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41.
42.
Wai Keen Chung Ying Hou Melissa Holstein Alexander Freed George I. Makhatadze Steven M. Cramer 《Journal of chromatography. A》2010,1217(2):191-198
A library of cold shock protein B mutant variants was employed to examine differences in protein binding behavior in ion exchange and multimodal chromatography. Single site mutations introduced at charged amino acids on the protein surface resulted in a homologous protein set with varying charge density and distribution. The retention times of the mutants varied significantly during linear gradient chromatography in both systems. The majority of the proteins were more strongly retained on the multimodal cation exchange resin as compared to the traditional cation exchanger. Further, the elution order of the mutants on the multimodal resin was different from that obtained with the ion exchanger. Quantitative structure–property relationship models generated using a support vector regression technique were shown to provide good predictions for the retention times of protein mutants on the multimodal resin. A coarse-grained ligand docking package was employed to examine the various interactions between the proteins and ligands in free solution. The multimodal ligand was shown to utilize multiple interaction types to achieve stronger retention on the protein surface. The use of this protein library in concert with the qualitative and quantitative analyses presented in this paper provides an improved understanding of protein behavior in multimodal chromatographic systems. 相似文献
43.
Dr. Thomas D. Bennett Dr. Paul J. Saines Prof. David A. Keen Dr. Jin‐Chong Tan Prof. Anthony K. Cheetham 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(22):7049-7055
The I2‐sorption and ‐retention properties of several existing zeolitic imidazolate frameworks (ZIF‐4, ‐8, ‐69) and a novel framework, ZIF‐mnIm ([Zn(mnIm)2]; mnIm=4‐methyl‐5‐nitroimidazolate), have been characterised using microanalysis, thermogravimetric analysis and X‐ray diffraction. The topologically identical ZIF‐8 ([Zn(mIm)2]; mIm=2‐methylimidazolate) and ZIF‐mnIm display similar sorption abilities, though strikingly different guest‐retention behaviour upon heating. We discover that this guest retention is greatly enhanced upon facile amorphisation by ball milling, particularly in the case of ZIF‐mnIm, for which I2 loss is retarded by as much as 200 °C. It is anticipated that this general approach should be applicable to the wide range of available metal–organic framework‐type materials for the permanent storage of harmful guest species. 相似文献
44.
Laura M. Lilley Sarah Kamper Michael Caldwell Zer Keen Chia David Ballweg Luke Vistain Jeffrey Krimmel Teresa Anne Mills Keith MacRenaris Paul Lee Emily Alexandria Waters Thomas J. Meade 《Angewandte Chemie (International ed. in English)》2020,59(1):388-394
Our lab has developed a new series of self‐immolative MR agents for the rapid detection of enzyme activity in mouse models expressing β‐galactosidase (β‐gal). We investigated two molecular architectures to create agents that detect β‐gal activity by modulating the coordination of water to GdIII. The first is an intermolecular approach, wherein we designed several structural isomers to maximize coordination of endogenous carbonate ions. The second involves an intramolecular mechanism for q modulation. We incorporated a pendant coordinating carboxylate ligand with a 2, 4, 6, or 8 carbon linker to saturate ligand coordination to the GdIII ion. This renders the agent ineffective. We show that one agent in particular (6‐C pendant carboxylate) is an extremely effective MR reporter for the detection of enzyme activity in a mouse model expressing β‐gal. 相似文献
45.
H.S. Tang T.R. Keen R. Khanbilvardi 《Communications in Nonlinear Science & Numerical Simulation》2009,14(7):2935-2947
This paper presents a framework for synchronously coupling wave, current, sediment transport, and seabed morphology for the accurate simulation of multi-physics coastal ocean processes. The governing equations, which represent models that are commonly adopted in practical simulations, are discretized using finite-difference methods. The resulting system is validated against analytical solutions. In order to test the performance of the proposed framework and the numerical methods, dam-break flow over a mobile-bed and evolution of a wave-driven sand dune are simulated. The interactions among waves, currents, and seabed morphology are illustrated. 相似文献
46.
Given a random sequence of holomorphic maps of the unit disk to a subdomain , we consider the compositions
The sequence is called the iterated function system coming from the sequence We prove that a sufficient condition on the domain for all limit functions of any to be constant is also necessary. We prove that the condition is a quasiconformal invariant. Finally, we address the question of uniqueness of limit functions.
The sequence is called the iterated function system coming from the sequence We prove that a sufficient condition on the domain for all limit functions of any to be constant is also necessary. We prove that the condition is a quasiconformal invariant. Finally, we address the question of uniqueness of limit functions.
47.
48.
The reaction of the aryne complex (PEt3)2Ni(eta2-C6H2-4,5-F2) with a catalytic amount of Ni(PEt3)2 results in a dinuclear Ni(I) complex from the coupling of the isomer (PEt3)2Ni(eta2-C6H2-3,4-F2), obtained via rearrangement of the aromatic C-H bonds, which demonstrates that Ni(PEt3)2 is kinetically capable of C-H bond activation, even in the presence of C-F bonds. The intermediate [(PEt3)2Ni]2(mu-eta2:eta2-C6H2-4,5-F2) was isolated and crystallographically characterized; the mu-eta2:eta2-bonding mode observed is unprecedented in aryne chemistry. 相似文献
49.
Cao S Bennett TD Keen DA Goodwin AL Cheetham AK 《Chemical communications (Cambridge, England)》2012,48(63):7805-7807
We report the rapid amorphization of the prototypical substituted zeolitic imidazolate framework, ZIF-8, by ball-milling. The resultant amorphous ZIF-8 (a(m)ZIF-8) possesses a continuous random network (CRN) topology with a higher density and a lower porosity than its crystalline counterpart. A decrease in thermal stability upon amorphization is also evident. 相似文献
50.
Lawrie G Grøndahl L Battersby B Keen I Lorentzen M Surawski P Trau M 《Langmuir : the ACS journal of surfaces and colloids》2006,22(1):497-505
The ability to control the surface properties and subsequent colloidal stability of dispersed particles has widespread applicability in many fields. Sub-micrometer fluorescent silica particles (reporters) can be used to actively encode the combinatorial synthesis of peptide libraries through interparticle association. To achieve these associations, the surface chemistry of the small fluorescent silica reporters is tailored to encourage robust adhesion to large silica microparticles onto which the peptides are synthesized. The interparticle association must withstand a harsh solvent environment, multiple synthetic and washing procedures, and biological screening buffers. The encoded support beads were exposed to different solvents used for peptide synthesis, and different solutions used for biological screening including phosphate buffered saline (PBS), 2-[N-morpholino]ethane sulfonic acid (MES) and a mixture of MES and N-(3-dimethyl-aminopropyl)-N'-ethylcarbodiimide (EDC). The number of reporters remaining adhered to the support bead was quantified after each step. The nature of the associations were explored and tested to optimize the efficiency of these phenomena. Results presented illustrate the influence of the surface functionality and polyelectrolyte modification of the reporters. These parameters were investigated through zeta potential and X-ray photoelectron spectroscopy. 相似文献