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991.
S Atsuumi M Nakano Y Koike S Tanaka K Matsuyama M Nakano H Morishima 《Chemical & pharmaceutical bulletin》1992,40(2):364-370
The synthesis and structure-activity relationships of transition-state renin inhibitors containing the homostatine analogues at the scissile bond are described. These inhibitors incorporate the amino acid side chains corresponding to positions 7-12 (P4-P2') of angiotensinogen. Ethyl, 2-hydroxyethyl and 3-hydroxypropyl groups at position 2 of the homostatine analogues (P1') are more effective for increasing potency than the isopropyl group. A combination of residues at P1, P3 and P4 is important for potency and this result suggests that S1, S3 and S4 form a huge hydrophobic core together in renin. 相似文献
992.
993.
Kazuhiko Hashimoto Hiroshi Sumitomo 《Journal of polymer science. Part A, Polymer chemistry》1971,9(1):107-114
Anionic copolymerization of β-cyanopropionaldehyde (M1) with methyl isocyanate (MeI, M2) was studied with use of benzophenone–dilithium complex as initiator at ?78°C. The values of monomer reactivity ratio were determined to be r1 = 8.3 ± 0.3 and r2 = 0.01 ± 0.01. The structure of resulting copolymer was investigated by means of NMR analysis. The MeI unit is presumed to enter the copolymer chain through its C?N opening. 相似文献
994.
To provide insight into the polycyclization mechanism of squalene by squalene-hopene cyclase (SHC) from Alicyclobacilus acidocaldarius, some analogs of nor- and bisnorsqualenes were synthesized including the deuterium-labeled squalenes and incubated with the wild-type SHC, leading to the following inferences. (1) The deprotonation reaction for the introduction of the double bond of the hopene skeleton occurs exclusively from the Z-methyl group on the terminal double bond of squalene. (2) 3R-Oxidosqualene was folded in a boat conformation for the A-ring construction, while the 3S-form was in a chair structure. (3) The terminal two methyl groups are indispensable both for the formation of the 5-membered E-ring of the hopene skeleton and for the initiation of the polycyclization cascade, but the terminal Z-methyl group has a more crucial role for the construction of the 5-membered E-ring than the E-methyl group. (4) Some of the novel terpene skeletons, 36, 37, 39 and 40, were created from the analogs employed in this investigation. 相似文献
995.
Uyama H Kuwabara M Tsujimoto T Nakano M Usuki A Kobayashi S 《Macromolecular bioscience》2004,4(3):354-360
This study deals with the preparation and properties of a new class of organic-inorganic hybrids from renewable resources. The hybrids were synthesized by an acid-catalyzed curing of epoxidized triglycerides in the presence of an organophilic montmorillonite (a modified clay). The mechanical properties were improved by the incorporation of clay in the oil-based polymer matrix. The reinforcement effect due to the addition of clay was confirmed by dynamic viscoelasticity analysis. The hybrids showed relatively high thermal stability. The co-curing of epoxidized soybean and linseed oils in the presence of clay produced hybrids with controlled mechanical and coating properties. The barrier property of the hybrid towards water vapor was superior to that of the oil polymer. The development of the present hybrids consisting of inexpensive renewable resources, triglyceride and clay is expected to contribute to global sustainability. 相似文献
996.
We have developed a flame‐retardant polycarbonate resin whose flame retardancy is greatly enhanced by adding fly ash (a by‐product from thermal power plants). Fly ash with comparatively small average particle sizes (<10 µm) raised the flame retardancy of polycarbonate because of the hydrogen bond that forms between the polycarbonate and the hydroxy group on the fly ash surface. This bond primarily improves the heat resistance of the polycarbonate and also isomerizes the polycarbonate to promote carbonization. The polycarbonate with 25 wt% of the fly ash showed good other main characteristics, such as mechanical properties and moldability, comparable to those of a flame retardant polycarbonate reinforced with glass fiber, used for electronic products such as desktop computers, etc. Applying the fly ash eliminates the need to use current retardants such as organic halogen compounds and thus promotes the perceived environmental safety of flame‐ retardant polycarbonate. In addition, being able to use less raw resin by adding the fly ash means that less energy is required to manufacture flame‐retardant polycarbonate. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
997.
The charge-transfer interaction of pyridinium salts with lysozyme and L-tryptophan has been investigated by visible absorption, circular dichroism and fluorescence spectroscopy. Four quaternized and substituted pyridinium salts were used as electron acceptors. L-tryptophan was used as a model compound of electron donor for the purpose of the comparison with lysozyme. The binding constants obtained from absorption and circular dichroism spectra were 2.0–13 M–1 and the sequence of the magnitude was found as EPCl(1-ethylpyridinium chloride) < MPCl(1-methylpyridinium chloride) < MNCl(1-methylnicotinamide chloride) < MNMCl(1-methyl-3-carbomethoxypyridinium chloride), which could be explained by the electron affinity of the pyridinium salt. The fluorescence spectra of lysozyme and L-tryptophan in the absence and presence of pyridinium salts were interpreted by Stern-Volmer plot. The static constants thus determined were in agreement with the binding constants obtained by other methods. 相似文献
998.
Kazushi Sorakubo Takeshi Yanai Kenichi Nakayama Muneaki Kamiya Haruyuki Nakano Kimihiko Hirao 《Theoretical chemistry accounts》2003,110(5):328-337
A density functional theory method using partially fixed molecular orbitals (PFMOs) is presented. The PFMOs, which have some fixed molecular orbital coefficients and are non-orthogonal, are a generalization of the extreme localized orbitals (ELMOs) of Couty, Bayse, and Hall (1997) Theor Chem Acc 97:96. A non-orthogonal Kohn-Sham method with these PFMOs is derived, and is applied to molecular calculations on the ionization potential of pyridine, the energy difference between cis- and trans-butadiene, the reaction barrier height of the cyclobutene-cis-butadiene interconversion, and the potential energy curve of the hydrogen shift reaction of hydroxycarbene to formaldehyde. The PFMO Kohn-Sham method reproduces well the results of the full Kohn-Sham method without having a restriction on the molecular orbital coefficients. The difference is less than 0.1 eV in the ionization potential and about 0.1 kcal/mol in the barrier height and in the potential energy calculations. 相似文献
999.
Takashi Okazoe Jun-ichi Hibino Kazuhiko Takai Hitosi Nozakil 《Tetrahedron letters》1985,26(45):5581-5584
The combination of CH2I2-ZN-Ti(OiPr)4 or CH2I2-ZN-Me3Al is effective for the selective methylenation of aldehydes. Seletive methylenation of a ketone group is performed by pretreatment of a substrate with Ti(NET2)4. 相似文献
1000.
Shin-ichi Fukuzawa Yoshitaka KomuroNarihito Nakano Shinya Obara 《Tetrahedron letters》2003,44(18):3671-3674
Several bisimine and diol-based chiral ligands were examined as scandium(III) triflate complexes in the asymmetric Diels-Alder reaction of cyclopentadiene (2) with 3-acryloyloxazolidin-2-one (1) in the presence of 2,6-lutidine: the scandium/salen complex was revealed to be the most effective catalyst, which afforded the endo adduct in a good yield with 85% ee. Addition of a tertiary amine, such as 2,6-lutidine, was critical to achieve high enantioselectivity; enantioselectivity was remarkably decreased in the absence of the amine. 相似文献