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991.
Young Hoon LeeAsuka Ohta Yuki YamamotoYasuka Komatsu Kazuya KatoTetsuya Shimizu Hideaki ShinodaShinya Hayami 《Polyhedron》2011,30(18):3001-3005
The bzimpy iron(II) complexes, 1-3, containing branched long alkyl chains were synthesized and characterized in detail. The temperature-dependant magnetic susceptibility of 1 showed gradual spin crossover behavior from low spin to high spin state, while 2 retained only low spin state in the same condition. Interestingly, 3 displayed an abrupt spin transition in temperature range from T1/2↑ = 236 K to T1/2↓ = 230 K with the thermal hysteresis loop about 6 K. The differential scanning calorimetric analysis of 3 revealed two species of liquid crystal phase transitions at 236 K and 351 K, respectively. 相似文献
992.
Wada K Ogiwara A Nagasaka K Tanaka N Komatsu Y 《Rapid communications in mass spectrometry : RCM》2011,25(7):960-968
We developed a novel software named i-RUBY (identification-Related qUantification-Based strategY algorithm for liquid chromatography/tandem mass spectrometry (LC/MS/MS) data) that enables us to perform fully automatic ion current-based spectral feature analysis of highly accurate data obtained by LC/MS/MS. At the 1st step, this software utilizes accurate peptide/protein identification information for peak detection and peak matching among measurements. Then, at the 2nd step, it picks yet unidentified peaks and matches them to the peaks identified at the 1st step by a linear interpolation algorithm. The analysis of human plasma externally spiked with a known amount of yeast alcohol dehydrogenase 1 showed a good linear relationship between the amount of protein spiked and the quantitative values obtained by i-RUBY analysis. Experiment using human plasma digests spiked with a mixture of known amounts of synthetic peptides derived from two yeast proteins, alcohol dehydrogenase 1 and glucose-6-phospate isomerase, showed the expansion by the 2nd step of i-RUBY of the lower quantification limits to 1/10 to 1/1000 of those reached only by identified peaks at the 1st step. Good correlations between the i-RUBY results and the amount of proteins were confirmed by the analysis of real samples, i.e., sera of normal subjects and cancer patients, by comparing quantitative values of acute-phase proteins obtained by i-RUBY analysis of LC/MS/MS data with those obtained by an immunological method using Bio-Plex. These results taken together show that i-RUBY is a useful tool for obtaining dependable quantitative information from highly accurate shotgun-proteomics LC/MS/MS data. 相似文献
993.
994.
If the supersymmetry (SUSY) is a solution to the hierarchy problem, it is puzzling that any SUSY particle has not been discovered yet. We show that there is a low-scale conformal gauge mediation model which contains all necessary ingredients, i.e. not only a SUSY-breaking dynamics and a gauge mediation mechanism, but also a candidate for the dark matter. The model has only one free mass parameter, that is, the mass for messengers. In this model, the dark matter is provided by a composite particle in the SUSY-breaking sector, and the observed value of the dark matter density uniquely fixes the mass of messengers at the order of 102 TeV. Then, the sfermion and gaugino masses are fixed to be of order 102–103 GeV without any arbitrariness, thus the SUSY particles are expected not to be discovered at the Tevatron or LEP, while having a discovery possibility at the LHC. 相似文献
995.
Dr. Masafumi Minoshima Taro Umeno Kohei Kadooka Margaux Roux Namiko Yamada Prof. Dr. Kazuya Kikuchi 《Angewandte Chemie (International ed. in English)》2023,62(18):e202301704
To understand the function of protein in live cells, real-time monitoring of protein dynamics and sensing of their surrounding environment are important methods. Fluorescent labeling tools are thus needed that possess fast labeling kinetics, high efficiency, and long-term stability. We developed a versatile chemical protein-labeling tool based on fluorophore-conjugated diazabicyclooctane β-lactamase inhibitors (BLIs) and wild-type TEM-1 β-lactamase protein tag. The fluorescent probes efficiently formed a stable carbamoylated complex with β-lactamase, and the labeled proteins were visualized over a long period of time in live cells. Moreover, use of an α-fluorinated carboxylate ester-based BLI prodrug enabled the probe to permeate cell membranes and stably label intracellular proteins after unexpected spontaneous ester hydrolysis. Lastly, combining the labeling tool with a pH-activatable fluorescent probe allowed visual monitoring of lysosomal protein translocation during autophagy. 相似文献
996.
Kang Xia Prof. Dr. Kazuya Yamaguchi Prof. Dr. Kosuke Suzuki 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2023,135(1):e202214506
Polyoxometalates (POMs), anionic metal-oxygen nanoclusters that possess various composition-dependent properties, are widely used to modify the existing properties of metal nanoparticles and to endow them with new ones. Herein, we present an overview of recent advances in hybrid materials that consist of metal nanoparticles and POMs. Following a brief introduction on the inception of this area and its development, representative properties and applications of these materials in various fields such as electrochemistry, photochemistry, and catalysis are introduced. We discuss how the combination of two classic inorganic materials facilitates cooperative and synergistic behavior, and we also give personal perspectives on the future development of this field. 相似文献
997.
