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1.
We have recently reported on dodecamer peptides (HPPMDFHKAMTR, CHPQPLKSRNPL) which recognize 52-58th and 197-203rd amino acid sequences of glucose oxidase (GOx) by screening via a phage random peptide library. In this study, a side-chain protected peptide monomer (PPM) was synthesized using two peptides (HPPMDFHKAMTR, SHPQPLKSRNPL) and acryloyl chloride. The peptide-conjugated polymer (PCP) was copolymerized with PPMs and N,N-diethylacrylamide (DEAA). The affinity of PCPs to GOx was estimated using surface plasmon resonance detection. This study suggests that PCP is a valuable molecular recognition biomolecule. 相似文献
2.
The quasiclassical trajectory calculation of the I + HI collision is performed in order to study the exchange and endothermic reaction channels. The rate constant of the exchange reaction I′ + HI → HI′ + I is found to be equal to 7.7 × 1011 cm3/mol s at room temperature of 300 K. The study of the endothermic reaction I + HI → H + I2 shows that it takes place only in configurations with large bend angles. Due to the non-collinear character of this reaction its threshold (2 eV) exceeds significantly the threshold of the minimal energy (collinear) reaction path (1.55 eV). 相似文献
3.
Maki Onoda Takefumi Uchiyama Ken-Ichi Mawatari Kiyoko Kaneko Kazuya Nakagomi 《Analytical sciences》2006,22(6):815-817
A simple batch method for the fluorometric determination of hydrogen peroxide using phosphine-based fluorescent reagents has been developed. A rapid, mild and selective derivatization reaction was achieved by adding sodium tungstate dihydrate to the reaction mixture of hydrogen peroxide and a phosphine-based fluorescent reagent. When 4-diphenylphosphino-7-methylthio-2,1,3-benzoxadiazole was used as a reagent, the derivatization reaction was completed after 2 min at room temperature. The calibration curve was linear between 12.5 and 500 ng hydrogen peroxide in a 10 microL sample solution. This method is accurate and has potential for on-line applications. 相似文献
4.
Bond IA Budding E Conway MJ Fenton KB Fujii H Fujii Z Fujimoto M Hasegawa H Hayashida N Honda M Hotta N Humble JE Kabe S Kasahara K Kifune T Masaike A Matsubara Y Mitsui K Miura Y Mori M Murakami K Muraki Y Nagano M Nakamura K Nakamura T Norris PM Ohashi Y Okada A Saito T Sakata M Sato H Shibata S Shima M Storey JR Tanimori T Teshima M Torii S Uchino K Watase Y Woodhams MD Yamamoto Y Yock PC Yuda T 《Physical review letters》1988,61(20):2292-2295
5.
Satoshi Ito Kazuya Koizumi Katsuhiko Fukuda Naohiro Kameta Tsukasa Ikeda Toru Oba Kazuhisa Hiratani 《Tetrahedron letters》2006,47(48):8563-8566
A new series of BINOL-based macrocycles with two phenolic protons have been synthesized via oxidative coupling reaction using CuCl(OH)-TMEDA. 相似文献
6.
(Styrene-p-chlorostyrene) triblock copolymers of the ABA and BAB types (A—polystyrene; B—poly-p-chlorostyrene) were prepared by anionic polymerization and their conformational behaviours in solutions were studied from measurements of the dipole moments. Two solvents, toluene and cumene, were used for the study; toluene is a good solvent for both polystyrene and poly-p-chlorostyrene whereas cumene is a selective solvent, good for polystyrene but poor for poly-p-chlorostyrene. It was found that the dipole moments of the block copolymers measured in toluene are the same for the ABA and BAB copolymers; in cumene however the dipole moment of the BAB copolymer is smaller than that of the ABA copolymer. The results give an additional support to our previous conclusion that the conformation of the block copolymers in a good solvent such as toluene could be approximated with a pseudo-random coil form; in a selective solvent, however, some anomalies take place in the conformation of the block copolymers, as deduced from intrinsic viscosity, osmotic pressure and light scattering measurements. 相似文献
7.
Seiji Miyano Osamu Yamashita Kunihiro Sumoto Keiyu Shima Mariko Hayashimatsu Fumio Satoh 《Journal of heterocyclic chemistry》1987,24(1):271-274
The method for preparing 7a-substituted hexahydro-1H-pyrrolizines 2 from 1,2,3,5,6,7-hexahydropyrrol-izinium Perchlorate (3) was investigated, by which introduction of a wide variety of functionalities on C(7a) could be achieved easily. 相似文献
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10.
Yuichiro Hori Miyako Nishiura Tomomi Tao Reisuke Baba Steven D. Bull Kazuya Kikuchi 《Chemical science》2021,12(7):2498
Reversible enzymatic post-translational modification of the ε-amino groups of lysine residues (e.g. N-acylation reactions) plays an important role in regulating the cellular activities of numerous proteins. This study describes how enzyme catalyzed N-deprotection of lysine residues of non-fluorescent peptide-coumarin probes can be used to generate N-deprotected peptides that undergo spontaneous O- to N-ester transfer reactions (uncatalyzed) to generate a highly fluorescent N-carbamoyl peptide. This enables detection of enzyme catalyzed N-deacetylation, N-demalonylation, N-desuccinylation and N-demethylation reactions activities towards the N-modified lysine residues of these probes using simple ‘turn on’ fluorescent assays.We developed “turn-on” fluorescent probes that detect enzymatic lysine deacylation and demethylation critical for epigenetic and other cellular phenomena, using intramolecular O- to N-ester transfer reactions. 相似文献