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91.
Kazunori Kurosawa Masahiko Suenaga Takahiko Inazu Tamotsu Yoshino 《Tetrahedron letters》1982,23(50):5335-5338
The title compounds, I, were synthesized by the dialkylation of TosMIC, II, with appropriate bis (halomethyl) compounds, III, under phase-transfer condition, followed by acid hydrolysis. 相似文献
92.
Host 1 based on the phenolphthalein skeleton and two crown ether moieties demonstrated opposite behaviors toward sodium and potassium cations caused by bidirectional complexation. [reaction: see text] 相似文献
93.
94.
Yasuyo Maezawa Yoichiroh Hosokawa Kazunori Okano Mie Matsubara Hiroshi Masuhara 《Applied Physics A: Materials Science & Processing》2010,101(1):127-131
When a stress wave generated by focusing a femtosecond laser is loaded on an animal cell adhered on a substrate, the cell
is detached from the substrate. There are two possible mechanisms for the cell detachment: (a) The cell is detached from a
scaffold coated on a glass plate, and (b) the cell is detached from the glass plate with the scaffold. In this work, we have
studied the cell-detachment mechanism by visualizing the scaffold with a fluorescence probe of quantum dots. When the cell
was detached from the substrate, fluorescence from the scaffold simultaneously disappeared from the glass plate, although
the scaffold was not irradiated by the laser. This indicates that detachment due to the stress wave is attributed to mechanism (a).
On the other hand, when the cell was detached from the substrate by a trypsin treatment, the fluorescence from the scaffold
remained, suggesting mechanism (b). By comparing both results, it is considered that physiological damage of the cell membrane
during the detachment process by femtosecond laser-induced stress wave is less than that due to the trypsin treatment. 相似文献
95.
In this article, we study the diagonal F-threshold, that is, the F-threshold of the maximal ideal with respect to the maximal ideal itself. In particular, we give a formula of the diagonal F-thresholds for binomial hypersurfaces, and compare the diagonal F-thresholds with F-pure thresholds for strongly F-regular binomial hypersurfaces. As a result, we prove that those diagonal F-thresholds always exist and they are rational numbers in that case. 相似文献
96.
We present an analytic study of the physics of the glasma which is a strong classical gluon field created at early stage of high-energy heavy-ion collisions. Our analysis is based on the picture that the glasma just after the collision is made of color electric and magnetic flux tubes extending in the longitudinal direction with their diameters of the order of 1/Qs (Qs is the saturation scale of the colliding nuclei). We find that both the electric and magnetic flux tubes expand outwards and the field strength inside the flux tube decays rapidly in time. Next we investigate whether there exist instabilities against small rapidity-dependent perturbations for a fixed color configuration. We find that the magnetic background field exhibits an instability induced by the fluctuations in the lowest Landau level, and it grows exponentially in the time scale of 1/Qs. For the electric background field we find no apparent instability while the possible relation to the Schwinger mechanism for particle pair creations is suggested. 相似文献
97.
98.
Yulu Jiang Dr. Taro Ozaki Mei Harada Tadachika Miyasaka Dr. Hajime Sato Dr. Kazunori Miyamoto Dr. Junichiro Kanazawa Dr. Chengwei Liu Prof. Dr. Jun-ichi Maruyama Dr. Masaatsu Adachi Dr. Atsuo Nakazaki Prof. Dr. Toshio Nishikawa Prof. Dr. Masanobu Uchiyama Dr. Atsushi Minami Prof. Dr. Hideaki Oikawa 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2020,132(41):18152-18158
Lolitrems are tremorgenic indole diterpenes that exhibit a unique 5/6 bicyclic system of the indole moiety. Although genetic analysis has indicated that the prenyltransferase LtmE and the cytochrome P450 LtmJ are involved in the construction of this unique structure, the detailed mechanism remains to be elucidated. Herein, we report the reconstitution of the biosynthetic pathway for lolitrems employing a recently established genome-editing technique for the expression host Aspergillus oryzae. Heterologous expression and bioconversion of the various intermediates revealed that LtmJ catalyzes multistep oxidation to furnish the lolitrem core. We also isolated the key reaction intermediate with an epoxyalcohol moiety. This observation allowed us to establish the mechanism of radical-induced cyclization, which was firmly supported by density functional theory calculations and a model experiment with a synthetic analogue. 相似文献
99.
Daisuke Asai Tadashi Fukuda Kazunori Morokuma Daiki Funamoto Yuko Yamaguchi Takeshi Mori Yoshiki Katayama Keigo Shibayama Hideki Nakashima 《Macromolecular bioscience》2019,19(10)
Vaccines typically contain an antigen, delivery system (vehicle), and adjuvant, all of which contribute to inducing a potent immune response. Consequently, design of new vaccines is difficult, because the contributions and interactions of these components are difficult to distinguish. Here, it is aimed to develop an easy‐to‐use, non‐immunogenic, injectable depot system for sustained antigen release that will be suitable for assessing the efficacy of prolonged antigen exposure per se for inducing an immune response. This should mimic real‐life infections. Recombinant elastin‐like polypeptides with periodic cysteine residues (cELPs) are selected, which reportedly show little or no immunogenicity, as carriers and tetanus toxoid (Ttd) as an antigen. After subcutaneous injection of the mixture, cELP rapidly forms a disulfide cross‐linked hydrogel in situ, within which Ttd is physically incorporated, affording a biodegradable antigen depot. A series of Ttd‐containing hydrogels is examined. A single injection induces high levels of tetanus antibody with high avidity for at least 20 weeks in mice. The chain length of cELP proves critical, whereas differences in hydrophobicity has little effect, although hydrophilic cELPs are more rapidly biodegraded. This system's ability to distinguish the contribution of sustained antigen release to antibody induction should be helpful for rational design of next‐generation vaccines. 相似文献
100.
Dr. Masashi Hasegawa Chika Hasegawa Yuki Nagaya Prof. Dr. Kazunori Tsubaki Prof. Dr. Yasuhiro Mazaki 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(59):e202202218
Chiral macrocyclic dimers, trimers, and tetramers composed of paraphenylene and tethered binaphthyl were synthesized, and their molecular structures and chiroptical properties were investigated. X-ray analysis and theoretical calculations revealed that multiple twisted molecular structures – dimers, trimers, and tetramers – adopt figure-of-eight, Möbius triangle, and concave rectangle structures, respectively. These homologues have large ϵ values in their UV-vis absorption spectra because of the π-conjugation of the naphthalene-phenylene-naphthalene frameworks. Owing to the shape-persistent ring structure and tethering with −OCH2CH2O−, high fluorescence quantum yields and a relatively high dissymmetry factor gCPL in circularly polarized luminescence (CPL) spectra were achieved. This results in CPL brightness (BCPL) of over 100, which is greater than that of the conventional organic CPL dye. 相似文献