William J. Bailey Paul Y. Chen Shuh-Cheng Chen Wen-Bin Chiao Takeshi Endo Benjamin Gapud Vijaya Kuruganti Yin-Nian Lin Zhende Ni Cai-Yuan Pan Scott E. Shaffer Luann Sidney Shang-Ren Wu Noboru Yamamoto Noboro Yamazaki Kazuya Yonezawa Lin-Lin Zhou 《Macromolecular Symposia》1986,6(1):81-100
Since a carbon-oxygen double bond is considerably more stable than a carbon-carbon double bond, it has been possible to use this driving force to promote free radical ring-opening polymerization of unsaturated heterocyclic compounds. This process, for the first time, has permitted the introduction of functional groups, such as esters, amides and carbonates, into the backbone of addition polymers. Hydrolysis of the copolymers with common monomers produced oligomers capped with hydroxyl, amino or carboxylic acid groups. The presence of an ester group in a copolymer, such as in a copolymer of ethylene, render the copolymer biodegradable. 相似文献
998.
Junjie Wang Prof. Dr. Tianping Ying Dr. Jun Deng Dr. Cuiying Pei Dr. Tongxu Yu Dr. Xu Chen Yimin Wan Mingzhang Yang Dr. Weiyi Dai Dr. Dongliang Yang Prof. Dr. Yanchun Li Prof. Dr. Shiyan Li Prof. Dr. Soshi Iimura Prof. Dr. Shixuan Du Prof. Dr. Hideo Hosono Prof. Dr. Yanpeng Qi Prof. Dr. Jian-gang Guo 《Angewandte Chemie (International ed. in English)》2023,62(10):e202216086
Searching for functional square lattices in layered superconductor systems offers an explicit clue to modify the electron behavior and find exotic properties. The trigonal SnAs3 structural units in SnAs-based systems are relatively conformable to distortion, which provides the possibility to achieve structurally topological transformation and higher superconducting transition temperatures. In the present work, the functional As square lattice was realized and activated in Li0.6Sn2As2 and NaSnAs through a topotactic structural transformation of trigonal SnAs3 to square SnAs4 under pressure, resulting in a record-high Tc among all synthesized SnAs-based compounds. Meanwhile, the conductive channel transfers from the out-of-plane pz orbital to the in-plane px+py orbitals, facilitating electron hopping within the square 2D lattice and boosting the superconductivity. The reorientation of p-orbital following a directed local structure transformation provides an effective strategy to modify layered superconducting systems. 相似文献
999.
Dr. Yoshiyuki Manabe Yuki Iizuka Ryuku Yamamoto Keita Ito Kanae Hatano Dr. Kazuya Kabayama Prof. Koichi Fukase 《Angewandte Chemie (International ed. in English)》2023,62(30):e202304779
Antibody dynamics on membranes, such as endocytosis and clustering, are vital in determining antibody functions. In this study, we demonstrated that glycan conjugation can modulate antibody dynamics through the glycan–lectin interaction to regulate its potency. The anti-HER2 antibody, an anti-breast-cancer antibody, was conjugated with galactose-containing N-glycan, and its internalization was suppressed by interaction with galectin-3, leading to enhanced complement-dependent cytotoxic (CDC) activity. This glycan–antibody conjugate is proposed as a new approach to modulate antibody activity and may provide an alternative strategy for redeveloping antibody drugs that do not exhibit sufficient activity. 相似文献
1000.
Kazuya Haraguchi Shinobu Sato Manabu Habu Naomi Yada Mana Hayakawa Masaaki Sasaguri Izumi Yoshioka Kazuhiro Tominaga Shigeori Takenaka 《Electroanalysis》2023,35(8):e202200564
In order to improve the survival rate of oral squamous cell carcinoma (OSCC) patients, a reliable diagnostic method for early OSCC detection is required that is minimally invasive, less burdensome to the patient, and has high sensitivity and specificity. Therefore, we performed the detection of abnormal methylation at three locations in the hTERT promoter region of oral exfoliated cells by employing the ferrocenylnaphthalene diimide (FND)-based electrochemical hybridization assay (FND-EHA) using three types of DNA probe-immobilized electrodes. We also performed liquid cytology using oral exfoliated cells and compared these obtained data to evaluate whether FND- EHA can be used as an OSCC screening system. The results showed a good correlation between this method and conventional OSCC screening, and cytology. In addition, FND-EHA was also able to determine samples that had been ambiguously determined by liquid cytology. This indicates that FND-EHA may be useful as an OSCC screening system. 相似文献