
2008年 | 34篇 |
2007年 | 29篇 |
2006年 | 32篇 |
2005年 | 21篇 |
2004年 | 25篇 |
2003年 | 27篇 |
2002年 | 31篇 |
2001年 | 33篇 |
2000年 | 27篇 |
1999年 | 15篇 |
1998年 | 6篇 |
1997年 | 14篇 |
1996年 | 8篇 |
1995年 | 14篇 |
1994年 | 5篇 |
1993年 | 9篇 |
1992年 | 21篇 |
1991年 | 13篇 |
1990年 | 12篇 |
1989年 | 3篇 |
1988年 | 8篇 |
1987年 | 7篇 |
1986年 | 5篇 |
1985年 | 18篇 |
1984年 | 17篇 |
1983年 | 8篇 |
1982年 | 5篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1979年 | 5篇 |
1978年 | 5篇 |
1977年 | 7篇 |
1975年 | 6篇 |
1974年 | 3篇 |
1973年 | 10篇 |
1971年 | 3篇 |
1968年 | 4篇 |
排序方式: 共有660条查询结果,搜索用时 31 毫秒
91.
Ogawa T Hattori H Kaneko R Ito K Iwai M Mizutani Y Arinobu T Ishii A Seno H 《Analytical and bioanalytical chemistry》2011,400(7):1959-1965
In this report, a high-throughput and sensitive method for analysis of eight central-acting muscle relaxants in human plasma
by ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) in the positive and negative ionization modes
using tolbutamide as internal standard is presented. After pretreatment of a plasma sample by solid-phase extraction with
an Oasis HLB cartridge, muscle relaxants were analyzed by UPLC with Acquity UPLC BEH C18 column and Acquity TQD tandem quadrupole mass spectrometer equipped with an electrospray ionization interface. The calibration
curves for muscle relaxants spiked into human plasma equally showed good linearities in the nanogram per milliliter order
range. The detection limits (signal-to-noise ratio = 3) was as low as 0.1–2 ng/mL. The method gave satisfactory recovery rates,
accuracy, and precision for quality control samples spiked with muscle relaxants. To further validate the present method,
250 mg of chlorphenesin carbamate was orally administered to a healthy male volunteer, and the concentrations of chlorphenesin
carbamate in plasma were measured 0.5, 1, 2, 4, 6, and 8 h after dosing; their concentrations in human plasma were between
0.62 and 2.44 μg/mL. To our knowledge, this is the first report describing simultaneous analysis of over more than two central-acting
muscle relaxants by liquid chromatography–tandem mass spectrometry. This has been realized by the capability of our instrument
for simultaneous multiple reaction monitoring of the target compounds in both positive and negative ionization modes. Therefore,
the present method seems very useful in forensic and clinical toxicology and pharmacokinetic studies. 相似文献
92.
Nakamura Y Tanaka S Serizawa R Morohashi N Hattori T 《The Journal of organic chemistry》2011,76(7):2168-2179
Practical methods are described for the preparation of monoamines 4 and 1,3-diamines 5, bearing one or two amino group(s) instead of the hydroxy group(s) at the 28-position or at both the 26- and 28-positions of p-tert-butylcalix[4]arene (1a) and p-tert-butylthiacalix[4]arene (1b), via the Ullmann-type amination or amidation. Thus, the copper-catalyzed or mediated amination of the 1,3-bistriflate ester (2a) of 1a with benzylamine affords either mono(benzylamino) triflate 7a or 1,3-bis(benzylamine) 8 in a high yield, depending on the reaction conditions. On the other hand, the 1,3-bistriflate ester (2b) of 1b resists disubstitution and produces, under stoichiometric conditions, mono(benzylamino) triflate 7b. The disubstitution of 2b is achieved by amidation with tosylamide, giving 1,3-bis(tosylamide) 17b. The hydrogenolysis of the benzylamino moiety of 7a, followed by the hydrolysis of the Tf moiety, affords monoamine 4a, while the hydrogenolysis of 8 affords 1,3-diamine 5a. The amino moiety of 7b can be deprotected under acidic conditions to give, after hydrolysis, monoamine 4b. The hydrolysis of 17b affords 1,3-diamine 5b. The overall yields of compounds 4a, 4b, 5a, and 5b are 72%, 45%, 78%, and 24%, respectively, based on commercially available compounds 1 and are much higher than the ones previously reported in the literature. 相似文献
93.
As a part of our studies on the metabolism of crude drug components by intestinal bacteria, gentiopicroside (a secoiridoid glucoside isolated from Gentiana lutea), was anaerobically incubated with various defined strains of human intestinal bacteria. Many species had ability to transform it to a series of metabolites. Among them, Veillonella parvula ss parvula produced five metabolites, which were identified as erythrocentaurin, gentiopicral, 5-hydroxymethylisochroman-1-one,5-hydroxymethylisochromen-1- one and trans-5,6-dihydro-5-hydroxymethyl-6-methyl-1H,3H-pyrano[3,4-c]pyra n-1-one. 相似文献
94.
K. Ogura T. Hattori M. Hirata M. Asano M. Yoshida M. Tamada H. Omichi N. Nagaoka H. Kubota R. Katakai 《Radiation measurements》1995,25(1-4):159-162
Several types of copolymers of CR-39 were prepared to find its usefulness as a nuclear track detector of high sensitivity. Track responses of these copolymers were investigated by irradiating energetic ions from proton through Ar. The copolymer of CR-39 monomer with N-isopropylacrylamide (NIPAAm) shows higher sensitivity than that of pure CR-39 for low LET particles such as protons. Preliminary results are reported for the track responses of copolymers (CR-39/NIPAAm) with various contents of NIPAAm as well as the etching properties. 相似文献
95.
N. Usami J. Arai E. S. Kim K. Ota T. Hattori Y. Shiraki 《Physica E: Low-dimensional Systems and Nanostructures》1998,2(1-4)
Two approaches to control the position and the size of semiconductor islands are proposed. The first method is to perform overgrowth on a cleaved edge of strained multiple quantum wells which acts as a substrate with a periodically modulated lattice constant, thus inducing a periodic strain to the overgrown layer. The second method is to selectively grow islands in specific windows defined by electron beam lithography. Both the methods are applied to the Ge/Si system and the controllability of the Ge island formation is demonstrated. 相似文献
96.
The indices of refraction of pure ZnS, ZnSe and ZnTe at 2, 80, and 300°K have been measured in the spectral region from 10 to 100 cm-1. The indices of refraction can be described by the simple dispersion formula for an undamped harmonic oscillator. The static dielectric constants of these materials are obtained from the best fit parameters using a simple dispersion equation. The average indices of refraction of pure CdS and CdTe at 5°K in the spectral region from 10 to 100 cm-1 have also been measured. 相似文献
97.
98.
99.
100.
Masaru Matsuo Hiroshi Hattori Shunji Nomura Hiromichi Kawai 《Journal of Polymer Science.Polymer Physics》1976,14(2):223-238
A model relating crystal orientation to the deformation of nylon-6 spherulites under uniaxial stretching is discussed in terms of the orientation distribution functions of reciprocal lattice vectors of crystal planes, such as the (002) and (200) planes. The distribution functions calculated from the model are compared with those obtained from x-ray diffraction experiments. It is found that the crystal a axis and, consequently, the direction of hydrogen bonds within the crystal (α modification) orient parallel to the lamellar axis in the undeformed state, and that the crystal orientation behavior of nylon-6 is much different from that of low-density polyethylene, being characterized by much smaller values of the reorientation parameters of crystallites within orienting lamellae. Moreover, small-angle light scattering for Hv and Vv polarization is also calculated on the basis of the spherulite deformation model by taking the nylon-6 crystal as having orthogonal–biaxial symmetry in optical anisotropy. It is concluded that the Hv scattering can be realized in terms of the proposed model for spherulite deformation by taking into account a considerable contribution of hydrogen bonds to the molecular polarizability, so as to make the polarizability along the crystal a axis larger than that along the b axis. In other words, this conclusion suggests positively birefringent spherulites in the nylon-6 samples studied. 相似文献